人工關節置換手術已經逐漸增加被用來減緩疼痛及改善人體關節的機動性，並增進其生活品質。雖然人工關節置換術通常可以解除痛苦，而且可以恢復關節的部份功能， 仍然被視為最後的方法。在藥物，關節注射，休息或其他手術都失敗後才會進行人工關節置換手術。其中也必須注意人工關節感染的問題。
在台灣已經發現人工關節的感染率很高。因為手術並沒有在一個標準的人類排氣系統下完成。於是對全台灣人工關節感染做全面的調查，結果發現台灣的感染率遠高於美國，因此發展有效且便宜的預防人工關節感染對台灣有急迫性的須要。
預防人工關節感染的方法有環繞操作抗菌預防法和一個層流外科手術環境的使用，而手術伴隨引起的感染會導致發病及不健全，進而需要更多的醫療費用。
本研究利用不同比例及濃度的可生物裂解polylactide-co-polyglycolide(PLGA)共高分子材料塗布於含抗生素的不同人工關節表面上，測試抗生素釋放情形。
在有抗生素藥物的結晶面金屬片上包覆PLGA(85:15)釋放並抑制菌種可以達到3天以上;而包覆PLGA(50:50)可以達到5天以上。另外在有抗生素藥物的噴砂面金屬片上包覆15% PLGA(85:15)與5%及15% PLGA(50:50)藥物釋放時間都可以達到7天以上。
一般金屬片浸泡抗生素釋放時間卻最多只能達到兩小時，而有包覆PLGA的金屬片很明顯可以延長控制抗生素釋放的時間。

Prosthetic-joint replacement is used increasingly to alleviate pain and to improve mobility for damaged joints. Infections associated with prosthetic joints cause significant morbidity and account for a substantial proportion of health care expenditures. It is not surprising to find a lot of infected artificial joints in our country because none of the surgeries were done in a standard Humane Exhaust System. Rate of deep infection after artificial joint implantation in Taiwan was higher than US.
Biodegradable polymers in several forms offer promising results for drug delivery or release in several prospects. Biodegradable polylactide-co-polyglycolide (PLGA) polymer of different concentration and copolymeric ratio encapsulate the antibiotics loaded artificial stem surface will be tested for its long term and controllable drug release anti-infective effect.
PLGA (85:15) encapsulating the antibiotics loaded Co-Cr-Mo bead disc, the antibiotics can be released and inhibit more than 3 days. PLGA (50:50) encapsulating the antibiotics loaded Co-Cr-Mo bead disc,the antibiotics can be released more than 5 days. However, PLGA (85:15 or 50:50) encapsulating the antibiotics loaded Sand blasting disc can release more than 7 days. However, the antibiotics loaded metals can release within 2 hour, PLGA coating can prolong the time of Antibiotics release.

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