我們可經由高選擇性的3CR反應來製備α,α'-iminodiacetic acid的對掌異構物，它的合成方法是將異腈、醛類和純的L-或D-胺基酸在甲醇當溶劑下反應。所得到的對掌異構物的絕對組態，是由合成過程中的胺基酸所決定。L-胺基酸產生一對掌異構物，那麼D-胺基酸所生成的必是另一個對掌異構物. 而且此3CR反應對於醛類、胺基酸的取代基大小相當的敏感。
　　在α-amino amides上，我們找到了Eschweiler-Clarke methylation反應的另一項發現。正常的Eschweiler-Clarke methylation是將氮上接上一個甲基，所使用的試劑是甲酸跟甲醛，但是在α-amino amides我們得到的卻是環化的產物，但是並非所有的α-amino amides對於甲酸甲醛的反應皆是得到環化產物，當結構上取代基的立體障礙過大的時候，還是會得到甲基化的產物的。

　　Several pairs of enantiomeric α,α'-iminodiacetic acid analogues were prepared separately by highly diastereoselective 3CR,which involves a reaction of an isocyanide, an aldehyde, and an enantiomerically pure amino acid in methanol. Synthesis of each of the enantiomers was controlled by the configuration of the amino acid；L-amino acid produces one enantiomer and D-amino acid generates the other. The diastereoselectivity of the 3CR is very sensitive to the substituent size of both aldehyde and enantiomerically pure amino acid.
　　An exception of Eschweiler-Clarke methylation was found for α-amino amides. Theα-amino amides on treatment with formaldehyde and formic acid produce cyclocondensation products, imidazolidin-4-ones, while N-methylation process becomes important when three substituents of theα-amino amides are very bulky. However, N-methylation is the only product for Eschweiler-Clarke methylation of the α-amino amides with N,N-disubstituted amides

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