近年來伴隨著奈米科技的發展，磁性奈米材料廣泛的應用於生物醫學技術上。由於其獨特的超順磁特性，在外加磁場下，可以作為體內傳遞藥物的載體，並配合熱治療 (hyperthermia) 的技術，能夠有效抑制癌細胞，在醫學上相當具有研究價值。
本研究利用共沉澱法製備出磁性奈米粒子，在其外層包覆上β-環狀糊精，探討磁性奈米粒子的熱效應；最後利用環糊精中間疏水性的孔洞結構來包覆抗癌藥並探討其釋放行為。本研究以XRD來鑑定製備的Fe3O4與Fe3O4@β-CD粒子之晶相並估算其平均微晶尺寸，分別為8.18 nm與7.91 nm。在磁性分析上，從磁滯曲線可以得知Fe3O4與Fe3O4@β-CD粒子的飽和磁化量分別為67.4 emu/g與62.07 emu/g。為了應用於生物體內，我們將Fe3O4與Fe3O4@β-CD粒子進行滅菌處理，探討滅菌之後對於晶相、磁性質、熱效應、TEM影像是否會產生改變。而包覆藥物的探討，選擇capsaicin作為對象，很多的報告指出capsaicin對於癌細胞有明顯的抑制效果，特別是前列腺癌細胞。在本研究中以各種不同的包覆條件來探討Fe3O4@β-CD包覆capsaicin藥物釋放的效果。

To use magnetic nanoparticles for anticancer treatment has attracted a lot of attentions because of their potential for hyperthermia anticancer treatment and drug carriers. In this study, cyclodextrin, known to be a good host for the inclusion of guest molecule was used to coat onto the magnetic nanospheres. The magnetic nanoparticles were synthesized by co-precipitation. The average size of the Fe3O4 nanoparticles was about 8.14 nm, which was observed and calculated by TEM. Upon the modification with β- cyclodextrin, the nanoparticles could achieve much better dispersion in solution. Modification of the nanospheres with cyclodextrin, the crystalline size nearly did not vary. The results from SQUID indicated the saturation magnetizations of the bare and cyclodextrin coated Fe3O4 nanoparticles were 67.40 and 62.07 emu/g, respectively. Therefore, both nanospheres gained almost similar magnetization intensity without significant hysteresis. In this work, the thermal effect obtained from bare magnetic nanospheres and the cyclodextrin modified nanospheres were compared. With bare nanoparticles, temperature could increase to 70 oC in 10 min and 80 oC in 20 min. With cyclodextrin modified nanospheres, 60 oC could be reached in 10 min. Particularly, once the nanospheres oriented into a necklace-like pattern, the thermal effect was superior to those without the circle. Consequently, the feasibility of both magnetic nanoparticles for hyperthermia treatment on cancer cells is confirmed.

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