隨著經濟和技術的發展，個人保健用品 (Personal care products, PCPs)被廣泛添加於日常產品中，以增加其功能性。伴隨著民眾大量地使用，PCPs及其代謝物都可能進到民生污水處理廠，當這些污染物質無法有效被去除時，則會透過排放進到自然水體，因此有必要了解其在污水處理流程中之變化。
本研究採集臺灣四座民生污水處理廠各處理單元之出流水及廢棄污泥，使用報導基因酵母菌試驗法檢測樣本之內分泌干擾活性，並以液相層析串聯式質譜儀檢測常見之PCPs，包括防曬劑、防腐劑、抗菌劑及消毒劑在處理過程中的濃度變化。研究中亦將常見之三種防曬劑，2-羥基-4-甲氧基二苯甲酮、5-氯-2-羥基二苯甲酮及2,2'-二羥基-4-甲氧基二甲酮進行氯化，並進一步分析其衍生物之結構、內分泌干擾活性、與進、出流水中之濃度。
內分泌干擾活性試驗表明，二苯甲酮類物質大多具有抗雄激素活性、類(抗)雌激素活性、抗鹽皮質激素活性及抗孕激素活性，其氯化衍生物亦具有抗雄激素、抗雌激素、抗鹽皮質激素及抗孕激素活性。此外，在所有污水廠的放流水中仍然可測得抗鹽皮質激素活性，表示抗鹽皮質激素物質會進到環境水體中。
液相層析串聯式質譜儀分析結果顯示，各污水廠放流水中總二苯甲酮的濃度範圍為94 至 420 ng/L，其中以二苯甲酮及2,2'-二羥基-4,4'-二甲氧基二苯甲酮之濃度最高。此外，於第一季放流水中皆有測得2-羥基-4-甲氧基二苯甲酮之氯化衍生物，濃度範圍為0.85至3.63 ng/L。於各污水廠之進流水中，對羥基苯甲酸甲酯及對羥基苯甲酸丙酯之檢出頻率及濃度都較高，不過經污水處理後都可以有效之去除，去除效率介於87至98%間。污泥中測得較高濃度之三氯沙 (21至416 ng/g)、三氯卡班 (9至620 ng/g)及十二烷基二甲基苄基氯化銨 (167至6865 ng/g)。本研究中發現傳統污水廠無法有效去除部分的PCPs，未來有必要關注這類新興物質，並尋求更有效的污水處理方法。另外廢棄污泥中亦存在PCPs，若污泥有再利用之規劃，則有需要謹慎評估其對土壤環境及生物之影響。

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