當體內含有過量鐵離子，會增加生物體內自由基的產生，造成氧化性壓力，進而引起肝臟及腎臟衰竭。許多研究指出，芝麻油具有高度的穩定性及抗氧化能力，能減輕氧化性傷害，並能減緩器官衰竭。芝麻酚是芝麻油的主要木質素成份之一，具有強抗氧化能力，可能在芝麻油的抗氧化功效中扮演重要角色。本研究之目的在探討抗氧化劑芝麻油及芝麻酚，對急性鐵中毒所引發之氧化性壓力以及肝腎功能異常的影響。實驗小鼠以腹腔注射給予胺三醋酸鐵（Fe-NTA; 2 mg/kg）誘導急性鐵中毒，且以皮下注射給予芝麻油（4 ml/kg）或芝麻酚（30 mg/kg），並於3小時後進行肝腎切片及採集血液樣本，測定血中超氧化陰離子、血清中二價鐵離子濃度、血中一氧化氮含量、羥自由基、脂質過氧化反應、肝腎功能指標及觀察肝腎切片。結果顯示，給予芝麻油或芝麻酚都能有效降低Fe-NTA所引起之超氧化陰離子、二價鐵離子濃度、羥自由基、脂質過氧化反應，改善肝腎功能異常，並減輕肝腎傷害。再者，於Fe-NTA引發急性鐵中毒三十分鐘後，再給予芝麻油或芝麻酚，也都能有效降低肝腎功能異常。總之，抗氧化物芝麻油和芝麻酚，可能透過減少自由基的生成，改善急性鐵中毒所引起之氧化性壓力及肝腎傷害；甚至急性鐵中毒發生後再給予芝麻油或芝麻酚，也具有降低肝腎傷害的功用。

　Iron overload causes oxidative stress resulted in organ injury. Sesame oil and its lignan sesamol are potent antioxidants, both of which can reduce reactive oxygen species and lipid preoxidation; and attenuate multiple organ failure during oxidative stress. The aim of this study was to investigate the effects of sesame oil and sesamol on iron-induced oxidative stress and multiple organ injury in mice. Mice were given sesame oil (4 ml/kg, s.c.) or sesamol (30 mg/kg, s.c.) just after ferric-nitrilotriacetate (Fe-NTA) (2 mg/kg, i.p.) and parameters were determined 3 hours after Fe-NTA administration. Superoxide anion, serum Fe2+ concentration, serum nitric oxide production, blood hydroxyl radical, and lipid peroxidation were examined. He¬patic and renal functions were assessed by biochemical and histological examinations. Sesame oil or sesamol significantly reduced superoxide anion, Fe2+ concentration, hydroxyl radical, and lipid peroxidation; and attenuated hepatic and renal injuries in Fe-NTA-treated mice. Sesame oil and sesamol ameliorated hepatic and renal function after the onset of iron poisoning. In summary, sesame oil and sesamol attenuated hepatic and renal injuries preventively and therapeutically, which may result from the amelioration of oxidative stress in acute iron poisoning in mice.

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