奈米材料發展至今，已有許多關於生醫領域的探索與應用，其中尤以磁性奈米粒子及金奈米粒子較為廣泛被研究；磁性奈米粒子可應用於磁導引、磁共振造影等方面，而金奈米粒子具有特殊的表面電漿共振吸收，可做光熱治療之應用。此外，以奈米材料作為抗癌藥物載體的應用亦蓬勃發展中，近年來，有許多利用中孔洞二氧化矽材料作為藥物載體之研究，若能再配合可受外界環境刺激打開的孔洞蓋子，則可達到抗癌藥物的控制釋放，使在治療時，可使用更少量的抗癌藥物即可達到治療效果。
本研究中，以四氧化三鐵－金核殼結構作為奈米藥物載體的核心粒子，使其可同時具有磁導引、磁共振造影及光熱治療的效果，另外，四氧化三鐵－金核殼結構外部包覆上中孔洞二氧化矽殼層，將抗癌藥物doxorubicin裝載於孔洞內，最後再以雙股去氧核醣核酸(deoxyribonucleic acid，DNA)作為藥物載體的開關，並以近紅外光驅動雙股DNA去雜交，達到藥物之控制釋放進而有效殺死癌細胞。
　　此外，本研究中所使用的材料同時具有光熱治療及化學藥物治療之功效，實驗結果顯示，將此兩種治療方式結合在同一個系統中，可達到結合治療之偕同效應(synergistic effect)效果，進而更有效殺死癌細胞。

Since the date that nanomaterial been developed, there’re numerous related explorations and application in biomedical field. Upon all kind of the nanomaterials, magnetic nanoparticles and gold nanomaterials are more extensively researched. Magnetic nanoparticles can be used in magnetic targeting, magnetic resonance imaging (MRI), etc., whereas gold nanomaterials can be applied in photothermal therapy because of the surface plasma resonance character of gold nanomaterials. Furthermore, the application of nanomaterials as anti-cancer drug carrier has been widely developed. For example, there’re many study about mesoporous silica nanomaterial, which can be used as drug carrier. Supposing that there’re stimuli-responsive caps attached on the mesoporous silica nanomaterial surface which can be the switch of the drug, we may attain the goal to control anti-cancer drug release. In addition, we may be able to use less amount of the drug to reach the effective cancer therapy.
In this study, we take iron oxide coated gold nanoshell (Fe3O4@Au) as the core of the nanocarrier, which can be applied to magnetic targeting, MRI, and thermotherapy. Moreover, coating mesoporous silica shell on Fe3O4@Au core may render us to load doxorubicin (an anti-cancer drug) into the pores of mesoporous silica shell. At last, we use stimuli-responsive double stranded deoxyribonucleic acid (dsDNA) as the caps to cover the pore which loaded doxorubicin. Owing to the stimuli-responsive caps, we are able to use NIR laser light to trigger doxorubicin release, and achieve the purpose of controlling drug release.

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