近年來研究學者發現對疏水性高的材料表面進行改質，使其變成高親水性表面，可以有效的防止不特定的生物分子貼附行為發生，抗貼附材料發展至今已經可歸納出主要兩大類：親水性高分子和雙電性離子，將此二者固定在基材表面可以使其帶有抵抗生物因子貼附的功能。
在本文中，設計在聚丙烯(polypropylene)基板上透過接枝的方法將親水性高分子環氧基系聚乙二醇Poly(ethylene glycol) diglycidyl ether (PEGDE)鍵結在表面上，再藉由接枝上琥珀醯鹽酸鹽(succinyl chloride)、2-二甲基胺基乙醇(2-dimethylaminoethanol)和1,3-丙烷磺內酯(1,3-propanesultone)來產生雙電性離子的結構，以此來和單純只接枝上PEGDE或雙電性離子的樣品進行比較，探討是否可以藉由此方法使抗貼附功能得到更進一步的增強。在每一個接枝步驟結束後，會利用FTIR和XPS來確認接枝是否成功，並且測量樣品之靜態接觸角來觀察親水性的變化，之後將一同接枝上親水性高分子和雙電性離子的樣品和未經改質之基材以及單純只接枝上親水性高分子或雙電性離子之樣品在抗菌貼附和血液相容性這兩方面進行比較。
從實驗結果中可以發現，經過親水性高分子和雙電性離子改質後的基材表面展現了較佳的親水性、數量更少的細菌和血小板貼附，可以證明生醫材料表面變得親水就可以展現出優秀的抗菌貼附功能和較佳的血液相容性，其中無論是從細菌還是血小板貼附實驗的結果可以得知，將親水性高分子和雙電性離子一起接枝到材料表面可以使其抗貼附的功能比單純只接枝其中一種抗貼附材料來的更好，這證明了此法在生醫材料方面具有發展的潛能。

In recent years, researchers have discovered that the surface of highly hydrophobic materials could be modified to become a hydrophilic surface, which could effectively prevent the non-specific adhesion of biological factors. The development of anti-adhesive materials could be mainly summarized into two categories: hydrophilic polymers and zwitterionic compounds. The two materials could make the surface of the substrates be able to resist the non-specific adhesion of biological factors by fixing them onto the substrates. In this article, the hydrophilic polymer and zwitterionic compound were fixed onto the polypropylene plate together to make it become highly hydrophilic to have stronger resistance to the non-specific adhesion of biological factors than the substrate was modified by only hydrophilic polymer or zwitterionic compound. First, poly(ethylene glycol) diglycidyl ether(PEGDE) was grafted onto the polypropylene plate. Then form the zwitterionic structure by making the succinyl chloride, 2-dimethylaminoethanol and 1,3-propanesultone be grafted onto the substrate. It would let the substrate be modified by PEGDE and zwitterionic compound. The samples were characterized using a variety of testing methods. It was noted that the samples modified via PEGDE and/or zwitterionic compound showed higher hydrophilicity than the unmodified substrate. Anti-adhesion tests exhibited that the samples modified by PEGDE and zwitterionic compound together possessed better anti-adhesion properties against Staphylococcus aureus, Escherichia coli and platelet than the samples modified by only PEGDE or zwitterionic compound. In conclusion, this work successfully fixed the hydrophilic polymer and zwitterionic onto the PP plate together and it showed excellent antibacterial adhesion and hemocompatility properties.

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