由印度Rao教授提供之A. echioides全草甲醇粗抽物704g，以氯仿與水進行多次分配萃取，得到氯仿層及水層。各分劃層利用管柱層析、薄層層析及再結晶等方法分離純化。目前共分離得到41個化合物，其中41個經光譜分析，確定其化學結構分別為：flavonoids：pinostrobin、dihydroechioidinin、(2R)-andro- gechoside-B、tectochrysin、7,8-dimethoxy-5-hydroxyflavone、5,7,8-trimethoxy- flavone、5,7-dimethoxyflavone、5,7,2′-trimethoxyflavone、echioidinin、echioidinin 5-O-β-D-glucopyranoside、skullcapflavone I 2′-O-β-D- glucopyranoside、tectochrysin 5-glucoside、skullcapflavone I 2′-methyl ether、negletein 6-O-β-D-glucopyranoside、echioidin、androgechoside-A、androechin、andrographidine C、andrographidine E、 skullcapflavone I等20個化合物；benzenoids：4-hydroxy- 3-methoxy-trans-cinnamic acid methyl ester、4-hydroxybenzaldehyde、4-hydroxy- trans-cinnamic acid methyl ester、methyl salicylate glucoside、o-coumaric acid、androechioside A、androechioside B、androechioside C、androechioside D、2, 6-dihydroxybenzoic acid 等10個化合物；chlorophyll：132-hydroxy- (132-R)-phaeophytin 1個化合物；diterpenes：(E)-phytyl epoxide、phytol 等2個化合物；ionones：dehydrovomifoliol、3β-hydroxy- 5α, 6α-epoxy-7-megastigmen-9-one 等2個化合物；sterols：β-sitosterol、β-sitosteryl- 3-O-β-glucopyranoside 等2個化合物；others：squalene、1H-indole-3-carbaldehyde、 loliolide 等3個化合物。其中androgechoside-A、(2R)-androgechoside-B、androechioside A、androechioside C、androechioside D等5個為新化合物，androechioside B為天然界首次分離得到之化合物。

Five new compounds, androgechoside-A, androgechoside-B, androechioside A, androechioside C, androechioside D and androechioside B that isolated from the natural sources for the first time; together with thirty five known compounds, included flavonoids: pinostrobin, dihydroechioidinin, tectochrysin, 7,8-dimethoxy- 5-hydroxyflavone, 5,7,8-trimethoxyflavone, 5,7-dimethoxyflavone, 5,7,2’-tri- methoxyflavone, echioidinin, echioidinin 5-O-β-D-glucopyranoside, skullcapflavone I 2’-O-β-D-glucopyranoside, tectochrysin 5-glucoside, skullcapflavone I 2’-methyl ether, negletein 6-O-β-D-glucopyranoside, echioidin, androechin, andrographidine C, andrographidine E; benzenoids: 4-hydroxy-3-methoxy-trans-cinnamic acid methyl ester, 4-hydroxybenzaldehyde, 4-hydroxy-trans-cinnamic acid methyl ester, methyl salicylate glucoside, o-coumaric acid, 2, 6-dihydroxybenzoic acid; chlorophyll: 132-hydroxy-(132-R)-phaeophytin; diterpenes: (E)-phytyl epoxide, phytol; ionones: dehydrovomifoliol, 3β-hydroxy-5α, 6α-epoxy-7-megastigmen-9-one; sterols: β-sito- sterol, β-sitosteryl-3-O-β-glucopyranoside; others: squalene, 1H-indole-3-carb- aldehyde, loliolide respectively were isolated from A. echioides Nees. Their structures were determined by 1H-, 13C-, 2D-NMR and MS spectroscopic analyses.

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