| 研究生: |
許書韋 Hsu, Shu-Wei |
|---|---|
| 論文名稱: |
蛋白質資料庫(PDB)中結構穩定的螺旋體序列之統計分析 Statistical Analysis for Stable Helical Sequence Segments in PDB |
| 指導教授: |
王清正
Wang, Ching-Cheng |
| 學位類別: |
碩士 Master |
| 系所名稱: |
電機資訊學院 - 製造工程研究所 Institute of Manufacturing Engineering |
| 論文出版年: | 2005 |
| 畢業學年度: | 93 |
| 語文別: | 中文 |
| 論文頁數: | 27 |
| 中文關鍵詞: | 蛋白質 、二級結構 、電腦協助 、資料庫 、預測 |
| 相關次數: | 點閱:56 下載:1 |
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蛋白質的三維結構決定其生理功能,然而決定立體結構的實驗曠日費時,故預測方法遂成為決定立體結構之重要輔助工具之ㄧ,蛋白質二級結構的預測通常被認爲是蛋白質立體結構預測的基礎,本研究將集中焦點於二級結構中的螺旋體序列。
現有二級結構之預測方法偏重於電腦運用的複雜演算法(基因演算法、類神經網路等),並且對所有的胺基酸序列片段預測判斷,因此易造成預測方法精準度不佳且可信度不高。鑑此,本研究利用現存螺旋體資料庫進一步分析,彙整出結構穩定螺旋體的patterns、建構胺基酸特性分類函式及整理一些螺旋體特性,期望能提供使用者作為輔助預測判斷之用。我們避免了運用複雜的運算過程而得到的結果,而是用結構穩定的螺旋體做為分析運用,目的是希望能以較簡單預測的螺旋體序列,減少預測分析時的複雜度。
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