我們利用聚賴氨酸 (PLL) 跟聚酪氨酸 (PLT) 透過逐層組裝法去合成金奈米粒子/中孔洞二氧化矽奈米管(gold NP/m-silica tube)，以及利用聚賴氨酸跟聚酪氨酸的團聯共聚氨酸(PLL-b-PLT)透過超分子組裝法合成軟性球殼結構。金奈米粒子/中孔洞二氧化矽奈米管的合成是利用兩種可犧牲性的模版(PLL/PLT 和聚碳酸膜)的方法所製成的。利用逐層組裝法將PLL和PLT 置於聚碳酸膜的孔洞中,而還原金奈米粒子及沉析二氧化矽的反應皆會呈現在PLL/PLT多層膜中。金奈米粒子的大小會隨著增加金前驅物的濃度而增大，而且還原兩天的結果呈現出比較小的金奈米粒子分布在網狀結構的二氧化矽之中。金奈米粒子/中孔洞二氧化矽奈米管的觸媒效果會隨著減少金奈米粒子的大小而有所增加，不論是再多的金含量也呈現類似的結果。隨著改變 PLL-b-PLT團聯共聚氨酸的分子量，所呈現的自組裝種類也隨之改變。由氫核磁共振圖譜 (1H NMR) 以及動態光散射儀 (DLS) 的結果，我們可以去推斷其自組裝的種類。Lys212-b-Tyr106團連共聚氨基酸在酸鹼值為7及12，95/5% 體積比，水/甲醇的水溶液中呈現出囊泡雙層結構且PLL是位於外層而PLT是位於內層。相較於Lys17-b-Tyr12團聯共聚氨酸，在酸鹼值為7及12，95/5% 體積比，水/甲醇的水溶液中呈現出具反轉特性的囊泡結構。

Here we report the use of layer-by-layer (LBL) assembled poly(L-lysine)/poly(L-tyrosine) (PLL/PLT) multilayer films on the cylindrical pores in the polycarbonate (PC) membranes as templates for synthesizing gold nanoparticle/mesoporous silica tubes (gold NP/m-silica tubes) and supramolecular assembly of poly(L-lysine)-b-poly(L-tyrosine) (PLL-b-PLT) diblock copolypeptides. Synthesis of gold nanoparticle/mesoporous silica tubes (gold NP/m-silica tubes) using dual sacrificial templates (e.g., PLL/PLT film and PC membrane) was demonstrated through LBL assembly of PLL/PLT on membrane pores, and subsequent to reducing gold precursor and precipitating silica in the polypeptide multilayer films. The size and distribution of gold NPs inside the silica network can be controlled by reducing condition such as concentration of gold precursor and reducing time. The size of the gold NPs increased with the increases of gold precursor concentration and the sample with two days reduction showed better distribution of gold NP in the silica network, comparing with those with different conditions. The as-prepared gold NP/m-silica tubes possessed catalytic properties toward the reduction of p-nitrophenol. The gold NP/m-silica tubes with smaller size of gold NPs showed better catalytic property than those with larger size of catalyst. The catalytic property is correlated with the amount of gold inside the gold/silica catalysts. The poly(L-lysine)-b-poly(L-tyrosine) with high and low molecular weight were found to form different types of self-assembled structures. The type of the self-assembled structures has been analyzed through the 1H NMR and dynamic light scattering. The Lys212-b-Tyr106 formed a vesicular structure with the PLL block outside the bilayer and the PLT block inside the bilayer at pH 7 and 12 in 95/5% v/v water/methanol solution. In contrast, Lys17-b-Tyr12 presented the well reversible vesicle structure at pH 7 and pH 12 in 95/5% water/methanol solution.

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