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研究生： 侯達鈞
Hou, Ta-Jyun
論文名稱： 以氰基丙烯酸異丁酯和氰基丙烯酸辛酯組成的牙根組織黏合劑的評估
Evaluations of root-tissue adhesives based on isobutyl cyanoacrylate and octyl cyanoacrylate
指導教授： 莊淑芬
Chuang, Shu-Fen
丁羣展
Ting, Chun-Chan
學位類別： 碩士
Master
系所名稱： 醫學院 - 口腔醫學研究所
Institute of Oral Medicine
論文出版年： 2024
畢業學年度： 113
語文別： 英文
論文頁數： 85
中文關鍵詞： 組織膠 、氰基丙烯酸酯黏著劑 、牙齦退縮 、牙齦美觀手術 、細胞毒性 、黏著強度 、光學同調斷層掃描（OCT）
外文關鍵詞： Tissue adhesive, Cyanoacrylate adhesive, Gingival recession, Mucogingival surgery, Cytotoxicity, Bond strength, Optical coherence tomography
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    • 中文摘要 I ABSTRACT III LIST OF TABLES XII LIST OF FIGURES XIII Chapter 1 Introduction 1 1.1. Wound closure techniques 1 1.2. Tissue adhesives 2 1.3. Cyanoacrylates adhesives 4 1.3.1. Reaction of cyanoacrylates adhesives 5 1.3.2. Cyanoacrylate form 6 1.4. Cyanoacrylate adhesive in oro-maxillofacial surgery 11 1.5. Treatment of gingival recession 12 1.6. Motivation and purpose 16 Chapter 2 Materials and Methods 17 2.1. Degradation and formaldehyde analysis 20 2.1.1. Weight loss 20 2.1.2. Formaldehyde analysis 20 2.2. Biocompatibility 21 2.2.1. Cells 21 2.2.2. Adhesive pellets and extraction solution preparation 22 2.2.3. Cell culture 23 2.2.4. WST-1 assay 23 2.3. Early bond strength test 24 2.3.1. Sample preparation 24 2.3.2. Initial bond strength test 27 2.3.3. 24-hrs bond strength 28 2.3.4. Failure pattern analysis 29 2.4. Degradation of bonding 29 2.4.1. Interfacial observation by optical coherence tomography 30 2.4.2. Bond strength after degradation 31 2.4.3. Failure pattern 31 Chapter 3 Results 32 3.1. Degradation and formaldehyde analysis 32 3.1.1. Weight loss 32 3.1.2. Formaldehyde release of cyanoacrylate adhesives 35 3.2. Biocompatibility 38 3.2.1. Cell Morphology Observation 38 3.2.2. Cell Viability 41 3.2.3. Cell Proliferation 43 3.3. Early bond strength test 44 3.3.1. Initial bond strength test 44 3.3.2. 24-hour bond strength test 45 3.3.3. Failure pattern 46 3.4. Degradation of bonding 48 3.4.1. Interfacial bond degradation 48 3.4.2. Bond strength after 14 days 48 3.4.3. Failure pattern of 14-day bond strength test 49 3.5. Bond strength over time 50 Chapter 4 Discussion 52 4.1. Degradation and formaldehyde analysis 52 4.1.1. Degradation of cyanoacrylate adhesives 52 4.1.2. Formaldehyde release of cyanoacrylate adhesive 53 4.2. Biocompatibility 54 4.3. Bond strength test 56 4.4. Failure pattern analysis 60 4.5. Degradation of bonding 60 4.5.1. Bonding interfacial degradation rate 60 Chapter 5 Conclusion 61 References 63

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