慢性腎臟病患的生活品質變化能評估醫療照護品質與預測醫療支出，現今探討慢性腎臟病患生活品質的研究，多使用一般性生活品質量表，或僅探討症狀較明顯的期別；除了易造成研究結果偏差，也無法真正瞭解其生活品質全貌。本研究目的為探討慢性腎臟病患生活品質及影響因素，採次級資料庫分析，資料來源為「世界衛生組織生活品質量表與腎臟疾病生活品質量表於慢性腎臟病患者使用之比較」研究案；原始資料來源採立意及分層取樣方式，納入南部某醫學中心、區域醫院、血液透析診所一到五期慢性腎臟病患；並以線性迴歸呈現研究結果。
研究結果顯示，腎臟疾病對每日生活影響分數最高，分數越高代表生活品質越好；高教育程度、無罹患心血管疾病為生理層面影響因子（p < .005）；男性、高腎絲球過濾率為心理層面影響因子（p < .005）；男性、未婚或無伴侶、高血清白蛋白、高腎絲球過濾率為症狀/問題層面影響因子（p < .005）；男性、未婚或無伴侶、高血清白蛋白、高腎絲球過濾率為腎臟疾病負擔層面影響因子（p < .005）；高腎絲球過濾率為腎臟疾病對每日生活影響層面的影響因子（p < .005）。
女性、低教育程度、已婚、罹患心血管疾病、低腎絲球過濾率、低血清白蛋白者，為腎臟疾病生活品質受損的高危險群，建議針對高危險群施行介入措施、著重於腎臟疾病負擔層面評估。本研究結果呈現出影響腎臟病患生活品質的因素及其生活品質；有助於制定健康照護政策之參考。

The Health- related quality of life (HRQOL) of patients who have been diagnosed with chronic kidney disease (CKD) was investigated in this study. Most previous studies have not included patients representing all five stages of CKD in analyses and have used only generic instrument. Bias might occur when researchers infer results regarding HRQOL based on only some of the stages of CKD.
The cross- sectional study was conducted with purposive and stratified samplings. Patients diagnosed with CKD stage 1 to 5 were selected from medical center, local hospitals and hemodialysis clinic in Southern Taiwan. Linear regression was used. The results indicated that the Effect of kidney disease (EKD) component received the higher score among KDQOL- 36TM components, in which a higher score indicated a higher HRQOL.
And the results of linear regression analysis revealed that higher education, absence cardiovascular disease positively influence physical component summary (PCS); male gender, higher glomerular filtration rate (GFR) positively influence mentle component summary (MCS); male gender, an unmarried status, higher albumin level, higher GFR positively influence symptom/ problem related to kidney diease component (SP) and burden of kidney disease (BKD); only higher GFR influence effect of kidney disease on daily life component.
There were multiple high- risk factor of low health- related quality of life occurrence with female, low level of education, married status, cardiovascular disease, low albumin level, and low GFR level. The strongly evidence in this study indicator that health provider not only apply health promotion program to high- risk group, but also evaluation on their BKD component is more important than others.

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