近年來，口腔癌的發生率一直有上升的趨勢，這個類別的癌症大多發生在男性身上。加上它的死亡率一直以來都是男性國人裡均高居於前四名，並且口腔癌的發生率更是全球之冠，因此口腔癌是嚴重威脅男性的生命健康。但是在癌症初期階段被發現並給予治療的話，與其它癌症相比之下存活率也高出許多，因此早期診斷出口腔癌一直是醫學界希望達到的目標。然而目前主流的診斷方式都有其缺點，無法兼顧精確度與便利性，甚至需要侵入方式診斷。在本報告中，我們將發展一套利用內生自發螢光作為口腔癌偵測的方法，因此這套系統具有安全、非侵入性和快速檢測的特性我們希望藉由這套系統，提高男性們在早期發現口腔癌的機會。

在本研究中，我們使用激發內生自發螢光的技術進行不同的動物實驗，並且進一步探討不同生理狀態、正常組織和變異組織的內生自發螢光量的多寡，從早期使用光譜儀測量到最後使用成像系統測量各不同生理狀態的組織，並分析這些組織的自發螢光。我們除了使用不同濃度自發螢光的水溶液了解螢光的亮度與濃度之間的關係外，並且測量了不同生理狀態的老鼠間螢光的亮度差異，最後我們還分析正常組織和變異組織間螢光的亮度。

In recent years, the incidence of oral cancer has continued an upward trend, this category of cancer occurs mostly in men. And its mortality rate in men has always been a high living in the top four, the incidence of oral cancer is highest in the world; threaten seriously male life and health. But in the early stages of cancer was discovered and given the treatment, the survival rates compare with other cancer is much higher, so early diagnosis of oral cancer has been the medical community want to achieve. However, the current mainstream diagnostic methods has shortcoming, cannot take into account the accuracy and convenience, or even requires invasive way to diagnostic. In this report, we will develop a set of using the endogenous auto-fluorescence as methods of oral cancer detection, and a characteristic of this system is safe, non-invasive and rapid detection of the features. We hope that through this system to improve opportunities for people to early detection of oral cancer.
In this paper, we use technology to excite the endogenous auto-fluorescence in different animal experiments, to find out more about the amount of emitted auto-fluorescence on different physiological states, normal and abnormal tissues, form the early use of the spectrometer of the different physiological states of these tissue and analysis a amount of auto-fluorescence. In addition to we used different concentration of solution to know the relationship between the amount of light and concentration for auto-fluorescence, and measuring in disparity physiological states of mice to observe fluorescent brightness. Finally, we also analyses the fluorescence between normal tissues and abnormal tissue of mice.

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