為了降低骨科手術術後感染的風險，因而本實驗進行抗菌型生醫陶瓷的探討，使用抗菌鹽類當添加劑加入具有良好生物相容性與骨誘導性的雙相磷酸鈣與硫酸鈣的複合材中，製作成塊狀生醫陶瓷。
本實驗使用金黃色葡萄球菌當抑菌圈測試實驗的菌種，測試抗菌型生醫陶瓷的抗菌效果。首先探討四種抗菌鹽類添加入複合材後的抗菌效果。然後選擇抗菌效果較好與溶解速率較慢的C型抗菌鹽類添加入複合材中，探討此生醫陶瓷的各種性質。為了延緩抗菌鹽類在Hanks’solution中的釋放，本實驗配製成含有高分子的磷酸氫二銨((NH4)2HPO4)硬化劑，簡稱為P1、P2及P3，與C型抗菌鹽類及複合材混合製作成塊狀生醫陶瓷。
本實驗發現隨著添加高分子的量增加，塊狀生醫陶瓷的抗菌效果維持天數也增長。由未添加高分子的只能維持1~2天，增加至3~7天。含P3高分子的C型生醫陶瓷除了於第7天有微小的抑菌圈出現外，在浸泡Hanks’solution 10天後的細胞毒性測試中，對NIH-3T3細胞亦無不良反應，細胞存活率達85%以上，說明了此抗菌型生醫陶瓷具有潛質應用於骨頭修損上。

關鍵字：抗菌鹽類;金黃色葡萄球菌;生醫陶瓷

In order to reduce the risk of postoperative infection in orthopedic surgery, thus this experiment investigation antibacterial properties of bioceramic, we select antimicrobial salts additive to has good biocompatibility and bone-induced of biphasic calcium phosphate and calcium sulfate composite, and made into a block bioceramic.
In this study, we select the Staphylococcus aureus strains as the zone of inhibition test experiments, to test the antibacterial effect of the bioceramics. First, we test the antibacterial effect of four antimicrobial salts into the composite. Then, we select have better antibacterial effect and slower dissolution rate of C-type antimicrobial salts add into the composite material to explore the various properties of the bioceramics. In order to delay the release of antimicrobial salts in Hanks’solution, this experiment is formulated into the polymer-containing diammonium phosphate ((NH4)2HPO4) hardener, referred to as P1, P2, and P3, and C-type antimicrobial salts and composite materials mixed into a block bioceramics.
This was found, as the block bioceramic add the amount of the polymer increased, the antibacterial effect of maintain number of days also increased. Not add any polymer for 1~2 days, and after add the amount of the polymer increased to 3~7 days. Bioceramics of P3 and C-type antimicrobial salts, had a small zone of inhibition in seven days, the cytotoxicity test in the tenth day, NIH-3T3 cells had no adverse reactions, cell viability was 85% or more, indicating this antibacterial bioceramics have the potential to be applied on bone repair damage.

Keywords: Antimicrobial salts;Staphylococcus aureus;Bioceramic

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