摘要

聚羥基丁酸酯(PHB) 為一對環境無害之天然性生物可分解(相容性)之材料。在醫藥及生物材料上有廣泛的應用性，具發展潛能可取代現今一些塑膠材料。

本研究所得纖維主要是利用氯仿及氯仿/N,N-二甲基甲醯胺共溶劑溶解PHB形成均勻溶液後以電紡絲法來製備，但因氯仿具揮發性，會造成不銹鋼針頭前端之Taylor cone乾涸形成膠狀物中斷電紡絲製程，因此可利用氮氣攜帶飽和氯仿蒸汽包覆Taylor cone的方式加以克服此難題。

本研究主要探討操作變數及溶液性質對電紡絲製程中圓椎高度、液柱長度、液柱直徑與纖維直徑變化的影響。

實驗發現溶液流量(Q)、操作電壓(V)及溶液黏度(η0)的改變對纖維直徑(df)及液柱直徑(dj)存在著一重要的scaling law關係分別為：dj~V^-0.56、df~V^-0.61, dj~Q^0.61、df~Q^0.33, dj~η0^0.04、df~η0^0.36。

在固定溶液性質時改變操作變數(Q與V)進行電紡絲所得纖維直徑及液柱直徑遵循以下關係：df~dj^0.54。

Abstract

Poly(3-hydroxybutyric acid) (PHB) is a natural biodegradable plastic with biocompatibility and without any toxic byproducts. It is used mainly in biomaterials for medical applications and has a high possibility to replace conventional non-biodegradable materials.

The PHB fibers were electrospun from PHB/CF or PHB/CF+DMF solutions. Since CF has a high volatility, the Taylor cone at the tip of the needle will become gel. We used N2 as a carrying gas for bringing the cone to overcome this problem.

In the study, we used PHB/CF+DMF solutions to discuss the effects of the processing variables and solution properties on the morphologies of cone height, jet length and jet/fiber diameters.

Some scaling laws between the jet diameter(dj), fiber diameter(df) and the flow rate(Q), applied voltage(V) and solution viscosity(η0) were derived and expressed as follows: dj~V^-0.56、df~V^-0.61, dj~Q^0.61、df~Q^0.33, dj~η0^0.04、df~η0^0.36.

Regardless of the processing variables, dj and df were found to follow a master curve: df~dj^0.54, at a given solution.

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