| 研究生: |
許成彬 Xu, Cheng-Bin |
|---|---|
| 論文名稱: |
使用改良式ICP追蹤技術開發應用於肝臟切除手術之MR訓練系統 Development of a MR Training System for Liver Resection Surgery Using Modified ICP Tracking Technology |
| 指導教授: |
杜翌群
Du, Yi-Chun |
| 學位類別: |
碩士 Master |
| 系所名稱: |
工學院 - 生物醫學工程學系 Department of BioMedical Engineering |
| 論文出版年: | 2022 |
| 畢業學年度: | 110 |
| 語文別: | 英文 |
| 論文頁數: | 66 |
| 中文關鍵詞: | 肝臟切除手術 、混合實境 、彈性肝臟假體 、改良式ICP演算法 、MR訓練系統 |
| 外文關鍵詞: | liver resection, mixed reality, elastic liver phantom, modified ICP algorithm, MR training system |
| 相關次數: | 點閱:71 下載:0 |
| 分享至: |
| 查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報 |
肝癌的發病率和死亡率會隨著年齡的增長而增加,這在現今人口快速高齡化的趨勢中,肝癌相關醫療照護成為了急需面對的問題。肝臟切除手術為肝癌的主要治療方式,然而由於肝臟內部的血管結構複雜,臨床術前和術中規劃又僅能依靠CT影像,其因缺乏3D空間資訊,使得肝臟切除手術的成功與否相當仰賴醫師自身的經驗。有鑑於此,本研究提出一套使用改良式ICP追蹤技術開發應用於肝臟切除手術之MR訓練系統,系統可以區分為兩大部分。第一個部分是彈性肝臟假體的製作,提供臨床醫師在手術訓練時能有更真實的觸覺感受。在肝臟硬度值量測實驗中,本研究所製作的彈性肝臟假體平均硬度為18.8 DU,符合先前文獻所表明的肝癌患者的肝臟硬度範圍。第二個部分是利用改良式ICP追蹤技術將3D虛擬血管模型疊加至彈性肝臟假體上,且經由實驗結果顯示,在不同角度偏差情況下,本研究所提出的改良式ICP演算法對位誤差皆 <4 mm。希望藉由本研究所提出應用於肝臟切除手術之MR訓練系統,可以改善臨床醫師培訓成效,也可以作為未來其他應用之參考。
In the current trend of a rapidly aging population, medical care in relation to liver cancer has become an urgent issue. Liver resection is the main treatment method for liver cancer, and the internal anatomical structure of blood vessels is quite complex. In the preoperative and intraoperative planning, however, surgeons only can rely on CT images which lack of 3D spatial information, the success or failure of an operation depends on their own clinical experience. Therefore, this study proposed a development of a MR training system for liver resection surgery using modified ICP tracking technology, and it can be divided into two parts. The first part of this system introduced the fabrication of an elastic liver phantom that could provide clinicians with a realistic tactile sensation. In the measurement experiment on hardness of elastic liver phantom, the average hardness in this study was 18.8 DU, which is consistent with the liver hardness range of liver cancer patients from previous literature. In the second part, the 3D virtual vascular model was superimposed on the elastic liver phantom using a modified ICP tracking technology. The experiment result showed that the registration error with different angular deviations of the proposed modified ICP algorithm in this study was <4 mm. It is expected that the MR training system for liver resection surgery using modified ICP tracking technology can enhance the overall clinicians training effect and serve as a reference for other applications in the future.
[1] Anwanwan, D., Singh, S. K., Singh, S., Saikam, V., & Singh, R. (2020). Challenges in liver cancer and possible treatment approaches. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1873(1), 188314.
[2] Sayiner, M., Golabi, P., & Younossi, Z. M. (2019). Disease burden of hepatocellular carcinoma: a global perspective. Digestive diseases and sciences, 64(4), 910-917.
[3] Orcutt, S. T., & Anaya, D. A. (2018). Liver resection and surgical strategies for management of primary liver cancer. Cancer Control, 25(1), 1073274817744621.
[4] Kow, A. W. C. (2019). Transplantation versus liver resection in patients with hepatocellular carcinoma. Translational gastroenterology and hepatology, 4.
[5] Fang, C., Zhang, P., & Qi, X. (2019). Digital and intelligent liver surgery in the new era: Prospects and dilemmas. EBioMedicine, 41, 693-701.
[6] Huber, T., Huettl, F., Tripke, V., Baumgart, J., & Lang, H. (2021). Experiences with three-dimensional printing in complex liver surgery. Annals of Surgery, 273(1), e26-e27.
[7] Iwai, M., Kojima, T., Suriawinata, A.A. (2019). Anatomy and Function. In: Hashimoto, E., Kwo, P., Suriawinata, A., Tsui, W., Iwai, M. (eds) Diagnosis of Liver Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-6806-6_1
[8] Yang, L. L. (2021). Anatomy and Physiology of the Liver. In Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation (pp. 15-40). Springer, Cham.
[9] Ayyildiz, M. (2015). Effect of Preservation Solution and Period on the Mechanical and Histological Properties of Liver (Doctoral dissertation, Koç University).
[10] Cenveo - Drawing Liver Anatomy and Vascularisation - English Labels. (n.d.). AnatomyTOOL. (n.d.). Retrieved August 7, 2022, from https://anatomytool.org/content/cenveo-drawing-liver-anatomy-and-vascularisation-english-labels
[11] Hu, J., Huang, J., Liu, X., Zuo, Z. (2019). Clinical Anatomy of the Liver. In: Huang, J., Liu, X., Hu, J. (eds) Atlas of Anatomic Hepatic Resection for Hepatocellular Carcinoma . Springer, Singapore.
[12] Kwon, J.K. et al. (2021). Liver. In: Paltiel, H.J., Lee, E.Y. (eds) Pediatric Ultrasound. Springer, Cham. https://doi.org/10.1007/978-3-030-56802-3_11
[13] Kalra, A., Yetiskul, E., Wehrle, C. J., & Tuma, F. (2018). Physiology, liver.
[14] Underhill, G. H., & Khetani, S. R. (2019). Emerging trends in modeling human liver disease in vitro. APL bioengineering, 3(4), 040902.
[15] Alamri, Z. Z. (2018). The role of liver in metabolism: an updated review with physiological emphasis.
[16] Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 71(3), 209-249.
[17] Liver, International Agency for Research on Cancer. World Health Organization. Cancer Today. (n.d.). Retrieved August 7, 2022, from https://gco.iarc.fr/today/data/%20factsheets/cancers/11-Liver-fact-sheet.pdf
[18] Yang, J., Pan, G., Guan, L., Liu, Z., Wu, Y., Liu, Z., ... & Ouyang, G. (2022). The burden of primary liver cancer caused by specific etiologies from 1990 to 2019 at the global, regional, and national levels. Cancer Medicine.
[19] Reig, M., Forner, A., Rimola, J., Ferrer-Fàbrega, J., Burrel, M., Garcia-Criado, Á., ... & Bruix, J. (2021). BCLC strategy for prognosis prediction and treatment recommendation Barcelona Clinic Liver Cancer (BCLC) staging system. The 2022 update. Journal of hepatology.
[20] Musa, M. S., Ozsahin, D. U., & Ozsahin, I. (2019, March). A comparison for liver cancer treatment alternatives. In 2019 Advances in Science and Engineering Technology International Conferences (ASET) (pp. 1-4). IEEE.
[21] Orcutt, S. T., & Anaya, D. A. (2018). Liver resection and surgical strategies for management of primary liver cancer. Cancer Control, 25(1), 1073274817744621.
[22] Alirr, O. I., & Rahni, A. A. A. (2020). Survey on liver tumour resection planning system: steps, techniques, and parameters. Journal of Digital Imaging, 33(2), 304-323.
[23] McMillan, K., Flood, K., & Glaeser, R. (2017). Virtual reality, augmented reality, mixed reality, and the marine conservation movement. Aquatic Conservation: Marine and Freshwater Ecosystems, 27, 162-168.
[24] Tremosa, L. (n.d.). Beyond AR vs. VR: What Is the Difference between AR vs. MR vs. VR vs. XR? Retrieved August 7, 2022, from https://www.interaction-design.org/literature/article/beyond-ar-vs-vr-what-is-the-difference-between-ar-vs-mr-vs-vr-vs-xr
[25] VIVE 台灣. (n.d.). Retrieved August 7, 2022, from https://www.vive.com/tw/
[26] Jorjin Technologies Inc. (n.d.). Retrieved August 7, 2022, from https://www.jorjin.com/
[27] HoloLens 2. Microsoft. (n.d.). Retrieved August 7, 2022, from https://www.microsoft.com/en-us/hololens/buy
[28] Bothwell, B. (2022, January 26). Science & Tech Spotlight: Extended Reality Technologies. Retrieved August 7, 2022, from https://www.gao.gov/products/gao-22-105541
[29] Barel, A. (2017, August 8). The Differences between VR, AR & MR. Retrieved August 7, 2022, from https://medium.com/startux-net/the-differences-between-vr-ar-mr-27012ea1c5
[30] Extended Reality Market Size and Share Analysis, 2030. P&S Intelligence. (2020, September). Retrieved August 7, 2022, from https://www.psmarketresearch.com/market-analysis/extended-reality-xr-market-insights
[31] Gerup, J., Soerensen, C. B., & Dieckmann, P. (2020). Augmented reality and mixed reality for healthcare education beyond surgery: an integrative review. International journal of medical education, 11, 1.
[32] Kumar, R. P., Pelanis, E., Bugge, R., Brun, H., Palomar, R., Aghayan, D. L., ... & Elle, O. J. (2020). Use of mixed reality for surgery planning: Assessment and development workflow. Journal of Biomedical Informatics, 112, 100077.
[33] Hu, H. Z., Feng, X. B., Shao, Z. W., Xie, M., Xu, S., Wu, X. H., & Ye, Z. W. (2019). Application and prospect of mixed reality technology in medical field. Current medical science, 39(1), 1-6.
[34] Sadeghi, A. H., El Mathari, S., Abjigitova, D., Maat, A. P., Taverne, Y. J., Bogers, A. J., & Mahtab, E. A. (2020). Current and future applications of virtual, augmented, and mixed reality in cardiothoracic surgery. The Annals of Thoracic Surgery.
[35] Pelanis, E., Kumar, R. P., Aghayan, D. L., Palomar, R., Fretland, Å. A., Brun, H., ... & Edwin, B. (2020). Use of mixed reality for improved spatial understanding of liver anatomy. Minimally Invasive Therapy & Allied Technologies, 29(3), 154-160.
[36] 國立成功大學醫學院附設醫院 外科專科醫師訓練計畫書. (n.d.). Retrieved August 7, 2022, from https://surgery.ncku.edu.tw/var/file/126/1126/img/2165/177014666.pdf
[37] Liver Transplantation. Medical Travel World Wide Web. (n.d.). Retrieved August 7, 2022, from https://www.medicaltravel.org.tw/Feature.aspx?a=26&l=2
[38] 住院醫師教育課程. (n.d.). Retrieved August 7, 2022, from https://surgery.ncku.edu.tw/p/412-1126-15287.php?Lang=zh-tw
[39] Sanyal, S., Kron, P., Wylie, N., Hildalgo, E., Toogood, G. J., & Lodge, P. (2020). Outcomes of liver resection for hepatocellular carcinoma in octogenarians. HPB, 22(9), 1324-1329.
[40] Sauer, I. M., Queisner, M., Tang, P., Moosburner, S., Hoepfner, O., Horner, R., ... & Pratschke, J. (2017). Mixed reality in visceral surgery: development of a suitable workflow and evaluation of intraoperative use-cases. Annals of surgery, 266(5), 706-712.
[41] Pratt, P., Ives, M., Lawton, G., Simmons, J., Radev, N., Spyropoulou, L., & Amiras, D. (2018). Through the HoloLens™ looking glass: augmented reality for extremity reconstruction surgery using 3D vascular models with perforating vessels. European radiology experimental, 2(1), 1-7.
[42] Zhou, Z., Yang, Z., Jiang, S., Zhang, F., & Yan, H. (2019). Design and validation of a surgical navigation system for brachytherapy based on mixed reality. Medical physics, 46(8), 3709-3718.
[43] Wu, M. L., Chien, J. C., Wu, C. T., & Lee, J. D. (2018). An augmented reality system using improved-iterative closest point algorithm for on-patient medical image visualization. Sensors, 18(8), 2505.
[44] Estermann, S. J., Pahr, D. H., & Reisinger, A. (2020). Quantifying tactile properties of liver tissue, silicone elastomers, and a 3D printed polymer for manufacturing realistic organ models. Journal of the Mechanical Behavior of Biomedical Materials, 104, 103630.
[45] Yoon, Y. C., Lee, J. S., Park, S. U., Kwon, J. H., Hong, T. H., & Kim, D. G. (2017). Quantitative assessment of liver fibrosis using shore durometer. Annals of surgical treatment and research, 93(6), 300-304.
[46] de Jong, T. L., Pluymen, L. H., van Gerwen, D. J., Kleinrensink, G. J., Dankelman, J., & van den Dobbelsteen, J. J. (2017). PVA matches human liver in needle-tissue interaction. Journal of the mechanical behavior of biomedical materials, 69, 223-228.
[47] Nanashima, A., Tanoue, Y., Sakae, T., Tsuneyoshi, I., Hiyoshi, M., Imamura, N., ... & Nakamura, K. (2021). Relationship between hepatic venous anatomy and hepatic venous blood loss during hepatectomy. Surgery Today, 51(12), 1953-1968.
[48] Tang, S. kai. (n.d.). Start gesture - Mixed Reality | Microsoft Docs. Retrieved August 7, 2022, from https://docs.microsoft.com/en-us/windows/mixed-reality/design/system-gesture
[49] Meekhof, C. (n.d.). Point and commit with hands - Mixed Reality | Microsoft Docs. Retrieved August 7, 2022, from https://docs.microsoft.com/en-us/windows/mixed-reality/design/point-and-commit
[50] Model DD-5 Digital Durometer. Rex Gauge Durometers. (n.d.). Retrieved August 7, 2022, from https://www.durometer.com/product/model-dd-5-digital-durometer/
[51] Fundamental Concepts | Google VR | Google Developers. Google VR. (n.d.). Retrieved August 7, 2022, from https://developers.google.com/vr/discover/fundamentals
[52] Edwards, P. J., Chand, M., Birlo, M., & Stoyanov, D. (2021). The challenge of augmented reality in surgery. Digital Surgery, 121-135.
[53] Nopper, H., Schendel, O., Karayagiz, F., Freitas, U., Lück, T., Stadie, T., ... & Weyhe, D. (2021). Advanced training scenarios for liver surgery with realistic interactive 3D-printed phantoms. Transactions on Additive Manufacturing Meets Medicine, 3(1), 502-502.
[54] Keller, S., Tschan, F., Semmer, N. K., Holzer, E., Candinas, D., Brink, M., & Beldi, G. (2018). Noise in the operating room distracts members of the surgical team. An observational study. World journal of surgery, 42(12), 3880-3887.