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研究生：	范立群 Fan, Li-Chun
論文名稱：	藥物傳輸之微針頭設計 Design of a micro-needle for the dispensing of Drugs
指導教授：	呂宗行 Leu, Tzong-Shyng
學位類別：	碩士 Master
系所名稱：	工學院 - 航空太空工程學系碩士在職專班 Department of Aeronautics & Astronautics (on the job class)
論文出版年：	2013
畢業學年度：	101
語文別：	中文
論文頁數：	58
中文關鍵詞：	微管道、微針頭設計
外文關鍵詞：	Microchannel, Microneedle
相關次數：	點閱：90 下載：6
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本研究係使用CFDRC計算流體力學套裝軟體，在現有微機電設計組裝及製造的理念下，設計一支散佈微管道的針頭運用於藥物傳輸，在層流條件下分別針對微管道出口寬度、深寬比（aspect ratio）為影響各微管道出口流量的主要因素及影響，水力直徑範圍介於50至100 μm之間，流速訂為0.001 m/s，利用Bendib等人所推導管道設計公式，簡單的計算出A、B等2模式傳輸藥物針頭的幾何外型尺寸，而以A模組(平行板流理論)與B模組(管流理論)的模擬數據、流量比較值及標準差相互比較後，可以發現B模組所推導微針頭管道設計較A模組有較小誤差且比較符合理論值。

This study uses CFDRC Computational fluid dynamics software package, using process of fabrication and manufacturing concept from MEMS to design a micro-needle with many micro-channel to used in drug delivery. The outlet width and aspect ratio are the main factors to affect dispensing under laminar flow conditions. The hydraulic diameters in this study are between 50 to 100 μm. The flow inlet velocity is 0.001m/s. The microneedle design theory from Bendib is easy to calculate the size or module of micro-needle. According to the theory, we design two module to simulate. The results obtained from simulation indicate that model B is greater than model A.

摘要.................................................................................................................I 

Abstract..........................................................................................................II 

誌謝..............................................................................................................III 

目錄..............................................................................................................IV 

圖目錄..........................................................................................................VI 

表目錄..........................................................................................................IX 

符號說明.......................................................................................................X

第一章 緒論 .................................................................................................1

1.1  引言.................................................................................................1

1.2  文獻回顧.........................................................................................1

1.3  論文架構......................................................................................4

第二章 理論模式 ........................................................................................5

2.1 理論說明.........................................................................................5

2.2 軟體介紹.......................................................................................10

2.2.1 CFD-GEOM..................................................................11

2.2.2 CFD - ACE...................................................................11

2.2.3 CFD-VIEW...................................................................11

第三章 數值求解 ......................................................................................13

3.1 基本假設.......................................................................................13

3.2 網格架構.......................................................................................13

3.2.1 網格形式.............................................................................13

3.2.2 網格數.................................................................................15

第四章 結果與討論 ..................................................................................16

4.1 模擬個案敘述...............................................................................16

4.2  結果與討論...................................................................................17

第五章 結論與未來展望...........................................................................55

5.1 結論................................................................................................55

5.2 未來展望........................................................................................56

參考文獻.....................................................................................................57
 
圖目錄
圖 2- 1   CFDRC 之運算流程架構..........................................................12 圖 2- 2  結構性網格 ...............................................................................12 圖 2- 3  非結構性網格 ............................................................................12圖 3- 1  微針頭結構性網格建構............................................................14圖 4- 1  微針頭設計示意圖...................................................................16 圖 4- 2  模組A1微管道尺寸趨勢圖......................................................19 圖 4- 3  模組A1微管道流速趨勢圖......................................................19 圖 4- 4  模組A1微管道體積流率趨勢圖...............................................20圖 4- 5  模組A1微管道壓力趨勢圖.......................................................20圖 4- 6  模組A2微管道尺寸趨勢圖......................................................21 圖 4- 7  模組A2微管道流速趨勢圖......................................................21 圖 4- 8  模組A2微管道體積流率趨勢圖...............................................22圖 4- 9  模組A2微管道壓力趨勢圖.......................................................22圖 4-10  模組A3微管道尺寸趨勢圖......................................................23 圖 4-11  模組A3微管道流速趨勢圖......................................................23 圖 4-12  模組A3微管道體積流率趨勢圖...............................................24圖 4-13  模組A3微管道壓力趨勢圖.......................................................24圖 4-14  模組A4微管道尺寸趨勢圖......................................................25 圖 4-15  模組A4微管道流速趨勢圖......................................................25 圖 4-16  模組A4微管道體積流率趨勢圖...............................................26圖 4-17  模組A4微管道壓力趨勢圖.......................................................26圖 4-18  模組A5微管道尺寸趨勢圖......................................................27 圖 4-19  模組A5微管道流速趨勢圖......................................................27 圖 4-20  模組A5微管道體積流率趨勢圖...............................................28圖 4-21  模組A5微管道壓力趨勢圖.......................................................28圖 4-22  模組A6微管道尺寸趨勢圖......................................................29 圖 4-23  模組A6微管道流速趨勢圖......................................................29 圖 4-24  模組A6微管道體積流率趨勢圖...............................................30圖 4-25  模組A6微管道壓力趨勢圖.......................................................30圖 4-26  模組B1微管道尺寸趨勢圖......................................................31 圖 4-27  模組B1微管道流速趨勢圖......................................................31 圖 4-28  模組B1微管道體積流率趨勢圖...............................................32圖 4-29  模組B1微管道壓力趨勢圖.......................................................32圖 4-30  模組B2微管道尺寸趨勢圖......................................................33 圖 4-31  模組B2微管道流速趨勢圖......................................................33 圖 4-32  模組B2微管道體積流率趨勢圖...............................................34圖 4-33  模組B2微管道壓力趨勢圖.......................................................34圖 4-34  模組B3微管道尺寸趨勢圖......................................................35 圖 4-35  模組B3微管道流速趨勢圖......................................................35 圖 4-36  模組B3微管道體積流率趨勢圖...............................................36圖 4-37  模組B3微管道壓力趨勢圖.......................................................36圖 4-38  模組B4微管道尺寸趨勢圖......................................................37 圖 4-39  模組B4微管道流速趨勢圖......................................................37 圖 4-40  模組B4微管道體積流率趨勢圖...............................................38圖 4-41  模組B4微管道壓力趨勢圖.......................................................38圖 4-42  模組B5微管道尺寸趨勢圖......................................................39 圖 4-43  模組B5微管道流速趨勢圖......................................................39 圖 4-44  模組B5微管道體積流率趨勢圖...............................................40圖 4-45  模組B5微管道壓力趨勢圖.......................................................40圖 4-46  模組B6微管道尺寸趨勢圖......................................................41 圖 4-47  模組B6微管道流速趨勢圖......................................................41 圖 4-48  模組B6微管道體積流率趨勢圖...............................................42圖 4-49  模組B6微管道壓力趨勢圖.......................................................42圖 4-50  模組B7微管道尺寸趨勢圖......................................................43圖 4-51  模組B7微管道流速趨勢圖......................................................43 圖 4-52  模組B7微管道體積流率趨勢圖...............................................44圖 4-53  模組B7微管道壓力趨勢圖.......................................................44圖 4-54  模組B8微管道尺寸趨勢圖......................................................45 圖 4-55  模組B8微管道流速趨勢圖......................................................45 圖 4-56  模組B8微管道體積流率趨勢圖...............................................46圖 4-57  模組B8微管道壓力趨勢圖.......................................................46圖 4-58  模組B9微管道尺寸趨勢圖......................................................47 圖 4-59  模組B9微管道流速趨勢圖......................................................47 圖 4-60  模組B9微管道體積流率趨勢圖...............................................48圖 4-61  模組B9微管道壓力趨勢圖.......................................................48圖 4-62  模組B10微管道尺寸趨勢圖......................................................49 圖 4-63  模組B10微管道流速趨勢圖......................................................49 圖 4-64  模組B10微管道體積流率趨勢圖..............................................50圖 4-65  模組B10微管道壓力趨勢圖......................................................50圖 4-66  模組A1至A6流量比值分析圖....................................................53 圖 4-67  模組B5至B10流量比值分析圖.................................................53圖 4-68  模組B1至B4流量比值分析圖....................................................54. 
表目錄
表 4-1  分析模組幾何 .................................................................................18表 4-2     管道出口流量分析圖......................................................................52

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校內：2016-01-31公開
校外：2016-01-31公開

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