為了降低骨科手術後之感染風險，本研究針對具有良好生物相容性及骨傳導性之鈣基骨泥，添加A鹽作為抗菌因子，以N水溶液作為硬化劑，探討不同D的添加量、不同H之粒徑、硬化劑濃度及液粉比，對工作時間、硬化時間及崩解性之影響，確認以上性質無虞後，以最佳參數進行物化性質、機械性質測試，期望能得到具有良好之崩解性、注射性之抗菌型骨缺陷修復材料，達到降低手術感染風險與骨損傷修復之雙重目標。
實驗結果顯示添加D能夠降低抗菌型鈣基骨泥之崩解性；降低液粉比能夠縮短抗菌型鈣基骨泥之工作時間及硬化時間；改變硬化劑濃度對抗菌型鈣基骨泥之工作時間及硬化時間沒有顯著影響；抗菌型鈣基骨泥在人工體液浸泡一天內能夠於骨泥周圍提供鹼性環境。

SUMMARY
Calcium-based bone cement are widely used in dental and orthopedic application due to its superior biocompatibility, osteoconductivity, ability to be injected into bone defects. To decrease the risks of infection in clinical surgery, CMRT Lab developed antibacterial calcium-based bone cement with addition of A salt, using N solution as setting solution. The objective of this study was to investigate in vitro properties with different composition of antibacterial calcium-based bone cement, the concentration of setting solution, liquid to powder ratio and particle size. The in vitro properties including property of dispersion, working/setting time, mechanical strength, pH value. The higher D addition and higher liquid to powder ratio caused better performance in dispersion. The smaller size of H powder caused shorter working time and setting time. The pH value increased with immersion time in the first day. As to the dissolve of A salt, the antibacterial calcium-based bone cement present basic environment as immersion in simulated body liquid, it could prevent bacterial adhesion on first day.
Key words: Calcium based cement, antibacterial

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