目前世界上有上百萬個病患再忍受著糖尿病的折磨，且每當用餐過後都需要刺穿自己的手指取出血來量測血糖濃度以確認胰島素注射的時機，但這樣侵入式的血糖量測方式不但有著被細菌感染的風險更讓人痛苦的是一天要刺穿手指數次，這實在令人難以忍受。因此為了幫助病人脫離這樣的痛苦無創血糖量測技術也因運而生並如火如荼的發展著。此研究所使用的技術是將六道不同偏振狀態的偏振光以55度入射角射入裝在射應比色槽裡的待測溶液，當光進入溶液中經過複雜散射過後再由垂直擺設的史托克儀接收散射光。之後再將量測到的史托克向量計算成微分穆勒矩陣就能夠分解出並找到能夠隨著葡萄糖變化的光學參數(如:線性雙折射、圓性雙折射、線二色性、圓二色性與去偏極化性質)。就實驗得出，我們所熟知應該與葡萄糖正相關的光旋轉量在實驗中卻是隨機亂跳，反倒是去偏極化程度卻與葡萄糖濃度呈負相關，且光是用商業的史托克儀就能達到100mg/dL的靈敏度。因此若再使用靈敏度較高的設備與更精確能夠擬合出複雜散射光的程式將能大大提高其發展可能。因此史托克-穆勒偏光法是發展無創血糖系統相當具有潛力的一種方式。

Nowadays millions of people suffer from diabetes. They have to extract blood by piercing their finger after eating to measure the blood glucose concentration. The invasive way is not only unsafe but also accompanied by pain many times a day, so noninvasive glucose monitoring technique are rapid growth now. In this study, Stokes-Mueller polarimetry are used to analyze the depolarization states between glucose and tissue phantom. Six incident lights with different polarization states illuminate the liquid stored in quartz cuvette with 55° incident angle, and set the Stokes meter vertical to gather the output signal after the complicate scattering. Output Stokes vectors are used into the differential Mueller matrices and try to extract kinds of optical properties such as Linear birefringence(LB), circular birefringence(CB), Linear dichroism (LD), circular dichroism(CD) and Depolarization, then we can find out which parameter will change identically when the glucose is increased in the turbid media. According to the experiment, the optical rotation angle regarding to the glucose concentration was unexpectedly changed randomly, but the depolarization state was decreased when adding more glucose into the liquid and its sensitivity approached to 100mg/dL and this specification is close to the commercial Stokes meter. Thus, it has a great potential to develop noninvasive glucose monitoring system and diabetics would benefit greatly with this new device.

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