| 研究生: |
呂彥擇 Lu, Yen-Tse |
|---|---|
| 論文名稱: |
探討 MSP58 在 TGF-β/Smad 訊息傳遞路徑中的潛在調控機制 To study the potential regulatory mechanisms of MSP58 in TGF-β/Smad signaling pathway |
| 指導教授: |
林鼎晏
Lin, Ding-Yen |
| 學位類別: |
碩士 Master |
| 系所名稱: |
生物科學與科技學院 - 生物科技與產業科學系 Department of Biotechnology and Bioindustry Sciences |
| 論文出版年: | 2025 |
| 畢業學年度: | 113 |
| 語文別: | 英文 |
| 論文頁數: | 62 |
| 中文關鍵詞: | 腫瘤生成 、58-kDa微小球蛋白 、轉化生長因子β |
| 外文關鍵詞: | Tumorigenesis, MSP58, TGF-β |
| 相關次數: | 點閱:3 下載:0 |
| 分享至: |
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Agricola E, Randall RA, Gaarenstroom T, Dupont S, Hill CS. Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Mol Cell. 2011 Jul 8;43(1):85-96. doi: 10.1016/j.molcel.2011.05.020. PMID: 21726812.
Agricola, E., Randall, R.A., Gaarenstroom, T., Dupont, S., and Hill, C.S.
Akiyoshi, S., Inoue, H., Hanai, J., Kusanagi, K., Nemoto, N., Miyazono, K., and Kawabata,M. c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. Journal of Biological Chemistry 274, 35269-35277, 1999.
Annual review of immunology 32, 51-82, 2014.
Aucagne, K., Uroin, N., Paggetti, Lagrange, B., Largeot, A., Hammann, A., Bataille, A., Martin, L., Yan, K.P., Fenaux, P., Losson, R., Solary, E., Bastie, J.N., and Delva, L. Transcription intermediary factor l is a tumor suppressor in mouse and human chronic myelomonocytic leukemia. Journal of Clinical Investigation 121, 2361-2370, 2011.
Bader, A.G., Schncider, M.L., Bister, K., and Hartl M. TOJ3, a target of the v-Jun transcription factor, encodes a protein with transforming activity related to human microspherule protein 1 (MCRS1). Oncogene 20, 7524-35, 2001.
Batlle, E., and Massagué, J. Transforming Growth Factor-ß Signaling in
Benavides, M., Lai-Fong Chow-Tsang., Zhang, J., and Zhong, H. The novel interaction between microspherule protein MSP58 and ubiquitin E3 ligase EDD regulates cell cycle progression. Biochimica et biophysica acta 1833, 21-32, 2013.
Blank, U., and Karlsson, S. The role of Smad signaling in hematopoiesis and translational hematology. Journal of Leukemia 25, 1379-1388, 2011.
Boudrez, A., Beullens, M., Groenen, P., Van Eynde, A., Vulsteke, V., Jagiello, I., Murray, M., Krainer, A.R., Stalmans, W., and Bollen, M. NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. Journal of Biological Chemisty 275, 25411-25417, 2000.
Boutanquoi, P.M., Burgy, O., Beltramo, G., Bellaye, P.S., Dondaine, L., Marcion, G., Pommerolle, L., Vadel, A., Spanjaard, M., Demidov, O., Mailleux, A., Crestani, B., Kolb, M., Garrido, C., Goirand, F., and Bonniaud, P. TRIM33 prevents pulmonary fibrosis by impairing TGF-ß1 signalling. The European respiratory journal 55, 1901346, 2020.
Brown, A.L., Lee, C.H., Schwarz, J.K., Mitiku, N., Piwnica-Worms, H., and Chung, J.H. A human Cdsl-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proceedings of the National Academy of Sciences of the United States of America 96, 3745-3750, 1999.
Bruzzinski, C.J., Riordan-Johnson, M., Nordby, E.C., Suter, S.M., and Gelehrter, T.D.Isolation and characterization of the rat plasminogen activator inhibitor-1 gene. Journal of Biological Chemistry 265, 2078-2085, 1990.
Cell 147, 565-576, 2011.
Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America 102, 2703-6, 2005.
Chaffer, C.L., Thompson, E.W., and Williams, E.D. Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs 185, 7-19, 2007.
Chan, H.M., and La Thangue, N.B. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. Journal of Cell Science 114, 2363-2373, 2001.
Chen, J., Li, Q., An, Y., Lv, N., Xue, X., Wei, J., Jiang, K., Wu, J., Gao, W., Qian, Z., Dai, C., Xu, Z., and Miao, Y. CEACAM6 induces epithelial-mesenchymal transition and mediates invasion and metastasis in pancreatic cancer. International journal of oncology 43, 877-885. 2013.
de Caestecker, M.P., Piek, E., and Roberts, A.B. Role of transforming growth factor-beta signaling in cancer. Journal of National Cancer Institute 92, 1388-1402, 2000.
Demy, D.L, Tauzin, M., Lancino, M., Le Cabec, V., Redd, M., Murayama, E.., Maridonneau-Parini, I., Trede, N., and Herbomel, P. Trim33 is essential for macrophage and neutrophil mobilization to developmental or inflammatory cues. Journal of cell science 130, 2797-2807. 2017.
Developmental cell 10, 685-686, 2006.
Doisne, J.M., Bartholin, L., Yan, K.P., Garcia, C.N., Duarte, N., Le Luduec, J.B., Vincent, D., Cyprian, F., Horvat, B., Martel, S., Rimokh, R., Losson, R., Benlagha, K., and Marie, J.C. iNKT cell development is orchestrated by different branches of TGF-ß signaling. The Journal of experimental medicine 206, 1365-1378, 2009.
Dupont, S., Mamidi, A., Cordenonsi, M., Montagner, M., Zacchigna, L.., Adorno, M., Martello, G., Stinchfield, M.J., Soligo, S., Morsut, L., Inui, M., Moro, S., Modena, N., Argenton, F., Newfeld, S.J., and Piccolo, S. FAM/USP9x, a deubiquitinating enzyme essential for TGF-B signaling, controls SmadA monoubiquitination. Cell 136, 123-135, 2009.
Dupont, S., Zacchigna, L.., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., and Piccolo, S. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 121, 87-99, 2005.
European journal of biochemistry 253, 734-742, 1998.
Fawal, M.A., Brandt, M., and Djouder, N. MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation. Developmental cell 33, 67-81,
Fehrholz, M., Speer, C.P., and Kunzmann, S. Caffeine and rolipram affect Smad signalling and TGF-ß1 stimulated CTGF and transgelin expression in lung epithelial cells. PloS One 9, e97357, 2014.
Feng, X.H., and Derynck, R. Specificity and versatility in tgf-beta signaling through Smads. Annual Review of Cell Developmental Biology 21, 659-693, 2005.
Gentry, L.E., Webb, N.R., Lim, G.J., Brunner, A.M., Ranchalis, J.E., Twardzik, D.R., Lioubin, M.N., Marquardt, H., and Purchio, A.F. Type 1 transforming growth factor beta: amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells. Molecular and cellular biology 7,3418-3427, 1987.
Gordon, K.J., and Blobe, G.C. Role of transforming growth factor-beta superfamily signaling pathways in human disease. Biochimica et Biophysica Acta 1782, 197-228, 2008.
Guo, J., Qin, W., Xing, Q., Gao, M., Wei, F., Song, Z., Chen, L., Lin, Y., Gao, X., and Lin, Z. TRIM33 is essential for osteoblast proliferation and differentiation via BMP pathway. Journal of cellular physiology 232, 3158-3169, 2017.
Hammet, A., Pike, B.L., McNees, C.J., Conlan, L.A., Tenis, N., and Heierhorst,
He, W., Dorn, D.C., Erdjument-Bromage, H., Tempst, P., Moore, M.A., and Massagué, J. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGF-B pathway. Cell 125, 929-941, 2006.
Heldin, C.H., and Moustakas, A. A new twist in Smad signaling.
Hesling, C., Fattet, L., Teyre, G., Jury, D., Gonzalo, P., Lopez, J., Vanbelle, C., Morel, A.P., Gillet, G., Mikaelian, I., and Rimokh, R. Antagonistic regulation of EMT by TIF 1gamma and Smad4 in mammary epithelial cells. European Molecular Biology Organization Reports12, 665-672, 2011.
Hofmann, K., and Bucher, P. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends in Biochemical Sciences 20, 347-349,1995.
Hsu, C.C., Chen, C.H., Hsu, T.I., Hung, J.J., Ko, J.L., Zhang, B., Lee, Y.C., Chen, H.K., Chang, W.C., and Lin, D.Y. The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF). Biochimica et biophysica acta 1843, 565-79, 2014.
Hsu, C.C., Lee, Y.C., Yeh, S.H., Chen, C.H., Wu, C.C., Wang, T.Y., Chen, Y.N., Hung, L.Y., Liu, Y.W., Chen, H.K., Hsiao, Y.T., Wang, W.S., Tsou, J.H., Tsou, Y.H., Wu, M.H., Chang, W.C., and Lin, D.Y. 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. The Journal of biological chemistry 287, 22533-48, 2012.
Huang, C.J., Lyu, X., and Kang, J. The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development. Cell cycle 22, 619-632, 2023.
Immunity and Cancer. Immunity 50, 924 940, 2019.
Itoh, S., Itoh, F., Goumans, M.J., and Ten Dijke, P. Signaling of transforming growth factor-beta family members through Sad proteins. European journal of biochemistry 267, 6954 6967, 2000.
IUBMB Life 55, 23-27, 2003.
Ivanova, A.V., Ivanov, S.V. and Lerman, M.L. Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins. Cellular and molecular life sciences 62, 471-84, 2005.
J. FHA Domains as Phospho-Threonine Binding Modules in Cell Signaling.
Kalluri R. EMT: when epithelial cells decide to become mesenchymal-like cells.
Kalluri, R., and Weinberg, R. A. The basics of epithelial-mesenchymal transition. The Journal of clinical investigation 119, 1420-1428, 2009.
Kassem, L., Deygas, M., Fattet, L.., Lopez., J., Goulvent, T., Lavergne, E.., Chabaud, S., Carrabin, N., Chopin, N., Bachelot, T., Gillet, G., Treilleux, I., and Rimokh, R. TIF ly interferes with TGFß1/SMAD4 signaling to promote poor outcome in operable breast cancer patients. BMC cancer 15, 453, 2015.
Kotobuki, Y., Tonomura, K., and Fujimoto, M. Transcriptional intermediary factor 1 (TIF1) and anti- TIF1γantibody-positive dermatomyositis. Immunological medicine 44, 23-29, 2021.
Kraning-Rush, C.M., Califano, J.P., and Reinhart-King, C.A. Cellular traction stresses increase with increasing metastatic potential. Plos One 7, e32572, 2012.
Kulkarni, A., Oza, J., Yao, M., Sohail, H., Ginjala, V., Tomas-Loba, A., Horejsi, Z., Tan, A.R., Boulton, S.J., and Ganesan, S. Tripartite Motif-containing 33 (TRIM33) protein functions in the poly (ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein. J Biol Chem 288, 32357-32369, 2013.
Ligr M, Wu X, Daniels G, Zhang D, Wang H, Hajdu C, Wang J, Pan R, Pei Z, Zhang L, Melis M, Pincus MR, Saunders JK, Lee P, Xu R. Imbalanced expression of Tif1γ inhibits pancreatic ductal epithelial cell growth. Am J Cancer Res. 2014 May 26;4(3):196-210. PMID: 24959375; PMCID: PMC4065401.
Lin, W., Zhang, J., Zhang, J., Liu, X., Fei, Z., Li, X., Davidovic, L., Tang, Z., Shen, L., Deng, Y., Yang, A., Han, H., Zhang, X., and Yao, L. RNAi-mediated inhibition of MSP58 decreases tumor growth, migration and invasion in a human glioma cell line. Journal of cellular and molecular medicine 13, 4608-22, 2009.
Liu, M.X., Zhou, K.C., and Cao, Y. MCRSI overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer. Molecular cancer 13, 245, 2014.
Liu, X., Xing, Y., Yuen, M., Yuen, T., Yuen, H., and Peng, Q. Anti-Aging Effect and Mechanism of Proanthocyanidins Extracted from Sea buckthorn on Hydrogen Peroxide-Induced Aging Human Skin Fibroblasts. Antioxidants 11, 1900, 2022.
Massagué J. TGF-ß in Cancer. Cell 134, 215-230, 2008.
Massagué J. TGF-ß signaling in context. Nature reviews. Molecular cell biology 13, 616-630, 2012.
McAvera RM, Crawford LJ. TIF1 Proteins in Genome Stability and Cancer. Cancers (Basel). 2020 Jul 28;12(8):2094. doi: 10.3390/cancers12082094. PMID: 32731534; PMCID: PMC7463590.
Mendez, M.G., Kojima, S., and Goldman, R.D. Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 1838-1851, 2010.
Meroni, G., and Diez-Roux, G. TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases. Bioessays 27, 1147-1157, 2005.
Mullen, A.C., Orlando, D.A., Newman, J.J., Lovén, J., Kumar, R.M., Bilodeau,
Nagaraj, N.S., and Datta, P.K. Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert opinion on investigational drugs
Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki,K., Hanai, J., Heldin, C.H., Miyazono, K., and ten Dijke, P. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. European Molecular Biology Organization Journal 16, 5353-5362, 1997.
Okumura, K., Zhao, M., Depinho, R.A., Furnari, F.B. and Cavenee, W.K.
Oncogene 35, 867-877, 2016.
Padua D, Massagué J. Roles of TGFbeta in metastasis. Cell Res. 2009 Jan;19(1):89-102. doi: 10.1038/cr.2008.316. PMID: 19050696.
Peinado, H., Quintanilla, M., and Cano, A. Transforming growth factor beta-l induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. The Journal of biological chemistry 278, 21113-21123, 2003.
Petit, V., Parcelier, A., Mathé, C., Barroca, V., Torres, C., Lewandowski, D., Ferri, F., Gallouêt, A.S., Dalloz, M., Dinet, O., Boschetti, G., Vozenin, M.C., and Roméo, P. H. TRIM33 deficiency in monocytes and macrophages impairs resolution of colonic inflammation. EbioMedicine 44, 60-70, 2019.
Pommier, R.M., Gout, J., Vincent, D.F., Alcaraz, L.B., Chuvin, N., Arfi, V., Martel, S., Kaniewski, B., Devailly, G., Fourel, G., Bernard, P., Moyret-Lalle, C., Ansieau, S., Puisieux, A., Valcourt, U., Sentis, S., and Bartholin, L. TIF ly Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability. Cancer research 75, 4335-4350, 2015.
Privette, L.M., and Petty, E.M. CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis. Translational Oncology 1, 57-64, 2008.
Qi, G., Lu, G., Yu, J., Zhao, Y., Wang, C., Zhang, H., and Xia, Q. Up-regulation of TIF1γby valproic acid inhibits the epithelial mesenchymal transition in prostate carcinoma through TGF-B/Smad signaling pathway. European journal of pharmacology 860, 172551, 2019.
Quéré, R., Saint-Paul, L., Carmignac, V., Martin, R.Z., Chrétien, M.L., Largeot, A., Hammann, A., Pais de Barros, J.P., Bastie, J.N., and Delva, L. TIF IY regulates the TGF-ß1 receptor and promotes physiological aging of hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America 111, 10592-10597, 2014.
Recrutment of TIF ly to Chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Molecular Cell 43,85-96,2011.
Ren, Y., Busch, R.K., Perlaky, L., and Busch, H. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120.
S., Reddy, J., Guenther, M.G., DeKoter, R.P., and Young, R.A. Master transcription factors determine cell-type-specific responses to TGF-ß signaling.
Saharinen, J., Hyytiäinen, M., Taipale, J., and Keski-Oja, J. Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. Cytokine & growth factor reviews 10, 99-117, 1999.
Scolnick, D.M., and Halazonetis, T.D. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 406, 430-435, 2000.
Shi, H., Li, S.J., Zhang, B., Liu, H.L., and Chen, C.S. Expression of MSP58 in human colorectal cancer and its correlation with prognosis. Medical oncology 29, 3136-42, 2012.
Sun, L., Vin, H., and Li, H. GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-ß releasing. Oncotarget 7, 42826-42836, 2016.
Sun, Z., Hsiao, J., Fay, D.S., and Stern, D.F. Rad53 FHA domain associated with phosphory lated Rad9 in the DNA damage checkpoint. Science 281, 272-274, 1998.
The Journal of clinical investigation 119, 1417-1419, 2009.
Thiery, J.P., Acloque, H., Huang, R.Y., and Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890, 2009.
Travis, M.A., and Sheppard, D. TGF-B activation and function in immunity.
Tsai, J.H., and Yang, J. Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes & development 27, 2192-2206, 2013.
Viéovac, L., and Aplin, J.D. Epithelial-mesenchymal transition during trophoblast differentiation. Acta anatomica 156, 202-216, 1996.
Wang, L., Tong, X., Zhou, Z., Wang, S., Lei, Z., Zhang, T., Liu, Z., Zeng, Y., Li, C., Zhao, J., Su, Z., Zhang, C., Liu, X., Xu, G., and Zhang, H.T. Circular RNA hsa_ circ_0008305 (circPTK2) inhibits TGF-f-induced epithelial-mesenchymal transition and metastasis by controlling TIF1-y in non-small cell lung cancer. Molecular cancer 17, 140, 2018.
Wang, L., Yang, H., Lei, Z., Zhao, J., Chen, Y., Chen, P., Li, C., Zeng, Y., Liu,
Westerholm-Parvinen, A., Vernos, I., and Serrano, L. Kinesin subfamily UNC104 contains a FHA domain: boundaries and physicochemical characterization. Federation of European Biochemical Societies Letters 486, 285-290, 2000.
Xu, F., Liu, C., Zhou, D., and Zhang, L. TGF-B/SMAD Pathway and Its Regulation in Hepatic Fibrosis. The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society 64, 157-167, 2016.
Xue, J., Chen, Y., Wu, Y., Wang, Z., Zhou, A., Zhang, S., Lin, K., Aldape, K., Majumder, S., Lu, Z., and Huang, S. Tumor suppressor TRIM33 targets nuclear B-catenin degradation. Nature communications 6, 6156, 2015.
Yang, C.P., Chiang, C.W., Chen, C.H., Lee, Y.C., Wu, M.H., Tsou, Y.H., Yang, Y.S., Chang, W.C., and Lin, D.Y. Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58). Journal of biomedical science 22, 33, 2015.
Yang, C.P., Kuo, Y.L., Lee, Y.C., Lee, K.H., Chiang, C.W., Wang, J.M., Hsu, C.C., Chang, W.C., and Lin, D.Y. RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription. Biochemical and biophysical research communications 478, 873-880, 2016.
Yu, C., Ding, Z., Liang, H., Zhang, B., and Chen, X. The Roles of TIF1γin Cancer. Frontiers in oncology 9, 979, 2019.
Z., Liu, X., and Zhang, H.T. Repression of TIF 1-y by SOX2 promotes TGF -B-induced epithelial-mesenchymal transition in non-small-cell lung cancer.
Zeisberg, M., and Neilson, E.G. Biomarkers for epithelial-mesenchymal transitions. The Journal of clinical investigation 119, 1429-1437, 2009.
Zhai, X., Wu, Y., Zhang, D., Chong, T., and Zhao, J. Knockdown of MSP58 inhibits the proliferation and metastasis in human renal cell carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 91, 54 59, 2017.
Zhang, J., van der Zon, G., Ma, J., Mei, H., Cabukusta, B., Agaser, C.C., Madunic, K., Wuhrer, M., Zhang, T., and Ten Dijke, P. ST3GAL5-catalyzed gangliosides inhibit TGF-ß-induced epithelial-mesenchymal transition via TBRI degradation. The EMBO journal 42, e110553, 2023.
Zhao, H., Wei, J., and Sun, J. Roles of TGF-ß signaling pathway in tumor microenvironment and cancer therapy. International immunopharmacology 89, 107101, 2020.
Zhong, M., Zhang, X., Li, B.., Chen, C.S., Ji, G.L., Li, S.X., Bi, D.Q., Zhao, Q.C., and Shi, H. Expression of MSP58 in hepatocellular carcinoma. Medical oncology 30, 539, 2013.
校內:2030-08-20公開