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研究生： 余思瑤
Yu, Szu-Yao
論文名稱： 硫酸鈣/磷酸鈣複合材骨水泥性質研究（II）
Investigation of Properties of Calcium Sulfate/Calcium Phosphate Composite Cement (II)
指導教授： 陳瑾惠
Chern Lin, Jiin-Huey
共同指導教授: 朱建平
Ju, Chien-Ping
學位類別： 碩士
Master
系所名稱： 工學院 - 材料科學及工程學系
Department of Materials Science and Engineering
論文出版年： 2010
畢業學年度： 98
語文別： 中文
論文頁數： 123
中文關鍵詞： 骨水泥
外文關鍵詞： CBC
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    • 磷酸鈣骨水泥具有優良的生物相容性與適當的機械強度，並具有骨傳導性，但在人體內吸收速率相當慢使得骨細胞不易取代；而硫酸鈣骨水泥在體內溶解速率快，溶解的同時釋出鈣離子，鈣離子的釋出使得材料具有誘骨性，且硫酸鈣也具有良好的生物相容性；因此磷酸鈣和硫酸鈣混合後，利用硫酸鈣快速被吸收當作製造骨基質原料及產生空洞效果的特性，有利於新骨長入。
    本實驗第一部分探討54CBC、45CBC添加不同濃度的硬化劑以不同粉液比混合的各項性質比較。第二部份則針對第一部分中較佳性質的硬化劑條件，對複合材做短時間以及長時間浸泡Hanks’ solution各項性質變化之探討。
    54CBC複合材添加C-5 硬化劑， L/P-5，浸泡Hanks’ solution一天後具有較佳抗壓強度（約28MPa），並有適當的工作與硬化時間且不會崩解。而長時間浸泡下，由於孔隙率隨著浸泡時間增長而提高，導致複合材骨水泥的抗壓強度迅速下降，而在ISO 10993-5規範下細胞毒性測試結果均為80%以上。

    Calcium phosphate cement has excellent biocompatibility and adequate mechanical properties. It has also shown osteoconductive but has slow resorption in the human body. Calcium sulfate is a kind of materials that has excellent biocompatibility and fast resorption in human body. When calcium sulfate dissolved, the calcium ion was released that makes calcium phosphate composite with osteoinductive property. The absorpted calcium sulfate will be used as materials of bone matrix. It will make porous effect in composite. The newly formed bone integrates into the implant along with the pore and contacts directly with crystals of calcium phosphate.
    The first part of experiment is comparison of the property of 54CBC and 45CBC in view of the different concentration of hardening solution and the different liquid to powder ratio. The second part of experiment is to study composite soaking in Hanks’ solution with short time and long time of mechanism, mechanical properties and physical properties.
    54CBC with C-5 hardening solution, L/P-5 soaking in Hanks’ solution one day have superior compressive strength (about 28MPa). It also has adequate working/setting time and non-dispersion. In soaking long time, the porosity increase with soaking time increase, resulting that the compressive strength decrease quickly. Furthermore, the result of cytotoxicity (ISO 10993-5) show good biocompatibility.

    中文摘要 I Abstract II 誌謝 III 總目錄 IV 圖目錄 VIII 表目錄 XIII 第一章 總序論 1 1-1 生醫材料的定義 1 1-2 生醫材料的分類 2 1-2-1 依製造原料及化學組成分類 2 1-2-2 依活性分類 5 1-3 生醫材料之發展 9 1-4 生醫陶瓷 13 1-5 人體硬組織成分及性質簡介 16 1-6 骨科植入材的種類及性質要求 23 1-6-1 骨科植入材的來源種類 23 1-6-2 骨取代物在生物學上的要求 24 1-6-3 骨取代材的性質及製程要求 25 第二章 文獻回顧 27 2-1 硫酸鈣簡介 27 2-1-1 硫酸鈣的發展 27 2-1-2 硫酸鈣的性質簡介 28 2-1-3 硫酸鈣骨水泥的優點及缺點 31 2-2 磷酸鈣簡介 35 2-2-1 磷酸鈣鹽類生醫陶瓷的分類與發展 35 2-2-2 磷酸鈣鹽類的性質簡介 36 2-2-3 雙相磷酸鈣骨水泥 38 2-2-4 磷酸鈣骨水泥的優點與缺點 40 2-3 磷酸鈣系與硫酸鈣系形成之多相複合生醫材料 45 2-3-1 CaSO4･1/2H2O/ HA composite 45 2-3-2 CaSO4･1/2H2O/α-TCP composite 47 2-3-3 CaSO4･2H2O/α-TCP composite 48 2-3-4 TTCP / DCPA/CaSO4･1/2H2O composite 50 2-4 研究目的 57 第三章 實驗原理及步驟 58 3-1 實驗使用藥品 58 3-2 實驗步驟與分析方法 58 3-2-1 磷酸鈣與硫酸鈣複合材粉末製備 58 3-2-2 抗壓試片製作與強度測試 58 3-2-3 工作與硬化時間測量 59 3-2-4 pH值的量測 59 3-2-5 X-Ray diffraction（XRD）分析 60 3-2-6 Scanning Electron Microscopy（SEM）表面觀察 61 3-2-7 元素分佈分析（mapping）、EDS分析 62 3-2-8 孔隙度（Porosity）、重量損失測試 62 3-2-9 細胞毒性測試 63 第四章 結果與討論 71 4-1 複合材骨水泥添加不同濃度硬化劑浸泡人工體液（Simulated body fluid,SBF）一天後性質探討 71 4-1-1 複合材骨水泥工作及硬化時間測量結果 71 4-1-2 複合材浸泡SBF一天後抗壓強度分析 72 4-1-3 複合材浸泡SBF一天後XRD分析 73 4-1-4 複合材浸泡SBF一天後SEM微結構觀察 73 4-2 複合材骨水泥初始反應分析 83 4-2-1 複合材骨水泥崩解性測試 83 4-2-2 複合材浸泡SBF短時間的抗壓強度分析 83 4-2-3 複合材骨水泥反應初期pH值變化 84 4-2-4 複合材浸泡SBF短時間的XRD分析 85 4-2-5 複合材浸泡SBF短時間的SEM微結構觀察 86 4-3 複合材骨水泥長時間浸泡人工體液的性質分析 92 4-3-1 複合材骨水泥長時間浸泡SBF的抗壓強度分析 92 4-3-2 複合材長時間浸泡SBF的pH值變化 93 4-3-3 複合材骨水泥浸泡SBF長時間的XRD分析 94 4-3-4 複合材長時間浸泡SBF的SEM微結構觀察 95 4-3-5 複合材長時間浸泡SBF的孔隙率、重量損失 96 4-4 複合材骨水泥細胞毒性測試 106 第五章 結論 108 參考文獻 109

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