敗血症，是造成加護病房中病人死亡的主要原因之一。根據統計，在美國每年有超過七十萬人以上罹患敗血症，當中並約有215,000名病人因此而死亡。過去研究指出，氧化性壓力與敗血症所引發的多器官衰竭及死亡有密切相關性。芝麻油是從Sesamum indicum L.的種子中所提煉而成，具有高度的穩定性，一直以來都被認為是適合食用的油脂類。近年來研究發現芝麻油具有強效的抗氧化作用，能有效降低氧化性壓力，並因此改善內毒素血症所引發之肝臟傷害；然而芝麻油是否可以藉由減緩氧化性傷害，來對抗敗血症所引發的肝臟傷害仍不清楚。因此，本研究目的將探討芝麻油對大鼠敗血症所引發敗血症之保護作用及可能的作用機制。大鼠於灌食芝麻油七天後(4 ml/kg/day)進行盲腸結紮穿刺術誘導敗血症，並於12小時後記錄大鼠之存活率及評估肝臟傷害情形；測量脂質過氧化作用、羥自由基、過氧亞硝基物、超陰氧離子生成，一氧化氮含量及血中尿酸含量；此外，利用西方點墨轉漬法分析NADPH氧化酵素、黃嘌呤氧化酵素及誘導型一氧化氮合成酵素之蛋白質表現量。結果顯示，大鼠經盲腸結紮穿刺術誘導敗血症後，芝麻油能明顯增加存活率、有效改善肝臟傷害情形、降低血中及肝臟中脂質過氧化反應、減少羥自由基、過氧亞硝基物、超陰氧離子及一氧化氮含量，並降低血中尿酸含量，抑制NADPH氧化酵素、黃嘌呤氧化酵素及誘導型一氧化氮合成酵素之活性。因此，本研究結論，芝麻油可能透過減少反應氧化物質以及一氧化氮的生成，進而減緩敗血症大鼠之氧化性壓力，並達到保護肝臟的作用。

　Sepsis is one of the major causes of death reported in intensive care units. It estimates that more than 700,000 people suffered from sepsis with acute organ failure and 215,000 patients died of sepsis every year in the United State. Oxidative stress is known to involve in the development of organ fail-ure and death in sepsis. Sesame oil, derived from the plant species Sesamun indicum L., has been suggested as a potent antioxidant. Sesame oil potently attenuates oxidative stress and hepatic injury in endotoxemia; however, its ef-fect on sepsis-associated hepatic injury is still unclear. Therefore, the aim of this study was to examine the protective effect and possible mechanism of sesame oil on sepsis in rats. Sepsis was induced by cecal ligation and puncture. Sesame oil (4 ml/kg, orally) was given daily for one week, and survival rate was recorded and parameters were determined twelve hours after cecal liga-tion and puncture. Lipid peroxidation, hydroxyl radical, peroxynitrite, super-oxide anion, uric acid, and nitrite levels were determined in rats with sepsis. The expression of xanthine oxidase, NADPH oxidase, or inducible nitric ox-ide synthase was analysed by western blot. In addition, hepatic injury was also assessed by blood biochemistry and by histological examination. Sesame oil significantly increased survival rate and attenuated hepatic injury in septic rats. Sesame oil decreased lipid peroxidation, hydroxyl radical, peroxynitrite, superoxide anion, uric acid, and nitric oxide levels in both blood and hepatic tissue. In addition, the expression of xanthine oxidase, NADPH oxidase, and inducible nitric oxide synthase was markedly reduced. Therefore, sesame oil may protect against oxidative stress-associated hepatic injury by reducing production of reactive oxygen species and nitric oxide in septic rats.

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