慢性神經壓迫 (CNC) 損傷是人類神經性疼痛和周圍神經功能障礙的常見原因。在以前的研究中，臨床檢查和電診斷研究仍然是診斷神經損傷的標準，但它們可能難以診斷患有糖尿病等伴隨疾病的患者的慢性神經壓迫損傷。在以往的研究中，缺血和壓迫可導致慢性神經損傷且在壓迫初期神經發炎情況下會有微血管網路出現在神經內側，因此一種可以可視化神經血管並計算血流速度的成像方法可能是評估早期慢性神經壓迫損傷的潛在指標。
本實驗中採用一種基於超音波顯影劑定位的技術的方式對慢性神經壓迫損傷的老鼠做分析用於確認神經中大血管的損傷情況與其作用，並將超音波定位顯微鏡技術引入實驗中，希望找到微血管結構變化在神經壓迫損傷中扮演的角色。實驗結果說明超音波定位顯微鏡技術可對神經內血流情況與微血管結構做追蹤與評估，因此可以得出結論，超音波定位顯微鏡可以評估早期慢性神經壓迫損傷。

Chronic nerve compression (CNC) injury is a common cause of neuropathic pain and peripheral nerve dysfunction in humans. Clinical examination and electrodiagnostic studies remain the gold standard for diagnosing nerve injury in previous studies. Still, it can be difficult to diagnose chronic nerve compression injury in patients with concomitant diseases such as diabetes. In previous studies, ischemia and compression lead to chronic nerve compression, so an imaging method that can visualize nerve vessels and calculate blood flow velocity may be a potential indicator for evaluating early chronic nerve compression injury.
In this experiment, the method based on an ultrasonic contrast agent was used to analyze the chronic nerve compression injury in rats to confirm the damage and function of the nerve and large blood vessels. Then the ultrasonic localization microscopy technology was introduced into the experiment, hoping to find the microvascular structure. Alter the effect of nerve compression injury. The experimental results show that the ultrasound localization microscopy technique can track and evaluate the nerve's blood flow and vascular structure. Therefore, it can be concluded that ultrasound localization microscopy can assess early chronic nerve compression. damage.

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