心血管疾病若嚴重到無法用藥物控制，需要進行血管繞道手術或放入血管支架，在血管阻塞的部位進行血管的擴張。目前市售血管支架主要有三種，一般金屬支架、塗藥金屬支架、全吸收式生物血管支架，各有其優缺點。本論文期望以飛秒光纖雷射誘發週期表面微結構技術，在316L不鏽鋼金屬表面製作微結構，目標為親水結構達到血清接觸角<20°，解決市售支架的缺點。
本研究利用田口實驗設計方法設計L18直交表作實驗設計，分別選擇八個控制因子，包含雷射重複頻率(MHz)、雷射功率(W)、Overlapping(mm)、掃描速度(mm/sec)、聚焦高度(mm)、掃描路徑、氮氣(L/min)、抽氣(L/min)，並定義品質特性因子，以望小為理想指標，了解各種實驗設計對接觸角的影響，發現接觸角最小的最佳化參數為氮氣20(L/min) 、雷射功率1.2W、雷射重複頻率1MHz、Overlapping為0.009m、掃描路徑為直線掃描、掃瞄速度1200 mm/sec，此研究結果可以做為未來設計親水性結構的參考。

In the research, it is expected to make microstructures on 316L stainless steel surface by the surface treatment technology of femtosecond laser. The goal is that the resulting hydrophilic structure can reaches the serum contact angle smaller than 20 degrees. The produced structure could help to solve the shortcomings of the commercially available stents.
In the work, the Taguchi method is utilized to design the experimental study with the L18 orthogonal table. Eight control factors are chosen, including laser repetition frequency (MHz), laser power (W), overlapping (mm), scan speed (mm/sec), focus height (mm), scan path, nitrogen flow rate (L/min) and suction flow rate (L/min). The quality characteristic is the contact angle and the smaller-the-better (STB) is selected.

From the experimental data, it can be understood that the influences of the control factors on the contact angle. The optimal combination of the control factors is that the nitrogen flow rate is 20 L/min, the laser power is 1.2 W, the laser repetition frequency is 1 MHz, the overlapping is 0.009 mm, the scanning path is linear scan, the scanning speed is 1200 mm/sec. The resulting contact angle can reach 13.03 degrees. It is expected that the study results can be used as a reference for the future design of hydrophilic structure.

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