摘要
　　生醫材料的表面性質對生物相容性的研究是非常重要的，而長鏈的烷基硫醇可藉由化學鍵結吸附在金的表面形成緻密排列且具有方向性的自我聚集單分子層，此恰好提供一多樣末端結構與表面性質以作為材料表面與血液相容性之探討，因此利用其單一表面官能基的特性來探討各種不同性質對血液相容性的影響將有助於對血拴形成原因有所了解。本研究擬合成出具有–PO4H2及-OP(=O)(OH)OCH2CH2NH2官能基之硫醇並與末端基團為-CH3、-OH、-COOH、-PO3H2、NH2等硫醇在金上形成自我聚集單分子層，進行其表面性質與血液相容性之比較與探討。
　　由靜態接觸角實驗結果發現，末端為陰電性官能基的自我聚集單分子層，其酸性官能基上的氫在水中會解離使得材料變得更親水，在動態接觸角的遲滯現象方面，分子結構的立體效應或靜電作用力則會造成自我聚集單分子層紊亂的排列，ESCA的S2p圖譜的結果再次證實了這一點。
　　從血液相容性探討的結果我們可歸納出，帶有陰電性官能基的硫醇容易誘導血小板的吸附，而帶正電的材料表面之血液相容性相對較佳，不過就形態學而言，此研究合成出來的硫醇確實有改善金基材的血液相容性。

Abstract
　It still remains as an unsolved puzzle in terms of the role of interfacial or surface properties of artificial biomaterials in mediating interactions between these materials with biological environment. Various efforts have been undertaken to resolve this issue. Among these, self-assembled monolayer has been of focus. Due to the van der Waals force between the hydrocarbon chains as well as the strong binding between sulfur and gold substrate, the self-assembled monolayers (SAM) formed by the long chain alkanethiol has densely packed, and well-oriented characteristics. This technique could offer a surface with a wide range of chemical structures and surface properties for the studies of blood-materials interactions. Because of its well-defined surface chemical structure, the alkanethiol SAM on gold is employed as the model surface in this study to explore the relationships between the blood compatibility and various surface properties of substrate. Self-assembled monolayers on gold substrate using the thiols with different terminal functional groups, including lab-synthesized thiols of -PO4H2 and -OP(=O)(OH)OCH2CH2NH2, and thiols of -CH3, -OH, -COOH, -PO3H2, -NH2 are employed to draw a comparison between the surface characteristic and blood compatibility.
　Static contact angle measurement indicates the SAMs surface with negative charge terminal group will deprotonate in the water, making the materials hydrophilic. With regard to the hysteresis in the dynamic contact angle measurement, the steric effect and electrostatic interactions among the adsorbed alkanethiols lead to a less ordered packing on the SAM surface. The S2p ESCA spectra further confirm this hypothesis.
　Platelet adhesion test demonstrates the SAMs with negative charge terminal group induce platelet adhesion easily, while the material surface with positive charge functional group has a better blood compatibility. In terms of morphology of adherent platelets, the alkanethiols we synthesize in this study all demonstrate an improvement in the blood compatibility as compared to the bare gold substrate.

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