本論文之研究包含兩個部分，第一部分是銀奈米立方體於不同金屬鏡像上之特性研究，透過研究1mm金屬塊材與蒸鍍80nm的金屬薄膜發現鋁塊材基板與鋁薄膜基板所得之Raman增顯因子相差1000倍。藉由紫外光/可見光光譜及XPS元素分析得知，因氧化鋁生成於鋁金屬表面使得表面電漿共振的強度隨著鋁鏡像基板之厚度上升而增加；而因為氧化銀生成於銀鏡像基板表面所以造成其SERS增顯因子小於金鏡像基板。最後利用自組裝單分子層技術將1,2-ethanedithiol創造銀奈米立方體與金屬鏡像之間隔層，由拉曼光譜的結果顯示間隔層可以提升金屬鏡像基板之增顯因子。
論文的第二部分是用模擬的方式來了解銀奈米立方體於金屬鏡像結構的增顯機制。模擬銀奈米立方體於玻璃基板與金屬基板之結果顯示在金屬鏡像基板確實可以比玻璃基板引發更強大的感應電場，且電場能量強度正比於金屬介電常數。而當銀奈米立方體與金屬基板之間有一層介電物質作為間隔層確實可以在間隔層區域產生強大的電場能量，最後模擬銀奈米立方體之間的距離，探討利用自組裝單分子層技術所得之SERS基板，主要的增顯機制是來自銀奈米立方體與金屬鏡像因表面電漿耦合所產生的感應電場。

In this thesis, we study on the application of silver nanocubes on the mirror of different metals in Surface-Enhanced Raman Scattering (SERS). The contents include two parts:
In the first section, the characteristics of the substrates which were fabricated by deposited silver nanocubes on the mirror of different metals were investigated. The Raman spectra showed that the enhancement factor of bulk aluminum substrate is larger than the enhancement factor of aluminum thin film substrate in three orders. The UV/vis spectra showed that the surface plasmon resonance between silver nanocube and metal substrate varied with the thickness of metal substrate. In addition, the X-ray photoelectron spectroscope (XPS) showed that the metal oxide was generated on the metal surface. It was found that aluminum oxide affects the surface plasmon resonance between silver nanocube and aluminum substrate. Furthermore, the silver oxide reduced the SERS performance, therefore gold substrate has higher enhancement factor than silver substrate. Since hot spots on a large scale can be generated by assembling silver nanocubes on the metal surface. Silver nanocubes are homogeneously assembled on the metal surface to lead strong optical field enhancement by using 1,2-ethylanedithiol as intermedium to link the interface of two metal surfaces to become hot spots.
In the second section, finite difference time domain method (FDTD) was used to simulate the surface plasmon resonance of silver nanocubes on different metallic mirrors. The result showed that silver nanocubes on metal substrate create larger hot spot area than glass substrate and the electron field energy is proportional to the dielectric constant of metal. The strong surface plasmon resonance can be created via using self-assembled monolayer to reduce the distance between silver nanocubes. Besides, the most important factor for SERS substrate is the distance between the silver nanocubes and the metal substrates.

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