本研究利用微機電製程技術在銦錫氧化物(Indium tin oxide, ITO)玻璃基板上製作成所需之微加熱器晶片，並且以驅動電壓控制可加熱式微流體晶片的加熱溫度；微加熱器在本實驗中目的為提供加熱明膠以生成不同粒徑之乳化球所需，本研究以不同輸入電壓控制溫度，而溫度有效地控制在26ºC增加至96ºC。本研究結合微加熱器及微流體晶片為可加熱式微流體晶片，利用微流體晶片中十字流道的鞘流原理產出均一粒徑之明膠乳化球，並且探討了分離相流量、連續相流量和驅動電壓對於生成之乳化球大小之關係。由實驗可得知，當固定分離相流量時，越大的分離相流量，將得以生成越小的乳化球；當固定分離相流量時，越高的驅動電壓，將得以生成越大的乳化球，實驗中粒徑分佈範圍介於45 μm ~120 μm之間。最後將此生成之明膠乳化球包覆維他命C，並置於磷酸鹽緩衝溶液中進行維他命C釋放，證明本研究所設計的可加熱式微流體晶片可用於溫度敏感型材料上，且能製備出均一粒徑之乳化球。

In this study, the microheater is fabricated by using MEMS process on Indium tin oxide (ITO) glass slides, and it is driven by different voltage to control the temperature of the heatable microfluidic chip. The polydimethylsilcoxane (PDMS) microfluidic chip is fabricated by the same way, and combins with microheater which offers heat for generating different size of gelatin emulsions. The heatable microfluidic chip includes microheater and microfluidic chip, and it generates uniform-sized gelatin emulsions by flow focusing, which is made by cross shape microfluidic chips. In addition, we discussed the relationship of flow rate of dispersed phase, flow rate of continuous phase anddriven voltage to the size of generated emulsions. Results confirmd that when fixing the flow rate of disperse phase, increase the flow rate of continuous phase will generate smLler emulsions. On the other hand, when fixing flow rate of disperse phase, increase the driven voltage will generate larger emulsions. The size can be controlled from 59.9 µm to 105.2 µm in diameter, and then the microcapsules are placed in the phosphate buffer saline (PBS) for drug release. It confirm that the heatable microfluidic chip can be used to generate uniform-sized emulsions with temperature-sensitive polymer materials.

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