腫瘤及創傷對人類來說是非常嚴重的威脅，而其高溫治療法也日新月異的在進步，近幾年來，電磁熱療法的發展為病人帶來一線署光。本研究設計兩種新型內科兩段式治療針及外科臟器切除矩陣針，並使用交流的磁場加熱做為感磁部分之不鏽鋼針連帶的成功造成組織燒灼，此種療法屬於所謂的高溫療法(thermotherapy)。體外實驗的部分驗證了該不鏽鋼針在交流磁場下具備使組織燒灼或使血液凝結的溫度，動物實驗則成功應用此種針造成目標組織燒灼及臟器無血切除。

本研究設計了電磁熱療儀器，內含一個溫度回饋系統，可以準確的利用交流磁場快速的加熱特殊針具到42、 60及80oC並探討加熱溫度及加熱時間對於組織燒灼範圍的影響，同時，利用豬肝組織建立了一套溫度於組織內之分布模式，此結果也應用在針具的設計。此外，利用鐵氟龍材料高溫鍍層於針具表面，也成功防止針具與組織於高溫燒灼下互相沾黏。

動物實驗則成功的利用內科用兩段式加熱針經超音波導引置針，燒灼兔子之肝臟，且術後沒有任何併發症。另一方面，利用外科臟器切除矩陣針也成功將兔子之肝臟及豬之肝臟、脾臟及胰臟無血切除，術後皆存活並沒有任何併發症，於術後兩周再度開腹觀察，其臟器傷口也沒有任何化膿及發炎反應。驗證本療法的可行性。

研究目標除了利用電磁熱療儀器治療癌症及創傷外，目的是將此療法順利應用到臨床醫學上。所以可以預期的是由於本療法具備局部治療的優點，如果本療法運用在臨床上，病人在治療過程中可以減輕痛苦減少副作用，本新式療法在於治療惡性腫瘤及臟器創傷上具有極大的潛力。

Cancer and trauma are still major threats to people, and therapy for these threats needs further improvement. The use of electromagnetic thermotherapy systems in surgery offers new hope for these patients. We conducted in vitro and in vivo experiments to assess the feasibility of this new form of thermotherapy.
In our experiments, a two-part needle was used for minimal invasive surgery, and a needles array was used for organ resection surgery. We developed a system which can generate a high-frequency alternation magnetic field designed to induce a localized temperature increase induced by inserting needles into the target tissue. To prevent overheating, a feedback temperature control system was successfully developed to keep the needles at a constant temperature. First, for in vitro tests, the relationship between the coagulation zone and the temperature and time factors were investigated. The needles were coated with Teflon to prevent them from sticking to the tissue. By using a feedback temperature control system, the needles could be heated up to specific temperatures, 42, 60 and 80oC, respectively. With this approach, we found the temperature and time necessary for coagulation in both minimal invasive surgery and in organ resection surgery.
For in vivo tests, in an internal medicine environment, a New Zealand white rabbit’s liver was coagulated using a two-part needle. In the organ resection surgery, the liver of a New Zealand white rabbit and a Lan-Yu pig’s liver, spleen and pancreas were resected using the needle array.
The experiments showed that by inserting the two-part needle and needles array into the target tissue, applying our electromagnetic thermotherapy system resulted in coagulation in the liver and resection of the organs without bleeding, which is very promising for further clinical use.

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