本論文係有關兼具近紅外光光熱治療與光驅動藥物釋放功能之六硼化鑭(LaB6)奈米粒子與熱敏感型高分子之複合微粒的製備。首先利用珠磨分散技術得到粒徑約80 nm之LaB6奈米粒子，並以溶膠凝膠法在其表面被覆二氧化矽奈米殼層(LaB6@SiO2)以提升其水中分散性。接著3-(三甲氧基甲硅烷基)丙基丙烯酸酯(MPS)修飾，使其表面具有C=C官能基，再以自由基共聚合法分別與氮-異丙基丙烯醯胺(NIPAAm)及丙烯醯胺(AAm)或羥甲基丙烯酰胺(NHMA)單體合成表面被覆具熱敏感型NIPAAm/AAm共聚物(LaB6@SiO2@P-A)及NIPAAm/NHMA共聚物(LaB6@SiO2@P-N)之複合微粒。雖然熱敏感型高分子的被覆會稍微降低LaB6奈米粒子的近紅外光吸收，但所得複合微粒仍具有良好的近紅外光光熱轉換特性。此外，AAm或NHMA的添加雖然有助於將熱敏感型共聚物在水中之低臨界溶液溫度(LCST) 提升至高於人體正常體溫(37C)數度C，但在磷酸緩衝鹽中，其LCST則會低於37C，且複合微粒在溫度超過40C以上會有明顯凝聚的現象，導致無法應用於藥物釋放。未來有待進一步發展LCST高於人體正常體溫數度C且適用於磷酸緩衝鹽的熱敏感型高分子，以改進複合微粒之性能。

This thesis concerns the preparation of the composite microspheres composed of lanthanum hexaboride (LaB6) nanoparticles and thermosensitive polymers. They possessed the functions of near infrared (NIR) photothermal therapy and NIR-triggered drug release. At first, LaB6 nanoparticles with a mean diameter of 80 nm were obtained by a stirred bead milling process and then surface-coated by silica shells via a sol-gel route to improve the dispersion in aqueous solution. Next, their surface was modified with 3-(trimethoxysilyl)propyl methacrylate (MPS) to introduce the C=C groups and then further coated by the thermosensitive P(NIPAAm-co-AAm) and P(NIPAAm-co-NHMA) via the free radical co-polymerization of N-isopropylacrylamide (NIPAAm) and acrylamide (AAm) or N-(hydroxymethyl)acrylamide (NHMA) to yield the composite microspheres. Although the coating by the thermosensitive polymers lowered the NIR absorption of LaB6 nanoparticles slightly, the resulting composite microspheres still exhibited good NIR photothermal conversion property. In addition, the addition of AAm or NHMA could raise the lower critical solution temperatures (LCST) of thermosensitive copolymers in water to the temperatures which were several degrees centigrade higher than the normal human body temperature (37C). However, in phosphate buffer saline, their LCST values were lower than 37C and the aggregation of composite microspheres would occur significantly. This made them unsuitable for application in drug release. In the future, it was necessary to develop the thermosensitive polymer whose LCST was several degrees centigrade higher than the normal human body temperature and practicable in phosphate buffer saline in order to improve the performance of composite microspheres.

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