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研究生：	王則堯 Wang, Tse-Yao
論文名稱：	氧化物對磷酸鈣骨水泥的影響 N/A
指導教授：	朱建平 Ju, Chien-Ping 陳瑾惠 Chern Lin, Jiin-Huey
學位類別：	碩士 Master
系所名稱：	工學院 - 材料科學及工程學系 Department of Materials Science and Engineering
論文出版年：	2005
畢業學年度：	93
語文別：	中文
論文頁數：	101
中文關鍵詞：	添加氧化物、骨水泥、磷酸鈣
外文關鍵詞：	Calcium Phosphate, CPC, Metal Oxide
相關次數：	點閱：60 下載：1
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摘要
科技的進步，在帶來高品質的生活享受的同時，往往會帶來許多意外傷害，如外傷、撕裂傷甚至骨折等。因此在這類外科手術極度發展的同時，外科手術所使用的生醫材料的開發以及應用，成為現代醫學發展的重點之一。
鈣磷系骨水泥，也就是calcium phosphate cement ，簡稱CPC。CPC最主要就是由鈣離子Ca2+再輔以磷酸根PO43-所組成的。這類的水泥具有良好的生物相容性，而且在生醫上面的應用也非常的廣泛。
本實驗是以原本的鈣源磷酸鈣粉末以及磷源帶有PO43-溶液的CPC(calcium phosphate cement)水泥，並添加微量氧化物MO或是其他種類的氧化物作為改善鈣磷系骨水泥性質。
在帶有PO43-的磷酸銨濃度為3M﹙標準濃度﹚時，添加MO的CPC試片抗壓強度約為45MPa，無添加MO的CPC試片約為40MPa。少量添加MO對於使用3M含有PO43-溶液的CPC試片，抗壓強度有明顯的增加。在不同粉液比的測試中，加入MO的CPC試片對於濃度分別為3M、2M、1.5M的磷酸銨，抗壓強度沒有明顯的變化。對於添加及未添加MO之CPC浸泡於Hanks’ sol.天數的多寡，浸泡天數越多，強度越弱。在SEM的觀察中發現，CPC表面的morphology對於試片的抗壓強度沒有太大的影響與關聯。然而隨著磷酸銨溶液濃度的減少，添加少量的MO對於CPC試片的抗壓強度，則沒有顯著的強度提升。

總目錄
摘要.......................................................I
目錄.....................................................III
圖目錄...................................................VI
表目錄...................................................XII
第一章  理論基礎與回顧...................................01
1-1-1      前言...........................................01
1-1-2      生醫材料的簡介.................................01
1-1-2-1    非陶瓷類生醫材料...............................01
1-1-2-2   生醫陶瓷…......................................02
1-1-2-2-1可吸收性生醫陶瓷.................................03
1-1-2-2-2近惰性生醫陶瓷...................................04
1-1-2-2-3表面活性生醫陶瓷.................................05
1-1-2-3  生醫玻璃.........................................05
1-2-1鈣磷系骨水泥.........................................06
1-2-2   TTCP的性質.......................................08
1-2-2-1   TTCP的生成.....................................08
1-2-2-1-1  使用燒結法生成TTCP.............................08
1-2-2-1-2  冷卻速率對於TTCP生成的影響....................09
1-2-2-2  TTCP與DCPD/DCPA的反應.........................09
1-2-2-3  TTCP在水中與磷酸溶液中的反應....................11
1-2-2-4  Na2HPO4以及NaH2PO4對TTCP/DCPA的影響..........12
1-2-2-5  研磨時間對於TTCP的影響..........................12
1-2-3   氧化鎂﹙MgO﹚的性質...............................13
1-2-3-1  MgO的生成.......................................13
1-2-3-1-1  MgO的特性與製作...............................13
1-2-3-1-2  Sol-gel法製作MgO...............................14
1-2-3-2    MgO的結構.....................................14
1-2-3-3   Mg2+的錯合物....................................15
1-2-4    HA添加金屬氧化物﹙燒結法﹚......................16
1-2-5    CaSO4˙2H2O在磷酸溶液中添加金屬氧化物...........16
1-2-6    長時間浸泡在SBF﹙人工體液﹚對CPC的影響.........17
1-2-7    實驗目的.........................................18
第二章  實驗步驟與方法...................................34
2-1   實驗原料的準備......................................34
2-2   實驗流程............................................34
2-2-1  CPC的試片製作.....................................35
2-2-1-1  加入MO的實驗流程................................35
2-2-1-2  不同L/P且添加MO的CPC的製作....................36
2-2-1-3  浸泡於Hanks’ sol.天數的影響........................37
2-2-2   混有MO的CPC性質................................37
2-2-2-1  抗壓強度測試.....................................37
2-2-2-2  X光繞射分析﹙XRD﹚...............................38
2-2-2-3  EDS能譜儀分析...................................38
2-2-2-4  掃描式電子顯微鏡分析﹙SEM﹚......................39
2-2-2-5  FT-IR霍式紅外線光譜儀............................39
2-2-2-6  Working time與setting time的測試....................40
第三章  實驗結果與討論...................................52
3-1	不同磷酸銨濃度且添加MO的CPC之測試................52
3-1-1	抗壓強度結果........................................52
3-1-2	不同磷酸銨濃度的XRD分析...........................52
3-1-3	FT-IR紅外線光譜分析.................................53
3-2	使用不同L/P比﹙粉液比﹚對於對於添加MO的CPC的影響...59
3-2-1	不同L/P比對於抗壓強度的影響.........................59
3-2-2	不同L/P比的XRD分析................................60
3-2-3	不同磷酸銨濃度的SEM分析............................61
3-3	在人工體液放置長時間對於CPC的影響..................69
3-3-1	對於抗壓強度的影響..................................69
3-3-1-1	2M磷酸銨對於抗壓強度的影響.......................69
3-3-1-2	3M 磷酸銨對於抗壓強度的影響......................69
3-3-2 長時間浸泡之XRD分析...............................70
3-3-3  長時間浸泡之FT-IR分析..............................71
3-3-4 長時間浸泡之SEM分析...............................72
3-4  其他性質的探討.......................................84
3-4-1  使用3M磷酸銨的CPC的性質比較.....................84
3-4-2  使用2M 磷酸銨的CPC的性質比較.....................84
3-4-3  使用1.5M 磷酸銨的CPC的性質比較...................85
3-4-4  使用1M 磷酸銨的CPC的性質比較.....................86
第四章  結論.............................................89
參考文獻.................................................91
附錄.....................................................94
                                    

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校內：2010-07-27公開
校外：2015-07-27公開

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