蘭嶼豬為台灣特有的小型豬種，其解剖與生理特性表現具有作為心肌梗塞大型動物模式的潛力，特別適用於心臟再生療法相關研究。本研究旨在建立一套兼具重現性且存活率高的蘭嶼豬心肌梗塞模型，作為模擬梗塞後心臟衰竭之病理狀態。共計有十七隻蘭嶼豬接受可植入式心律監測器的植入，並進行冠狀動脈左前降支球囊阻斷之缺血及再灌流手術。研究團隊於心肌梗塞誘發前後，透過經胸前心臟超音波及壓力容積環分析評估心臟功能，並於心肌梗塞後執行心肌內細胞注射，並持續追蹤其功能變化。

本模型於實驗期間達成94.1%的存活率。左心室射出分率於心肌梗塞後顯著下降，包含心臟超音波由69.4%降至40.0%；壓力容積環分析則是由66.1%降至46.2%。其他指標如心搏出量、做功量與心肌收縮力相關參數亦顯著下降。值得注意的是，未觀察到持續性惡性心律不整。整體來說梗塞範圍穩定，並持續造成心肌收縮功能障礙，顯示本模型具良好再現性與實驗價值。

本研究證實蘭嶼豬為建立高存活率且穩定的心肌梗塞模型之理想動物平台，適合用於再生療法之前臨床評估。其體型小、基因穩定性高且生理反應穩定，具備成為轉譯性心臟研究動物模式的優勢。

Lanyu pigs, a unique Taiwanese miniature breed, may offer advantages as a large-animal model for myocardial infarction (MI) studies, particularly in regenerative therapy research. This study aimed to establish and characterize a reproducible and survival-favorable MI model in Lanyu pigs, mimicking post-infarction heart failure. Seventeen Lanyu pigs underwent implantation of insertable cardiac monitors, followed by ischemia-reperfusion surgery via 90-minute balloon occlusion of the mid-left anterior descending artery. Cardiac function was evaluated pre- and post-MI using transthoracic echocardiography and pressure-volume (PV) loop analysis. Intramyocardial cell therapy was performed after infarction, and functional parameters were tracked longitudinally.

The model achieved a 94.1% survival rate. Left ventricular ejection fraction declined significantly post-MI (echocardiography: 69.4% to 40.0%; PV loop: 66.1% to 46.2%). Other parameters such as stroke volume, stroke work, and myocardial contractility indices also showed significant reduction. Importantly, no sustained malignant arrhythmias were observed. The infarction was consistent and resulted in persistent contractile impairment, confirming the model's validity.

This study demonstrates that Lanyu pigs are suitable for modeling MI with high survival and reproducibility, making them a valuable platform for evaluating regenerative therapies. Their small size, genetic stability, and favorable physiological response position them as an ideal model for translational cardiac research.

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