本論文中有四個研究主題，包括(1)一維β相氫氧化鐵奈米棒的合成方法，(2)一維孔洞型氧化鐵奈米棒的合成方法，(3)利用一維孔洞型氧化鐵奈米棒為基材在表面修飾聚電解質的研究，(4)利用孔洞型氧化鐵奈米棒填入異硫氰酸螢光素(FITC)並修飾聚電解質後成為奈米容器，研究胞飲作用中的釋放現象發展於奈米載體的應用。
首先，(1)我們使用三價鐵鹽類和尿素在去離子水溶液中迴流12個小時和控溫90~95℃中製備出一維β相氫氧化鐵奈米棒，所得的奈米棒尺寸、結構、組成成分和化學性質分別以穿透式電子顯微鏡(TEM)、薄膜式X光繞射分析儀(Thin-Film XRD)、高解析穿透式電子顯微鏡(HR-TEM)、掃描式電子顯微鏡(SEM)和傅立葉紅外線光譜儀(FT-IR)分析檢測。(2)接著將製備的一維β相氫氧化鐵前趨物鍛燒形成具有孔洞特性的氧化鐵奈米棒，並使用場發射掃描式電子顯微鏡(FE-SEM)和穿透式電子顯微鏡(TEM)觀察孔洞形態變化，以及使用高解析穿透式電子顯微鏡(HR-TEM)配合選區電子繞射(SAED)和同步幅射X光繞射分析儀(Synchrotron Radiation Powder XRD)分析鑑定得其組成是β相氫氧化鐵和α相三氧化二鐵兩者組成。(3)已製備的一維多孔洞性質氧化鐵奈米棒表面修飾上四層聚電解質：聚丙烯酸(PAA)和聚醚醯亞胺(PEI)作為奈米容器，並使用穿透式電子顯微鏡(TEM)和表面電位分析儀(Zeta-Potential)分析鑑定聚電解質的修飾結果。(4)最後我們將異硫氰酸螢光素(FITC)分子埋入修飾聚電解質膜奈米容器，藉由研究異硫氰酸螢光素分子在細胞內表現，我們使用螢光顯微鏡的觀察可知十五分鐘後異硫氰酸螢光素分子則開始釋放到細胞內。

There are four topics in my research. The first is the synthesized approach of the 1D β-FeOOH nanorods in aqueous solution. The FeCl3•6H2O and Urea in deionized water are fluxed in 12 hours and 90~95℃ to synthesize the 1D β-FeOOH nanorods, and then those nanprods are analyzed by the instruments, such as the TEM, Thin-Film XRD, HR-TEM , SEM, and FT-IR to confirm their sizes, structures, compositions, and chemical properties. The second is the synthesized approach of the 1-D porous iron oxide nanorods. The precursor “1-D β-FeOOH nanorods” is calcined to form the porous iron oxide nanorods, and then the porous shape of those nanorods are observed by using the FE-SEM and TEM. In the composition, a porous iron oxide nanorod consists of β-FeOOH and α-Fe2O3 and the composition of those porous nanorods are confirmed by using the HR-TEM equipped with SAED and the Synchrotron Radiation Powder XRD. The third is an assemble approach that the surface of the 1-D porous iron oxide nanorods are engineered with polyelectrolyte. The surface of those nanorods are engineered to deposit the four layers polyelectrolyte: Using polyacrylic acid(PAA) and polyethylene imine(PEI) as the nanocapsules. The quality of those nanorods is confirmed by using the TEM and Zeta-Potential. In the final topic, those porous iron oxide nonarods are loaded with fluorescein isothiocyanate (FITC), and are engineered with polyelectrolyte to shape the nanocapsules. However, the living cells are cultured with those nanocapsules. After 15 minutes, the activity of the living cells taking in the nanocapsules are observed by the fluorescence microscope. Finally, those approaches are developed in the application of bio-fields, and thus we will use those studying to investigate bio-field, such as the drug deliver in the future.

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