本研究選擇SDS/DTAB、SDS/TTAB、SDS/HTAB及STS/TTAB四種不同的陰/陽離子混合界面活性劑系統，探討具有相反電性頭基及不同碳鏈長度尾基的單鏈陰/陽離子界劑藉由靜電交互作用在水中自發形成陰陽離子液胞的區域，然後嘗試在液胞溶液中加入水溶性高分子，令其增稠及膠化，探討兩者之間的交互作用及相關疏水絮集現象，並擬以之做為開發藥物傳輸載體新劑型的基礎。在膠化的研究中選擇的液胞系統為SDS/HTAB = 9/1 ( V- )及STS/TTAB = 1/9 ( V+ )；水溶性高分子則包括羥基乙基纖維素( HEC，250 MR，P0 )、經疏水改質之羥基乙基纖維素( HMHEC，Plus 330，HMP0 )、三甲基銨衍生物( cat-HEC，JR 400，P+ )及二甲基十基銨衍生物( cat-HMHEC，LM 200，HMP+ )。液胞與高分子的混合溶液除了使用雷射光散射法粒徑及界面電位測定儀量測粒子特性外，也使用流變儀量測其交聯特徵。
　　由實驗結果建立了八個液胞與高分子交聯的相圖，並確立陰陽離子液胞溶液的增稠及膠化條件，將可做為後續研究之重要參考。此外，經由上述兩種帶電的液胞分別與帶電/不帶電、疏水性修飾/無疏水性修飾等四種高分子的交互作用結果，也增進了對靜電及疏水效應在分子間交互作用及絮集現象中扮演的角色的了解。

　In a preliminary work, spontaneous vesicle formation from four anionic-cationic mixed single-chained surfactant systems ( SDS/DTAB, SDS/TTAB, SDS/HTAM, and STS/TTAB ) were systematically studied by dynamic light scattering. The system parameters including surfactant concentration, ratio of anionic to cationic surfactant, number of carbon atoms in chains, and asymmetry in chain length of surfactants are involved. The gelation of two selected catanionic vesicles ( SDS/HTAB = 9/1 and STS/TTAB = 1/9 ) by four polymers ( HEC, HMHEC, cat-HEC, and cat-HMHEC ) was then studied using tube inversion and rheology.
　Eight phase maps were successfully established. They lend plausibility to exploiting new forms of vesicular drug delivery. Furthermore, the experimental results of the interactions between charged vesicles and polymers with and without charge, with and without hydrophobic modification also shed light on the roles the electrostatic and hydrophobic effects may play in gelation.

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