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研究生： 劉聯璁
Liu, Lian-Cong
論文名稱： 磷酸鈣+硫酸鈣複合材骨水泥性質研究
Investigation of properties of calcium phosphate+calcium sulfate composite cement
指導教授： 陳瑾惠
Chern Lin, Jiin-Huey
朱建平
Ju, Chien-Ping
學位類別： 碩士
Master
系所名稱： 工學院 - 材料科學及工程學系
Department of Materials Science and Engineering
論文出版年： 2009
畢業學年度： 97
語文別： 中文
論文頁數： 146
中文關鍵詞： 硫酸鈣 、磷酸鈣 、氫氧基磷灰石
外文關鍵詞： HA, calcium sulfate, calcium phosphate
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    • 中文摘要
    磷酸鈣骨水泥具有優良的生物相容性與適當的機械強度，且具骨傳導支持作用，但不具有骨增生作用，所以在生物體內吸收速率相當緩慢使得骨細胞不易取代；硫酸鈣也具有良好的生物相容性，在生物體內溶解速率快，而溶解的同時會釋放鈣離子，使得材料具有誘骨性，但缺點硫酸鈣植入材吸收速率太快，使得骨細胞來不及長入缺陷，使纖維組織先行生成，阻礙骨組織生長而影響新生骨的生成。因此磷酸鈣和硫酸鈣混合後，利用硫酸鈣快速被吸收當作製造骨基質原料及產生空洞效果的特性，有利於新骨長入。
    本實驗選用75+25複合材和65+35複合材二種骨水泥複合材在生物體外做短時間及長時間的機械性質及其他物理性質之分析與探討。
    整題而言，複合材骨水泥在未來具有相當大的發展性。

    Abstract
    Calcium phosphate has excellent biocompatibility and adequate mechanical properties but has slow resorption in the human body.
    Without osteoinductive property, It has also shown osteoconductive and sustaining characterization . Calcium sulfate has also excellent biocompatibility.It is a kind of materials that will not cause inflammation and has fast resorption in human body. When calcium sulfate dissolved, the calcium ion was released that makes calcium phosphate composite with osteoinductive property. calcium sulfate implants has resorption quickly in the human body. It makes the fiber structure production advance, causes bone tissue to grow affects the newborn production. The absorpted calcium sulfate will be used as materials of bone matrix. It will make porous effect in composite. The newly formed bone integrates into the implant along with the pore and contacts directly with crystals of calcium phosphate.
    The present work is a study of 75 +25composite and 65 +35 composite soaking Hanks’ solution with short time and long time of mechanism, mechanical property and physical property in vitro.
    Composite has good biocompatibility.The composite has great potential for use as implant material.

    目錄 封面…………………………………………………………… Ⅰ 授權書………………………………………………………… Ⅱ 簽名單………………………………………………………… Ⅲ 中文摘要 Ⅳ Abstract Ⅴ 致謝 Ⅵ 第一章　總序論 1 1-1生醫植入材料分類及發展簡介 1 1-1-1生醫材料的定義 1 1-1-2生醫材料的分類 2 1-1-2-1材料的性質分類 2 1-1-2-2材料來源的分類 5 1-1-2-3材料的替代對象分類 6 1-1-2-4按材料及其製品與人體接觸程度分類 6 1-1-3生醫材料發展簡史 7 1-2生醫陶瓷的種類 11 1-3人體硬組織成分及性質簡介 16 1-4生醫骨科人工植入材料所需具備的條件 21 1-4-1骨取代物在生物學上的要求： 21 1-4-2骨取代材料性質與製程的要求 21 第二章 簡介與文獻回顧 23 2-1 半水硫酸鈣簡介 23 2-1-1半水硫酸鈣的發展回顧 23 2-1-2 半水硫酸鈣的性質、結構及反應過程 26 2-1-3半水硫酸鈣骨水泥的優點及缺點 27 2-2 磷酸鈣簡介 31 2-2-1磷酸鈣系列骨水泥發展 31 2-2-2磷酸鈣的性質、結構及反應過程 32 2-2-3雙相磷酸鈣骨水泥 35 2-2-磷酸鈣骨水泥的優點及缺點 36 Ca(OH)2 38 2-3磷酸鈣系與半水硫酸鈣系形成之多相複合生醫材料 41 2-3-1 HA / CaSO4･ 1/2H2O composite 42 2-3-2 α-TCP / CaSO4･ 1/2H2O composite 44 2-3-3 α-TCP / CaSO4･ 2H2O composite 46 2-3-4 TTCP / DCPA/CaSO4･ 1/2H2O composite 48 2-4骨水泥植入生物體內(in vivo)近期文獻回顧 55 第三章 實驗原理及步驟 60 3-1 實驗使用藥品 60 3-2 機械性質實驗步驟與分析方法 60 3-2-1 磷酸鈣與半水硫酸鈣複合材粉末製備 60 3-2-2 抗壓試片製作與強度測試 60 3-2-3 工作與硬化時間測量 61 3-2-4 PH值的量測 61 3-2-5 X-Ray diffraction （XRD）分析 63 3-2-6 Scanning Electron Microscopy（SEM）表面觀察 64 3-2-7細胞毒性測試 65 第四章　結果與討論 72 4-1 以solution1為硬化劑對75+25複合材性質之結果與討論： 72 4-1-1 以solution1為硬化劑對75+25複合材之浸泡Hanks’ solution一天後機械性質測量: 72 4-1-2 75+25複合材工作及硬化時間測量結果 74 4-2 以不同比例磷酸鈣鹽 和半水硫酸鈣複合材添加solution1間之浸泡Hanks’ solution一天後機械性質測量： 78 4-2-1 增加複合材半水硫酸鈣重量百分比添加solution1浸泡Hanks’ solution一天後機械性質測量： 79 4-3 以solution1為硬化劑對65+35複合材及60+40複合材性質之結果與討論： 82 4-3-1 以solution1為硬化劑對65+35複合材之浸泡Hanks’ solution一天後機械性質測量: 82 4-3-2 以solution1為硬化劑對60+40複合材之浸泡Hanks’ solution一天後機械性質測量: 84 4-3-3 65+35複合材工作及硬化時間測量結果 85 4-4複合材初始反應情況： 90 4-4-1初期骨水泥的PH值變化： 90 4-4-2 骨水泥的注射性： 90 4-4-3複合材浸泡Hanks’ solution短時間抗壓強度分析 91 4-5複合材長時間浸泡Hanks’ solution之結果討論與分析： 98 4-5-1 長時間抗壓強度分析： 98 4-5-2 XRD分析： 101 4-5-3 SEM 微觀結構分析： 103 4-5-4 浸泡Hanks’ solution不同時間之PH值變化比較： 104 4-6 細胞毒性測試 117 結論…………………………………………………………120 參考文獻…………………………………………………… 122

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