本論文致力於探討利用有限元素分析軟體(ANSYS)調整相關參數以模擬微型磁力線圈之電磁場的分佈。建立的三維模型與相關實驗比較後證實，其結果的正確性可作為發展磁電式基因轉殖晶片的設計架構。
此模型結構主要採用環型線圈設計，討論重點在於以環型線圈半徑、環型線圈寬度，環型線圈的沉積厚度及線圈開口角度等條件改變使電流所感應產生微電磁場之變化；其目的是希望能操控接合有螢光基因的磁奈米粒子而產生局部濃縮的效果，再施加短暫電場以產生細胞膜的暫時性微小孔隙，使粒子藉通道進入細胞中以增加基因轉殖率。
在針對不同條件的設計下進行模擬後發現，所設計的微電磁場其磁場分佈主要取決於線圈半徑，並隨隔離層高度之改變，當線圈半徑越小時，可以得到較佳的電磁場分佈。而環型線圈寬度、線圈沉積厚度及線圈開口角度的變化則對電磁場影響不大。由此模擬的結果將有助於晶片設計以提高基因的轉殖率及區域性傳遞的效率。

This thesis mainly focuses on the use of Finite Element Method analysis tool, “ANSYS”, to adjust relative parameters in order to simulate the distribution of micro electromagnetic fields. The results of this 3D model matched to that resulted from related experiments. Therefore this study suggests that this could help to develop the design structure of electromagnetic gene chips.

The main structure of ANSYS model is a loop (or ring) type. The key factors discussed in this thesis are the radius of inner ring, the width of the ring, the thickness of the deposited film, the open angle of the ring, and so on. These parameters cause the variation of micro electromagnetic fields which are inducted by the current. The goal of this design is to use magnetic nano particles with fluorescent gene to control the effect of partial condensation meanwhile to apply a transient electrical field to create nano pores of cell membrane for the particle accessing into the cell through these channels.

In the simulation of different structure design analysis, it showed that the variations of micro electromagnetic field distribution were affected by the radius of inner ring, and would follow the height of insulated material to change. The distribution of the electromagnetic field will be better when the radius of inner ring is smaller. The width of the ring, the thickness of the depositional film and the opening angle of the ring all result in a little effect on the electromagnetic field.

As a result, it concludes that the simulation contributes to the design of gene chips to enhance the rate of the fluorescent gene transfection and the efficiency of the regional communications.

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