有許多因素影響子宮內授精的結果，包括身體和心理的影響。我們的研究目標在於評估一般生活品質或生育相關的生活品質與子宮內授精週期結果之間的關聯。在這項研究中，我們將時間因素納入考量，並利用 Kaplan-Meier 生存分析來評估Fertility Quality of Life (FertiQoL) 或 SF-36 分數與子宮內授精結果之間的關聯性。
這項研究是根據一項臨床隨機試驗的次級資料分析。我們使用了來自 AMIGOS 臨床試驗的去識別數據。這項臨床試驗在2010年到2012年間進行，執行機構為Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network。該試驗涵蓋了美國 12 個地點，並納入了900 名面臨不明原因不孕的參與者。
根據 AMIGOS 試驗的次級資料分析，我們發現Quality of Life (FertiQoL)分數與子宮內授精週期的結果之間沒有關聯，包括懷孕(化學懷孕)、臨床懷孕以及活產。然而，我們發現 SF-36 分數與化學懷孕之間存在正相關。結果顯示，SF-36心理分數與達到化學懷孕顯著相關（Hazard Ratio = 1.73），這意味著與SF-36 心理分數較差的群體相比，SF-36 心理分數較好的群體達到化學懷孕的機率增加了73%。同樣地，SF-36身體分數與達到化學懷孕（Hazard Ratio = 2.04）和活產（Hazard Ratio = 2.235）顯著相關，這意味著與 SF-36 身體分數較差的群體相比，SF-36 身體分數較好的群體達到化學懷孕和活產的機率增加了超過100%。

There are many factors, including physical and psychological influences, play a role in the outcomes of intrauterine insemination cycle. Our objective is to assess the association between the generic or fertility-related quality of life and intrauterine insemination cycle outcomes. In the study, we thoroughly considered time factors, and utilized of Kaplan-Meier survival analyses to evaluate the association between fertility-related quality of life or SF-36 score and intrauterine insemination cycle outcomes.
This study was a secondary data analysis of a randomized trial. We used deidentified data sourced from the AMIGOS clinical trial, conducted by the Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network from 2010 to 2012. This trial spanned 12 sites throughout the United States and included 900 participants grappling with unexplained infertility. (Trial registration: ClinicalTrials.gov NCT01044862.)
Based on the secondary data analysis of AMIGOS trial, we found no association between Fertility-quality of life score and intrauterine insemination cycle outcomes, including the time-to-achieved pregnancy (chemical pregnancy), time-to-clinical pregnancy, and time-to-live birth. However, we found positive association between SF-36 score and time-to-chemical pregnancy. The results revealed that the SF-36 mental component score was significantly associated with achieving chemical pregnancy (Hazard Ratio = 1.73), implying that compared with poor SF-36 mental component score group, a 73% increase of achieving chemical pregnancy for good SF-36 mental component score group. Similarly, the SF-36 physical component score was significantly associated with achieving chemical pregnancy (Hazard Ratio = 2.04) and live birth (Hazard Ratio = 2.235), implying that compared with poor SF-36 physical component score group, more than 100% increase of achieving chemical pregnancy and live birth for good SF-36 physical component score group.

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