表面增強拉曼散射(Surface-enhance Raman scattering, SERS)軟式纖維濾紙基板具有良好的靈敏度能用來檢測單分子以及有毒物質。在本實驗中，首先以疏水基板進行SERS基板製作，並且找到了單寧酸與四氯金酸的最佳參數，以亞甲基藍和4-nitrothiophenol(4-NTP)進行量測，還有使用了氧化石墨烯作為前驅物，能夠均勻覆蓋表面，也成功消滅共振拉曼所產生的螢光。黑色溶液的氧化石墨烯會吸收入射光，導致從基板回去的散射光減少進而降低拉曼訊號的表現。
第二則是使用市售且價格便宜的銀膠沉積在纖維濾紙基板上使其基板具有SERS的效果。從銀膠的濃度及滴入次數的調整，找出最佳銀膠基板的參數，並且利用二次成長的濕化學合成技術以及半導體金屬二氧化錫對銀膠基板進行二次成長處理，由於原本的表面只有銀，經過二次成長金以及二氧化錫就讓表面多了奈米金以及表面變得粗糙不平整，處理過後L-AAH以及AuAgSnUV基板的拉曼強度大約可提升3倍。化學性吸附分子4-nitrothiophenol(4-NTP)能夠在近紅外雷射1064 nm拉曼系統底下還能夠擁有拉曼訊號。經過二次處理後的基板都能夠延緩氧化的效果，存放兩天還可以有70%的拉曼訊號，另外可以透過二氧化錫可光催化的特性使得基板可以降解有害染料孔雀石綠。

Surface-enhance Raman scattering (SERS) of fiber substrate has good sensitivity and can be used to detect single molecules and toxic substances. This SERS substrate first made as with a hydrophobic substrate synthesized with tannic acid and chloroauric acid, and measured with methylene blue and 4-nitrothiophenol (4-NTP). Graphene oxide, which is also used as a precursor can evenly cover the surface and successfully eliminate the fluorescence generated by resonance Raman. Low cost and commercially available Ag paste deposits it on the fiber filter paper substrate in order to produce the substrate have a SERS effect. The best Ag paste substrate parameters were found by adjustment of the concentration of and number of drops. Ag paste substrate had been second growth to make the surface more and the surface becomes rough and uneven. After the treatment, the SERS strength can be increased by about three times. The chemical enhance 4-nitrothiophenol (4-NTP) can also have a Raman signal under the NIR 1064 nm Raman system. After the second treatment, the substrate can defer to the degree of oxidation, and the SERS intensity also keeps at less 70% after two days of storage. In addition, malachite green can be degraded through the substrate synthesized by SnO2. Finally, because of using paper substrate which is soft materials, it can be detected on portable Raman system. Measurement can be done anytime, anywhere.

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