人工髖關節置換後，經過長時間的使用卻有失效的現象產生。究其原因，最主要的現象就是植入物的鬆脫(loosening)，以及骨質流失(bone resorption)。若使用骨泥(PMMA)人工髖關節置換，其主要鬆脫影響因素，是由於骨泥與骨頭中間被一層纖維組織所圍繞，因此PMMA 並沒有直接固定於骨頭，而沒有達到所謂的固定效果。

　　本實驗利用磷酸鈣骨水泥(Calcium phosphate)具有良好的誘骨性，可植入於骨骼部位，使新骨向內生長，。將磷酸鈣骨水泥應用於金屬植入材周圍，使金屬與骨頭之間，藉著骨頭的生長，因而增強其鍵結強度，因而提供其機械性固定效果。

　　實驗結果發現，隨著時間的增加，骨頭向內長比例也因而增加，因此其拉伸強度也有增強。有添加磷酸鈣骨水泥的骨頭，比沒添加的，其拉伸強度也來的大。隨著時間的增加，其差異程度也因而增大。並由組織切片上發現，時間的增加，金屬棒周圍新長的骨頭，有明顯增加的趨勢，因此，磷酸鈣骨水泥能提供金屬棒與骨頭有良好的固定效果。

　　Since 1970, many successful results have been reported of total hip replacement(THR) using polymethylmethacrylate(PMMA),but there have also been failures of fixation and the apparent incidence of aseptic loosening has increasing. The fixation strength of PMMA cement to bone is mainly dependent on mechanical interlocking, but it is know that a fibrous tissue layer intervenes between cement and bone; PMMA cement never bonds directly to bone. Other problems with PMMA cement include the biological response, leakage of the monomer of methylmethacrylate and a high curing temperature which damages cell activity.

　　We have developed Calcium phosphate(CPC) which bonds directly to bone with high strength and has a low curing temperature.Calcium phosphate have good osteoinduction, it could induce surrounding tissue to become osteoblast. We take this advantage for fixation implant with bone.

　　From results reveal that with CPC sample have higher pullout strength than without CPC sample. In addition, with implantation time increase, we find out new bone generated percentage also increased. More generated new bone could contribute high pullout strength. Sample with CPC implant twelve weeks has higher strength than implant one week or four weeks. Without CPC has the same tendency. We have developed Calcium phosphate which has good fixation with time increase.

劉堂桂，人工髖關節置換術之回顧，中華民國第一次骨科研究學會專題課程講義，主題：人工髖關節，民國八十三年七月，林口。

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