光學同調性斷層攝影術是近年來利用低同調干涉術所發展相當快速的一種非侵入式光學造影方法。其造影的方式為利用同調光子閘截技術來取得具有影像資訊的光子。近年來，此技術藉由其量測光程差的能力，以此用來做為量測樣品折射率和厚度的有用工具。

　　本實驗將針對一般光學斷層掃描術的架構加以改良，除了以光纖式的結構降低外界環境的干擾之外，同時結合一商業化之自動對焦裝置與光纖式光學同調性斷層攝影術以降低因樣本或是樣本平台的輕微震動造成的量測誤差，並以同時量測單層樣本的折射係數與厚度。最後以自製的樣本來測試本系統的可行性。

　　最後，提出一種新式的偏振式光學同調斷層掃描術，並利用基因演算法來有高準確的量測出待測物之雙折變與光軸方向之特性。最後以模擬數據來測試本系統的可行性。

　Optical coherence tomography (OCT) is an optical imaging technique that allows high-resolution noninvasive cross-sectional imaging of tissue microstructure. Recently, there have been reports of the measurement of refractive index n and thickness t by the use of OCT combined with confocal optics.

　In this study, we develop a new optical fiber type of OCT with a commercial auto-focus device to simultaneously measure refractive index and thickness of a single-layer for demonstration. An auto-focus device is implemented to diminish the measurement error resulting from the slight vibration of the sample or sample stage. As compared to the conventional one, the new OCT setup is easily immune to the vibration effects. The system is demonstrated by two home-made samples.

　In the end, we present a new polarization-sensitive OCT (PS-OCT), and make use of genetic algorithm to measure the optical axis, birefringence of the sample precisely. The system is demonstrated by simulation.

Abramowitz, M. and Stegum, I.A., Handbook of mathematical function, Washington DC:Nat. But. Standards., 1963.
Beaurepaire, E., Boccara, A.C., Lebec, M., Blanchot, L. and Saint-Jalmes, H., “Full-field optical coherence tomography,” Opt. Lett., vol. 23, pp. 244-246, 1998.
Bouma, B.E. and Tearney, G.J., Handbook of optical coherence tomography, Marcel Dekker, Inc., 2002
Brigham, E.O., The fast fourier transform and its applications, Prentice Hall., 1988.
Cheong et al., “A review of optical properties of biological tissues,” IEEE Journal of Quantum Electronics, vol. 26, pp. 2166-2184, 1990.
Chinn, S.R. and Swanson, E.A., “Blindness limitation in optical coherence domain reflectometry,” Elec. Lett., vol. 29, pp. 2025-2027, 1993.
Cohen, D.K., Gee, W.H., Ludeke M., and Lewkowicz, J., “Auto-focus control: the astigmatic lens approach,” Applied Optics, vol. 23, pp. 565-570, 1984.
Dave, D.P., Akkin, T., and Milner. T.E., “Polarization-maintaining fiber-based optical low-coherence reflectometer for characterization and ranging of birefirngence,” Opt. Lett., vol. 28, pp. 1775-1777, 2003.
de Boer J.F., Milner, T.E., van Gemert M.J.C., and Nelson, J.S., “Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography,” Opt. Lett., vol. 22, pp. 934-936, 1997.
Fukano, T. and Yamaguchi, I., “Simultaneous measurement of thickness and refractive indices of multiple layers by a low coherence confocal microscope,” Opt. Lett., vol. 21, pp. 1942-1944, 1996.
Goodman, J.W., Statistical optics, New York, NY: John Wiley and Sons: 1985.
Groot, P.D., “Chromatic dispersion effects in coherent absolute ranging,” Opt. Lett., vol. 17, pp. 898-900, 1992.
Hartl, I., Li, X.D., Chudoba, C., Ghanta, R.K., Ko, T.H., Fujimoto, J.G., Ranka, J.K. and Windleler, R.S., “Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber,” Opt. Lett., vol. 26, pp. 608-610, 2001.
Haruna, M., Ohmi, M., Mitsuyama, T., Tajiri, H., Maruyama, H., and Hashimoto, M., "Simultaneous measurement of the phase and group indices and thickness of transparent plates by low-coherence interferometry", Opt. Lett., vol. 23, pp. 966-968, 1998.
Hecht, Eugene., Optics, Addison Wesley, third edition, 1998.

Hee, M.R., Huang, D., Swanson, E.A., and Fujimoto, J.G., “Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging,” J. Opt. Soc. Am. B., vol. 9, pp. 903-908, 1992.
Hee, M.R., Izatt, J.A., Swanson, E.A., Huang, D., Schuman, J.S., Lin, C.P., Puliafito, C.A., and Fujimoto, J.G., “Optical coherence tomography for ophthalmic imaging,” IEEE Eng. Med. Bio., pp. 67-76, 1995.
Hitzenberger, C., Goetzinger, E., Sticker, M., Pircher, M., and Fercher, A., “Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography,” Optics Express. vol. 9, pp. 780-790, 2001.
Hoeling, B.M., Fernandez, A.D., Haskell, R.C., Huang, E., Myers, W.R., Petersen, D.C., Ungersma, S.E., Wan, G., and Williams, M.E., “An optical coherence microscope for 3-dimensional imaging in developmental biology,” Optics Express. vol. 6, pp. 136-146, 2000.
Huang, D., Swanson, E.A., Lin, C.P., Schuman, J.S., Stinson, W.G., Chang, W., Hee, M.R., Flotte, T., Gregory, K., Puliafito, C.A., and Fujimoto, J.G. “Optical coherence tomography,” Science, vol. 254, pp. 1178–1181, 1991.
Izatt, J.A., Hee, M.R., Owen, G.M., Swanson, E.A., and Fujimoto, J. G.,“Optical coherence microscopy in scattering media,” Opt. Lett., vol. 19, pp. 590–592, 1994.
Izatt, J.A., Kulkarni, M.D., Wang, H.W., Kobayashi, K., and Sivak, M. V.,“Optical coherence tomography and microscopy in gastrointestinal tissues,”IEEE J. Select. Topics Quantum Electron., vol. 2, pp. 1017–1028, 1996.
Jonathan E.R., Jennifer A.K., Siavash Y., Andrew M.R. and Josegp A.I., “Simplitied method for polarization-sensitive optical coherence tomography ,” Opt. Lett., vol. 26, pp. 1069–1071, 2001.
Kam, Z., Agard, D.A., and Sedat, J.W., “Three-dimensional microscopy in thick biological samples: A fresh approach for adjusting focus and correcting spherical aberration,” Bioimaging, vol. 5, pp. 40-49, 1997.
Kwong, K.F., Yankelevich, D., Chu, K.C., Heritage, J.P., and Dienes, A., “400-Hz mechanical scanning optical delay ilne,” Opt. Lett., vol. 18, pp.558-560, 1993.
Lo, Y.L., Kuo, C.I., Chuang, C.H., and Yan, Z.Z., “Optical coherence tomography system with no high-precision scanning stage and Sstage controller,” Applied Optics, vol. 43, pp. 4142-4149, 2004.
Lu, C.W., “Study of optical doppler Ccoherence tomography,” National Taiwan University Master Thesis, 2001.
Maruyama, H., Inoue, S., Mitsuyama, T., Ohmi, M., and Haruna, M., “Low-coherence interferometer system for the simultaneous measurement of refractive index and thickness,” Appl. Opt., vol. 41, pp. 1315–1322, 2002.
Nishi, H., Itadani, T., Ohmi, M., and Haruna, M., “Tomography-based measurement of refractive index and thickness profiles by the low coherence interferometry,” 16th Int’l Conf. Opt. Fiber Sensors (OFS-16), pp. 764-767, 2003.
Ohmi, M., ohnishi, Y., Yoden, K., and Haruna, M., “In vitro simultaneous measurement of refractive index and thickness of biological tissue by the low coherence interferometry,” IEEE Trans. Biomed. Eng., vol. 47, pp. 1266–1270, 2000.
Pedrotti, F.L. and Pedrotti, L.S., Introduction to Optics, Prentice-Hall., 1996.
Profio, A.E. and Doiron, D.R.. “ Transport of light in tissue in photodynamic therapy of cancer,” Photochemistry and Photobiology, vol. 46, pp. 591-599, 1987.
Rollins, A.E. and Izatt, J.A., “Optimal interferometer designs for optical coherence tomography,” Opt. Lett., vol. 21, pp. 1484-1486, 1999.
Roth J.E., Kozak J.A., Yazdanfar S., Rollins. A.M., and Izatt, J.A., “Simplified method for polarization-sensitive optical coherence tomography,” Opt. Lett., vol. 26, pp. 1069-1071, 2001.
Schmitt, J.M., “Optical coherence tomography (OCT) : A Review,” IEEE J. Select. Topics Quantum Electron., vol. 5, pp. 1205–1215, 1999.
Swanson, E.A., Huang, D., Hee, M.R., Fujimoto, J.G., Lin, C.P., and Puliafito, C.A., “High-speed optical coherence domain reflectometry,” Opt. Lett., vol. 17, pp. 151-153, 1992.
Takada, K., Yokohama, I., Chida, K., and Noda, J., “New measurement system for fault location in optical waveguide devices based on an interferometric technique,” Appl. Opt., vol. 26, pp. 1603–1606, 1987.
Tearney, G.J., Bouma, B.E., and Fujimoto, J.G., “High-speed phase- and group-delay scanning with a grating-based phase control delay line,” Opt. Lett., vol. 22, pp. 1811-1813, 1997.
Tearney, G.J., Bouma, B.E., Boppart, S.A., Golubovic, B.E., Swanson, A., and Fujimoto, J.G., “Rapid acquisition of in vivo biological images by use of optical coherence tomography,” Opt. Lett., vol. 21, pp.1408-1410, 1996.
Tearney, G.J., Brezinski, M.E., Southern, J.F., Bouma, B.E., Hee, M.R., and Fujimoto, J.G., “Determination of the refractive index of highly scattering human tissue by optical coherence tomography,” Opt. Lett., vol. 20, pp. 2258–2261, 1995.
Vabre, L., Dubois, A., and Boccara, A.C., “Thermal-light full-field optical coherence tomography,” Opt. Lett., vol. 27, pp. 530-532, 2002.
Yoden, K., Ohmi, M., Ohnishi, Y., Kunizawa, N., and Haruna, M., “An approach to optical reflection tomography along the geometrical thickness,” Opt. Rev., vol. 7, pp.402-405, 2000.
Youngquist, R., Carr, C.S., and Davies, D.E.N., “Optical coherence domain reflectometry: A new optical evaluation technique,” Opt. Lett., vol. 12, pp. 158-160, 1987.
李冠卿, 近代光學, 聯經出版事業有限公司, 1988.