隨著癌症罹患人數不斷增加，癌症治療一直是熱門的研究領域。化學動力治療是一應用於癌症治療的方法，透過產生對腫瘤細胞有毒性的活性氧物質以治療癌症，然而化學動力治療仍面臨內源性雙氧水不足的問題，無法提供充足的雙氧水以進行芬頓反應。因此，本研究設計了具有晶格應變 (Lattice strain) 與單原子催化 (Single-atom catalyst) 的FePt@Au/Cu，透過晶格應變與單原子催化促進FePt@Au/Cu產生過氧化氫，以增強化學動力治療效果。
首先合成出FePt@Cu為零價銅，透過加凡尼取代反應合成出FePt@Au/Cu，並於其表面修飾硬脂酸合成出FePt@Au/Cu@SA，以避免材料提早與氧氣反應；透過包吞作用進入目標細胞後，硬脂酸可與細胞膜融合釋放出FePt@Au/Cu，降解釋放銅離子與電子 (Cu → Cu+ + e- → Cu2+ + e-)，氧氣接受電子還原成過氧化氫 (O2 + 2H+ + 2e- → H2O2)，過氧化氫再與銅離子透過類芬頓反應 (Fenton-like reaction) 產生羥基自由基 (Cu+ + H2O2 → Cu2+ + •OH + -OH)。而FePt@Au/Cu之晶格應變、比表面積以及單原子催化，皆進行相關實驗予以佐證上述因素促進了FePt@Au/Cu能產生更多過氧化氫，提升化學動力治療的效果。實驗結果證實，FePt@Au/Cu生成•OH的反應效率最好。DFT計算結果表明，在FePt@Au/Cu上O2兩次被氫化 (O2(a) → OOH, OOH(a) → H2O2) 的活化能 (0.73 eV, 0.65 eV) 均比 Cu (1.02 eV, 0.91 eV)、FePt@Cu (0.97 eV, 0.97 eV) 低，因此FePt@Au/Cu相較於Cu、FePt@Cu具有更快的H2O2生成速率，使FePt@Au/Cu具有更好的化學動力學治療療效。此外，FePt@Au/Cu@SA具有生物可降解特性，可透過尿液代謝方式排出於體外，避免材料累積於生物體內。

Chemodynamic therapy (CDT) is a method used for cancer treatment but limited by insufficient endogenous hydrogen peroxide. Hence, we provide a degradable gold-copper-modified iron-platinum nanocubes (FePt@Au/Cu) with lattice strain and single-atom catalyst, which had excellent cascade oxidase-like and Fenton-like catalytic reactivity. With stearic acid (SA) modification, FePt@Au/Cu@SA can enter cancer cell through endocytosis, SA could fuse with the cell membrane to release FePt@Au/Cu, when FePt@Au/Cu decomposed, it could release Cu+ and e-, reduced O2 to form H2O2, then generated •OH by Fenton-like reaction. FePt@Au/Cu had better catalytic reactivity than Cu or FePt@Cu. Besides, FePt@Au/Cu was a biodegradable material, could be excreted from the body through urine metabolism to avoid accumulation of materials.

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