抗菌材料由於其不使細菌產生抗藥性等諸多優異特性，在當今抗菌領域佔有越來越大的比重。奈米纖維素作為地球上最豐富的生物聚合物，具有生物相容性和無毒性等特點。由於奈米纖維素表面有大量的羥基，很容易與不同的分子結合，產生不同的性質。甲基丙烯酸叔丁基氨基乙酯聚合物（poly[2-(tert-butylamino)ethyl methacrylate]，PTBAEMA）是優良的抗菌劑，生物毒性很低；赤蘚紅（Erythrosine）是優良的光敏劑，由其觸發的光動力殺菌具有高效的特點，更重要的是這兩者的殺菌機制都不會使細菌產生抗藥性，因此適合與奈米纖維素結合並應用於抗菌領域。本研究對奈米纖維素進行了改性，並接枝上PTBAEMA和赤蘚紅，得到具有抗菌能力的奈米纖維素複合材料，並測試了其抗菌性能，在綠光照射30分鐘或白光照射60分鐘後，可以對大腸桿菌和金黃色葡萄球菌做到完全殺菌，且製成後對這兩菌種光動力殺菌有效時間至少為三周。然後將其與矽膠複合，通過3D列印列印出半月板植入物，測試機械性質後可以符合人體半月板的抗拉強度，對於金黃色葡萄球菌與大腸桿菌也保持著優異的殺菌能力同時有著優秀的生物相容性。

This experiment was conducted to develop an antimicrobial material with dual bactericidal properties and to explore the feasibility of applying it to human meniscus implants. Using cellulose nanocrystals (CNC) as a carrier for the antimicrobial moiety, the CNC was chemically modified and grafted with the antimicrobial polymer poly[2-(tert-butylamino)ethyl methacrylate] (PTBAEMA) and the photosensitiser erythrosine to obtain the Ery-DACNC-g-PTBAEMA antimicrobial material. The antimicrobial performance of the material was tested. It was found to be completely bactericidal against Escherichia coli and staphylococcus aureus after 30 minutes of green light irradiation or 60 minutes of white light irradiation, and was also consistently bactericidal in the absence of light. The meniscus implant produced by mixing it with silicone and using 3D printing technology conforms to the mechanical strength of a human meniscus implant, while maintaining excellent bactericidal properties, a long effective bactericidal lifespan and good biocompatibility.

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