根據WHO的統計，胃癌在全球的癌症發生率及死亡率均在五名內，由此可知胃癌為一個不容小覷的癌症。胃癌有95%以上是腺癌，依照Lauren’s組織學分類可分為腸道型、瀰漫型及混合型，其中以腸道型的比例佔一半以上，胃黏膜腸上皮化生(intestinal metaplasia; IM)為腸道型的癌前病變，導致其病變的因素很多，尚無完全有效的治療方法，所以胃癌的早期檢測預防及治療方法至今仍為一大挑戰。微型核糖核酸(miRNA)，是一種單股且非編碼蛋白質的小片段RNA，近年來發現miRNA與繁多疾病息息相關。因此，本研究收集了患有IM的患者的組織和已康復患者的組織，透過高通量定序比較兩組間miRNA及基因表現的差異。本研究發現miR-200b-3p，miR-200c-3p，miR-10b-5p和miR-425-5p，在胃黏膜腸上皮化生組織中有異常表達的現象。利用PMA刺激胃癌細胞發炎來驗證miRNA在胃癌細胞中的表現，確定miR-425-5p的表現會增加，並確認其目標基因為BANP和RABAC1，這兩個基因在腸上皮化生組織中也有下調現象，此外抑制miR-425-5p的表達後，胃癌細胞生長及遷移會趨緩，並推測miR-425-5p可能會促進為癌發展。期望未來藉由檢測miR-425-5p的表達，嘗試開發成為一種早期診斷胃癌的非侵入式生物標記檢測平台。

Gastric cancer is the top five incidence and mortality rates of cancers in the worldwide. More than 95% of gastric cancer is adenocarcinoma, which is divided into intestinal, diffuse and mixed histotype according to Lauren's histological classification. Intestinal type is the major of gastric adenocarcinoma, which developed from the intestinal metaplasia (IM) of precancerous lesions. Many factors cause intestinal metaplasia and there is no completely effective method to reverse it. Therefore, the early detection and the prevention of gastric cancer is still a big challenge. In recent years, miRNAs are reported to be involved in many cancer progression. Therefore, this research collected the tissues from the patients who continually suffered from IM and IM-regression after H. pylori eradication. The differential expressed miRNAs and mRNAs were identified. It has found that miR-200b-3p, miR-200c-3p, miR-10b-5p and miR-425-5p are up-regulated in the intestinal metaplasia tissue, and discovered that they were also up-regulated under inflammatory stimulation in gastric cancer cells. It was determined that the target genes of miR-425-5p were BANP and RABAC1, which were also down-regulated in intestinal metaplasia. Besides, knockdown miR-425-5p attenuated proliferation and migration of gastric cancer cells. It suggested that miR-425-5p may promote the development of gastric cancer. In the future, this research can further verify the role of miR-425-5p in intestinal metaplasia by more clinical samples, and try to develop a non-invasive biomarker detection platform for early diagnosis for gastric cancer.

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