本研究主題是透過控制反應參數，合成具不同表面性質與組成的孔洞材料，並依照各材料之特性，應用於不同領域中。研究中合成了三種孔洞材料，包含有中孔洞氧化矽、鈣氧化矽複合材料以及矽酸鐵孔洞材料。首先大量製造高比表面積之中孔洞氧化矽材料，作為鈣、磷酸根離子載體用於封填牙本質小管，並針對治療牙本質過敏症研發新型牙本質封填材料。此外也成功地以酸化和煅燒過程，將木賊草轉為孔洞鈣氧化矽複合材料，同樣應用於牙本質小管的填補上。
過去治療牙本質過敏症的長效性問題於本研究中獲得了改善，中孔洞氧化矽於本新型牙本質封填材料的開發中扮演關鍵的角色，其多孔性能防止磷酸氫鈣於表面生成結晶，將鈣離子與磷酸根離子引入牙本質小管中，之後再行結晶便可達到良好封填的效果。本研究之新型牙本質封填材料可有效填補牙本質小管的鈣磷比範圍廣，因此未來應用於臨床治療上相當具有潛力。現今環保意識受到重視，為響應綠色化學的概念，將禾本科植物—木賊草，經酸洗處理並鍛燒移除有機物質所得到的鈣氧化矽複合材料，因為孔洞性質與中孔洞氧化矽相似，用於填補小管也達到良好牙本質封閉的效果。
另外，本研究也成功使用反滴定法將鐵離子引入氧化矽中，合成矽酸鐵孔洞材料可用來作為鍶離子的吸附劑。本實驗所使用的反滴定法將硝酸鐵同時作為酸源與鐵離子源，以滴定方式進入矽酸鈉中進行反應，無須經過水熱處理便可獲得高比表面積之矽酸鐵孔洞材料，於未來大量生產可省下龐大的能源花費。矽酸鐵孔洞材料表面帶有負電位置，因此在鍶離子的吸附上有良好的選擇性和移除率，其吸附容量高 (54.05 mg/g)。將矽酸鐵孔洞材料結合褐藻酸鈣進行造粒之後，成功解決的吸附劑於溶液中回收的問題，在未來實際應用上有發展潛力。

Porous materials with tunable surface properties were synthesized through an appropriate control of the reaction pH value, hydrothermal processing parameters, and calcination temperature. In this study, the porous materials presented two applications, namely the occlusion of dentinal tubules and the adsorption of strontium ions. Three porous materials were prepared: mesoporous silica (MS), porous calcium oxide-silica composite (CaO-SiO2 composite), and iron phyllosilicate. The MS was used to deliver calcium and phosphate ions into dentinal tubules, whereupon they formed CaHPO4·2H2O (denoted as DCPD) crystal to a depth of approximately 60 μm under optimal conditions. In accordance with the principles of green chemistry, the CaO-SiO2 composite was prepared from. Equisetum hyemale, which was acid washed to remove ions other than calcium and then calcinated to remove any remaining organics. The porous CaO-SiO2 composite showed similar surface properties to those of the MS. Moreover, it achieved a dentinal tubule penetration depth of nearly 90 μm. Consequently, it showed a good potential for the mitigation of dentin hypersensitivity. Iron phyllosilicate was synthesized using a back-titration method; thereby eliminating the need for additional acid sources and reducing the energy cost by removing the need for hydrothermal processing. The synthesized material was found to have a high specific surface area 329 m2/g and a good dispersion. When used as an adsorbent for strontium ions in waste water, it showed a maximum adsorption capacity of around 54.05 mg/g. Moreover, when combined with calcium alginate to achieve granulation by extrusion-dripping, the iron phyllosilicate showed a good potential as a fixed bed column filler adsorbate.

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