末期腎臟病患者在進行血液透析治療時，需要一條血液通路提供足夠的血流量通過，此通路稱為動靜脈瘻管，而此通路使用一段時間後，可能致使病理變化發生，例如:血管內膜增生及血栓的形成，會使得動靜脈瘻管功能失效。動靜脈通路可以透過觸診感覺顫動與脈動、聽診器、血管超音波或血管造影來做阻塞情況評估。雖然超音波檢測是一種有效的非侵入式技術，對於動靜脈通路預測有著高度的準確性，但是此種技術需要依賴醫院儀器與專業技術人員的操作。因此，本研究希望發展一種血管血流監聽檢測法(Phonoangiography)，可以做到居家照護及方便、立即檢測的系統。動靜脈通路的發生阻塞情形對於血行動力參數與聲音訊號會有明顯的影響。因此，在這項實驗研究中建立了一套簡化人體複雜循環的雙迴路系統。根據阻塞程度的變化與固定音訊量測點做了一連串的分析，希望能在未來的居家與臨床的血管血流監聽檢測法系統找到決定性的參數與規則。經過一連串的實驗與驗證後，發現其血行動力參數包含病灶處壓力與流量相對於阻塞程度之斜率改變處為阻塞程度(degree of stenosis, DOS)在85 - 90 %區間，這可以解釋為何臨床上都會建議患者在洗腎瘻管達到此阻塞程度時進行手術修復瘻管功能。此外在血管血流監聽檢測法的部分，亦發現有類似的趨勢。隨著DOS的增加其音訊頻譜分析後的第三峰值及第三峰值能量積分值增加，到了DOS 85 %之後斜率明顯改變，結果顯示音頻方面的第三峰值分析方法的確可以用來進行評估瘻管阻塞情形的參考指標。

This study has developed a Phonoangiography method for using in a home-based care system to evaluating arteriovenous shunt (AVS) stenosis in hemodialysis patients. Phonoangiography is a noninvasive tool for auditing the local fluid motion in the narrowed arteries and the assessing arterial dysfunction. A bruit spectral analysis could be considered a valuable noninvasive method for quantifying the severity of vessel stenosis. A specific mock model has been set up to simplify the modeling of blood flow condition and to analyze the spectrum. It follows that a more precise relationship of phonography to stenotic lesions can be observed.

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