由松杉靈芝子實體(Ganoderma tsugae Murr.)分離與純化，共得到56個化合物，其中50個化合物經光譜分析，確定其化學結構，分別為ganoderic acids A-C, AM1、E、G、C6、V1和Y、methyl ganoderates A-C及H、ganoderal A、ganodermanontriol、ganoderiol A、lucidenic acid C、methyl lucidenates A、D及F、lucidones A-C、 ganodertsugins A-H、ganodertsugone A、15-hydroxy-ganoderic acid S、(S)-6-hydroxy-2-methyl-4-oxo-6-(4,4,13,14-tetramethyl-3,7,11,15-tetraoxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17- tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-heptanoic acid、4,4,14-trimethyl-3,7,11,15,20- pentaoxo-5-pregn-8-en、7,15-dihydroxy-3,11,23-trioxo-5-lanost-8-en-26-oic acid、5,8-epidioxy-5,8- ergosta-6,22t-dien-3-ol, 5-ergosta-7,22-dien-3-ol, 5-ergosta-7,22-dien-3-one, ergosterol, 2,3,9-trihydroxyergosta-7,22-diene, ergosta-4,6,8(14),22-tetraen-3-one, (24E)-3-oxo-lanosta-8-24-dien-26-oic-acid、thraustochytroside C、4-hydroxybenzaldehyde、vanillic acid、5-hydroxymethyl furfural、4-hydroxybenzoic acid、gallic acid methyl ester和 hexadecanoic acid，其中ganodertsugins A-H為新化合物，ganodertsugone A為首次發現新骨架化合物。上述化合物的結構利用質譜、核磁共振光譜、紅外光譜、紫外光譜等來加以決定，而已知化合物與文獻的物理與化學光譜數據進行比對得到確認。

Phytochemical investigation on the methanolic extract of the fruiting bodies of
Ganoderma tsugae Murr. afforded fifty-six compounds. Among them, fifty were identified by spectroscopic analyses as ganoderic acids A─C, AM1, C6, E, G, V1 and Y, methyl ganoderates A─C and H, ganoderal A, ganodermanontriol, ganoderiol A, lucidenic acid C, methyl lucidenates A, D and F, lucidones A─C, ganodertsugins A─H, ganodertsugone A, 15-hydroxy-ganoderic acid S, (S)-6-hydroxy-2-methyl-4-oxo-6- (4,4,13,14-tetramethyl-3,7,11,15-tetraoxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17- tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-heptanoic acid, 4,4,14-trimethyl-3,7,11,15,20- pentaoxo-5-pregn-8-en, 7,15-dihydroxy-3,11,23-trioxo-5-lanost-8-en-26-oic acid, 5,8-epidioxy-5,8- ergosta-6,22t-dien-3-ol, 5-ergosta-7,22-dien-3-ol, 5-ergosta-7,22-dien-3-one, ergosterol, 2,3,9-trihydroxyergosta-7,22-diene, ergosta-4,6,8(14),22-tetraen-3-one, (24E)-3-oxo-lanosta-8-24-dien-26-oic-acid, thraustochytroside C, 4-hydroxybenzaldehyde, vanillic acid, 5-hydroxymethyl furfural, 4-hydroxybenzoic acid, gallic acid methyl ester and hexadecanoic acid. Among these isolates, eight compounds namely ganodertsugins A─H were new compounds and ganodertsugone A was new with unprecedented carbon skeleton. The structures of all new compounds were determined by 1H, 13C, 2D-NMR and MS spectral analyses. The known compounds were identified by comparison of their physical and spectral data with those reported in the literature.

1. 國家中醫藥管理局《中華本草》編委會, 中華本草. 上海科學技術出版社: 上海,第一冊, 534-542頁.
2. 趙繼鼎; 徐連旺; 張小青, "中國靈芝分類研究. "真菌學報, 1984, 3, 13-23頁.
3. T. Miyazaki; M. Nishijima, "Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum. " Chem. Pharm. Bull. 1981, 29, 3611-3616.
4. H. Maruyama; K. Yamazaki; S. Murofushi; C. Konda; T. Ikekawa, "Antitumor activity of Sarcodon aspratus (Berk.) S. Ito and Ganoderma lucidum (Fr.) Karst. " J. Pharmacobiodyn., 1989, 12, 118-123.
5. K. Kino; T. Sone; J. Watanabe; A. Yamashita; H. Tsuboi; H. Miyajima; H. Tsunoo, "Immunomodulator, LZ-8, prevents antibody production in mice. " Int. J. Immunopharmacol., 1991, 13, 1109-1115.【C.A. 116: 34145（1991）】
6. C. N. Lin; W. P. Tome; S. J. Won, "Novel cytotoxic principles of Formosan Ganoderma lucidum. " J. Nat. Prod., 1991, 54, 998-1002.
7. C. W. Lieu; S. S. Lee; S. Y. Wang, "The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells. " Anticancer Res., 1992, 12, 1211-1215.
8. G. Wang; J. Zhang; T. Mizuno; C. Zhuang; H. Ito; H. Mayuzumi; H. Okamoto; J. Li, "Antitumor active polysaccharides from the Chinese mushroom Songshan lingzhi, the fruiting body of Ganoderma tsugae. " Biosci. Biotechnol. Biochem., 1993, 57, 894-900.
9. S. Y. Wang; M. L. Hsu; H. C. Hsu; C. H. Tzeng; S. S. Lee; M. S. Shiao; C. K. Ho, "The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. " Int. J. Cancer, 1997, 70, 699-705.
10. R. S. Kim; H. W. Kim; B. K. Kim, "Suppressive effects of Ganoderma lucidum on proliferation of peripheral blood mononuclear cells. " Mol. Cells, 1997, 7, 52-57.
11. Y. Mizushina; I. Watanabe; H. Togashi; L. Hanashima; M. Takemura; K. Ohta; F. Sugawara; H. Koshino; Y. Esumi; J. Uzawa; A. Matsukage; S. Yoshida; K. Sakaguchi, "An ergosterol peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on DNA polymerase beta. " Biol. Pharm. Bull., 1998, 21, 444-448.
12. Y. Mizushina; L. Hanashima; T. Yamaguchi; M. Takemura; F. Sugawara; M. Saneyoshi; A. Matsukage; S. Yoshida; K. Sakaguchi, "A mushroom fruiting body-inducing substance inhibits activities of replicative DNA polymerases. " Biochem. Biophys. Res. Commun., 1998, 249, 17-22.
13. S. Lee; S. Park; J. W. Oh; C. Yang, "Natural inhibitors for protein prenyltransferase. " Planta Med., 1998, 64, 303-308.【C.A. 129: 72037（1998）】
14. K. H. Gan; Y. F. Fann; S. H. Hsu; K. W. Kuo; C. N. Lin, "Mediation of the cytotoxicity of lanostanoids and steroids of Ganoderma tsugae through apoptosis and cell cycle. " J. Nat. Prod., 1998, 61, 485-487.
15. L. Zhong; D. Jiang; Q. Wang, "Effects of Ganoderma lucidum (Leyss ex Fr) Karst compound on the proliferation and differentiation of K562 leukemic cells. " Hunan Yi Ke Da Xue Xue Bao, 1999, 24, 521-524.
16. Y. Mizushina; N. Takahashi; L. Hanashima; H. Koshino; Y. Esumi; J. Uzawa; F. Sugawara; K. Sakaguchi, "Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. " Bioorg. Med. Chem., 1999, 7, 2047-2052.
17. Q. Zhang; Z. Lin, "Study on antitumor activity and mechanism of Ganoderma polysaccharides B. " Zhongguo Zhong Xi Yi Jie He Za Zhi, 1999, 19, 544-547.
18. H. S. Zhu; X. L. Yang; L. B. Wang; D. X. Zhao; L. Chen, "Effects of extracts from sporoderm-broken spores of Ganoderma lucidum on HeLa cells. " Cell Biol. Toxicol., 2000, 16, 201-206.
19. H. J. Su; Y. F. Fann; M. I. Chung; S. J. Won; C. N. Lin, "New lanostanoids of Ganoderma tsugae. " J. Nat. Prod., 2000, 63, 514-516.
20. B. S. Min; J. J. Gao; N. Nakamura; M. Hattori, "Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. " Chem. Pharm. Bull., 2000, 48, 1026-1033.
21. T. B. Ha; C. Gerhauser; W. D. Zhang; N. Ho-Chong-Line; I. Fouraste, "New lanostanoids from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured hepalcic7 murine hepatoma cells. " Planta Med., 2000, 66, 681-684.
22. E. M. Giner-Larza; S. Manez; R. M. Giner-Pons; M. Carmen Recio; J. L. Rios, "On the anti-inflammatory and anti-phospholipase A(2) activity of extracts from lanostane-rich species. " J. Ethnopharmacol., 2000, 73, 61-69.
23. P. Li; K. Zhang, "Isolation, purification and bioactivities of exopoly saccharides from fermented broth of Ganoderma lucidum. " Wei Sheng Wu Xue Bao, 2000, 40, 217-220.
24. A. de la Taille; O. R. Hayek; M. Burchardt; T. Burchardt; A. E. Katz, "Role of herbal compounds (PC-SPES) in hormone-refractory prostate cancer: two case reports. " J. Altern. Complement. Med., 2000, 6, 449-451.
25. T. S. Wu; L. S. Shi; S. C. Kuo, "Cytotoxicity of Ganoderma lucidum triterpenes. " J. Nat. Prod., 2001, 64, 1121-1122.
26. H. Lu; T. Uesaka; O. Katoh; E. Kyo; H. Watanabe, "Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats. " Oncol. Rep., 2001, 8, 1341-1345.
27. J. M. Lee; H. Kwon; H. Jeong; J. W. Lee; S. Y. Lee; S. J. Baek; Y. J. Surh, "Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. " Phytother. Res., 2001, 15, 245-249.【C.A. 136: 177579（2001）】
28. W. T. Chung; S. H. Lee; J. D. Kim; Y. S. Park; B. Hwang; S. Y. Lee; H. Y. Lee, "Effect of mycelial culture broth of Ganoderma lucidum on the growth characteristics of human cell lines. " J. Biosci. Bioeng., 2001, 92, 550-555.
29. D. Sliva; C. Labarrere; V. Slivova; M. Sedlak; F. P. Lloyd, Jr.; N. W. Ho, "Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. " Biochem. Biophys. Res. Commun., 2002, 298, 603-612.
30. H. Lu; E. Kyo; T. Uesaka; O. Katoh; H. Watanabe, "Prevention of development of N,N'-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male ICR mice. " Int. J. Mol. Med., 2002, 9, 113-117.
31. X. Liu; J. P. Yuan; C. K. Chung; X. J. Chen, "Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum. " Cancer Lett., 2002, 182, 155-161.
32. Y. Kimura; M. Taniguchi; K. Baba, "Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. " Anticancer Res., 2002, 22, 3309-3318.【C.A. 139: 207197（2002）】
33. H. Hu; N. S. Ahn; X. Yang; Y. S. Lee; K. S. Kang, "Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. " Int. J. Cancer, 2002, 102, 250-253.
34. A. G. Gonzalez; F. Leon; A. Rivera; J. I. Padron; J. Gonzalez-Plata; J. C. Zuluaga; J. Quintana; F. Estevez; J. Bermejo, "New lanostanoids from the fungus Ganoderma concinna. " J. Nat. Prod., 2002, 65, 417-421.
35. J. J. Gao; B. S. Min; E. M. Ahn; N. Nakamura; H. K. Lee; M. Hattori, "New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells. " Chem. Pharm. Bull., 2002, 50, 837-840.
36. D. Sliva; M. Sedlak; V. Slivova; T. Valachovicova; F. P. Lloyd, Jr.; N. W. Ho, "Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells. " J. Altern. Complement. Med., 2003, 9, 491-497.
37. D. Sliva, "Ganoderma lucidum (Reishi) in cancer treatment. " Integr. Cancer Ther., 2003, 2, 358-364.
38. M. S. Shiao, "Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions. " Chem. Rec., 2003, 3, 172-180.
39. J. Ning; W. Zhang; Y. Yi; G. Yang; Z. Wu; J. Yi; F. Kong, "Synthesis of beta-(1-->6)-branched -(1-->3) glucohexaose and its analogues containing an -(1-->3) linked bond with antitumor activity. " Bioorg. Med. Chem., 2003, 11, 2193-2203.
40. H. Lu; E. Kyo; T. Uesaka; O. Katoh; H. Watanabe, "A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethane-induction of colon cancers in male F344 rats. " Oncol. Rep., 2003, 10, 375-379.
41.S. B. Lin; C. H. Li; S. S. Lee; L. S. Kan, "Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. " Life Sci., 2003, 72, 2381-2390.
42. S. Tomasi; F. Lohezic-Le Devehat; P. Sauleau; C. Bezivin; J. Boustie, "Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines. " Pharmazie, 2004, 59, 290-293.【C.A. 142: 232635（2004）】
43. Q. Z. Cao; Z. B. Lin, "Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. " Acta. Pharmacol. Sin., 2004, 25, 833-838.
44. W. L. Hsiao; Y. Q. Li; T. L. Lee; N. Li; M. M. You; S. T. Chang, "Medicinal mushroom extracts inhibit ras-induced cell transformation and the inhibitory effect requires the presence of normal cells. " Carcinogenesis, 2004, 25, 1177-1183.
45. J. Jiang; V. Slivova; K. Harvey; T. Valachovicova; D. Sliva, "Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-B signaling. " Nutr. Cancer, 2004, 49, 209-216.
46. J. Jiang; V. Slivova; T. Valachovicova; K. Harvey; D. Sliva, "Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. " Int. J. Oncol., 2004, 24, 1093-1099.
47. Q. Y. Lu; Y. S. Jin; Q. Zhang; Z. Zhang; D. Heber; V. L. Go; F. P. Li; J. Y. Rao, "Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro. " Cancer Lett., 2004, 216, 9-20.
48. Q. Y. Lu; M. R. Sartippour; M. N. Brooks; Q. Zhang; M. Hardy; V. L. Go; F. P. Li; D. Heber, "Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro. " Oncol. Rep., 2004, 12, 659-662.
49. P. H. Ngai; T. B. Ng, "A mushroom (Ganoderma capense) lectin with spectacular thermostability, potent mitogenic activity on splenocytes, and antiproliferative activity toward tumor cells. " Biochem. Biophys. Res. Commun., 2004, 314, 988-993.
50. D. Sliva, "Cellular and physiological effects of Ganoderma lucidum (Reishi). " Mini Rev. Med. Chem., 2004, 4, 873-879.
51. H. L. Yang, "Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402. " Biotechnol. Lett., 2005, 27, 835-838.
52. B. Wang; Y. Hu; J. Li, "Effect of Ganoderma triterpene on proliferation of dendritic cells from mouse spleen. " Zhong Yao Cai, 2005, 28, 577-579.
53. Y. Jiang; H. Wang; L. Lu; G. Y. Tian, "Chemistry of polysaccharide Lzps-1 from Ganoderma lucidum spore and anti-tumor activity of its total polysaccharides. " Yao Xue Xue Bao, 2005, 40, 347-350.
54. C. Z. Wang; D. Basila; H. H. Aung; S. R. Mehendale; W. T. Chang; E. McEntee; X. Guan; C. S. Yuan, "Effects of Ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model. " Am. J. Chin. Med., 2005, 33, 807-815.
55. G. Stanley; K. Harvey; V. Slivova; J. Jiang; D. Sliva, "Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-1 from prostate cancer cells. " Biochem. Biophys. Res. Commun., 2005, 330, 46-52.
56. Y. Nonaka; H. Ishibashi; M. Nakai; H. Shibata; Y. Kiso; S. Abe, "Soothing effect of Ganoderma lucidum antlered form on cyclophosphamide-induced adverse reaction. " Gan To. Kagaku Ryoho, 2005, 32, 1586-1588.
57. C. H. Li; P. Y. Chen; U. M. Chang; L. S. Kan; W. H. Fang; K. S. Tsai; S. B. Lin, "Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells. " Life Sci., 2005, 77, 252-265.
58. N. Johnston, "Medicinal mushroom cuts off prostate cancer cells' blood supply. " Drug Discov. Today, 2005, 10, 1584.
59. Y. Gao; W. Tang; X. Dai; H. Gao; G. Chen; J. Ye; E. Chan; H. L. Koh; X. Li; S. Zhou, "Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer. " J. Med. Food., 2005, 8, 159-168.
60. Y. Gao; H. Gao; E. Chan; W. Tang; A. Xu; H. Yang; M. Huang; J. Lan; X. Li; W. Duan; C. Xu; S. Zhou, "Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice. " Immunol. Invest., 2005, 34, 171-198.【C.A. 143: 259626（2005）】
61. R. Fujita; J. Liu; K. Shimizu; F. Konishi; K. Noda; S. Kumamoto; C. Ueda; H. Tajiri; S. Kaneko; Y. Suimi; R. Kondo, "Anti-androgenic activities of Ganoderma lucidum. " J. Ethnopharmacol., 2005, 102, 107-112.
62. W. K. Chan; D. T. Lam; H. K. Law; W. T. Wong; M. W. Koo; A. S. Lau; Y. L. Lau; G. C. Chan, "Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy. " J. Altern. Complement. Med., 2005, 11, 1047-1057.
63. D. H. Wang; X. C. Weng, "Antitumor activity of extracts of Ganoderma lucidum and their protective effects on damaged HL-7702 cells induced by radiotherapy and chemotherapy. " Zhongguo Zhong Yao Za Zhi, 2006, 31, 1618-1622.
64. G. G. Yue; K. P. Fung; G. M. Tse; P. C. Leung; C. B. Lau, "Comparative studies of various Ganoderma species and their different parts with regard to their antitumor and immunomodulating activities in vitro. " J. Altern. Complement. Med., 2006, 12, 777-789.
65. W. Tang; J. W. Liu; W. M. Zhao; D. Z. Wei; J. J. Zhong, "Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. " Life Sci., 2006, 80, 205-211.
66. Y. Nonaka; H. Shibata; M. Nakai; H. Kurihara; H. Ishibashi; Y. Kiso; T. Tanaka; H. Yamaguchi; S. Abe, "Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice. " Biosci. Biotechnol. Biochem., 2006, 70, 2028-2034.
67. C. I. Muller; T. Kumagai; J. O'Kelly; N. P. Seeram; D. Heber; H. P. Koeffler, "Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. " Leuk. Res., 2006, 30, 841-848.
68. J. Liu; K. Kurashiki; K. Shimizu; R. Kondo, "5-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum. " Biol. Pharm. Bull., 2006, 29, 392-395.
69. C. H. Liao; Y. M. Hsiao; C. P. Hsu; M. Y. Lin; J. C. Wang; Y. L. Huang; J. L. Ko, "Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line. " Mol. Carcinog., 2006, 45, 220-229.
70. N. Kashimoto; M. Hayama; K. Kamiya; H. Watanabe, "Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats. " Oncol. Rep., 2006, 16, 1181-1187.
71. J. Jiang; V. Slivova; D. Sliva, "Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-B signaling. " Int. J. Oncol., 2006, 29, 695-703.
72. C. H. Chui; R. S. Wong; G. Y. Cheng; F. Y. Lau; S. H. Kok; C. H. Cheng; F. Cheung; W. K. Tang; I. T. Teo; A. S. Chan; J. C. Tang, "Antiproliferative ability of a combination regimen of crocodile egg extract, wild radix ginseng and natural Ganoderma lucidum on acute myelogenous leukemia. " Oncol. Rep., 2006, 16, 1313-1316.
73. X. Chen; Z. P. Hu; X. X. Yang; M. Huang; Y. Gao; W. Tang; S. Y. Chan; X. Dai; J. Ye; P. C. Ho; W. Duan; H. Y. Yang; Y. Z. Zhu; S. F. Zhou, "Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer. " Int. Immunopharmacol., 2006, 6, 499-508.
74. U. M. Chang; C. H. Li; L. I. Lin; C. P. Huang; L. S. Kan; S. B. Lin, "Ganoderiol F, a Ganoderma triterpene, induces senescence in hepatoma HepG2 cells. " Life Sci., 2006, 79, 1129-1139.
75. Q. Z. Cao; Z. B. Lin, "Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell. " Life Sci., 2006, 78, 1457-1463.
76. A. Thyagarajan; J. Jiang; A. Hopf; J. Adamec; D. Sliva, "Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. " Int. J. Mol. Med., 2006, 18, 657-664.
77. A. Thyagarajan; J. Zhu; D. Sliva, "Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. " Int. J. Oncol., 2007, 30, 963-969.
78. B. Z. Zaidman; S. P. Wasser; E. Nevo; J. Mahajna, "Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells. " Mol. Biol. Rep., 2007.
79. K. C. Kim; J. S. Kim; J. K. Son; I. G. Kim, "Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts. " Cancer Lett., 2007, 246, 210-217.
80. T. Akihisa; Y. Nakamura; M. Tagata; H. Tokuda; K. Yasukawa; E. Uchiyama; T. Suzuki; Y. Kimura, "Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum. " Chem. Biodivers., 2007, 4, 224-231.
81. X. Y. Lin; K. L. Huang; R. P. Zhu, "Therapeutic effect of Ganoderma applonatum (GA) on chronic hepatitis B. " Zhonghua Nei Ke Za Zhi, 1988, 27, 618-620, 652-613.
82. G. T. Liu; T. T. Bao; H. L. Wei; Z. Y. Song, "Some pharmacological effects of alcoholic extracts of Ganoderma lucidum and G. japonicum Llyod on mouse liver. " Yaoxue Xuebao, 1979, 14, 284-287.
83. G. T. Liu; G. F. Wang; H. L. Wei; T. T. Bao; Z. Y. Song, "A comparison of the protective actions of biphenyl dimethyl-dicarboxylate, trans-stilbene, alcoholic extracts of Fructus schizandrae and Ganoderma against experimental liver injury in mice (author's transl). " Yao Xue Xue Bao, 1979, 14, 598-604.
84. E. J. Park; G. Ko; J. Kim; D. H. Sohn, "Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction. " Biol. Pharm. Bull., 1997, 20, 417-420.
85. D. H. Kim; S. B. Shim; N. J. Kim; I. S. Jang, "-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum. " Biol. Pharm. Bull., 1999, 22, 162-164.【C.A. 162: 320809（1999）】
86. Y. H. Shieh; C. F. Liu; Y. K. Huang; J. Y. Yang; I. L. Wu; C. H. Lin; S. C. Li, "Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice. " Am. J. Chin. Med., 2001, 29, 501-507.
87. G. L. Zhang; Y. H. Wang; W. Ni; H. L. Teng; Z. B. Lin, "Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. " World J. Gastroenterol., 2002, 8, 728-733.
88. G. L. Xiao; F. Y. Liu; Z. H. Chen, "Clinical observation on treatment of Russula subnigricans poisoning patients by Ganoderma lucidum decoction. " Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003, 23, 278-280.
89. Y. W. Wu; K. D. Chen; W. C. Lin, "Effect of Ganoderma tsugae on chronically carbon tetrachloride-intoxicated rats. " Am. J. Chin. Med., 2004, 32, 841-850. 【C.A. 841: 87850（2004）】
90. Y. Q. Li; K. C. Zhang, "In vitro inhibitory efects on HBsAg and HBeAg secretion of 3 new components produced by Ganoderma lucidum in the medium contained Radix Sophorae Flavescentis extract. " Wei Sheng Wu Xue Bao, 2005, 45, 643-646.
91. X. J. Yang; J. Liu; L. B. Ye; F. Yang; L. Ye; J. R. Gao; Z. H. Wu, "In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury. " World J. Gastroenterol., 2006, 12, 1379-1385.
92. W. C. Lin; W. L. Lin, "Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats. " World J. Gastroenterol., 2006, 12, 265-270.
93. Y. Q. Li; S. F. Wang, "Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum. " Biotechnol Lett, 2006, 28, 837-841.
94. Y. Li; Y. Yang; L. Fang; Z. Zhang; J. Jin; K. Zhang, "Anti-hepatitis activities in the broth of Ganoderma lucidum supplemented with a Chinese herbal medicine. " Am. J. Chin. Med., 2006, 34, 341-349.
95. B. Lakshmi; T. A. Ajith; N. Jose; K. K. Janardhanan, "Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene. " J. Ethnopharmacol., 2006, 107, 297-303.
96. K. Chen; C. Li, "Recent advances in studies on traditional Chinese anti-aging materia medica. " J. Tradit. Chin. Med., 1993, 13, 223-226.
97. M. Zhu; Q. Chang; L. K. Wong; F. S. Chong; R. C. Li, "Triterpene antioxidants from Ganoderma lucidum. " Phytother. Res., 1999, 13, 529-531. 【C.A. 132: 161200（1999）】
98. K. C. Kim; I. G. Kim, "Ganoderma lucidum extract protects DNA from strand breakage caused by hydroxyl radical and UV irradiation. " Int. J. Mol. Med., 1999, 4, 273-277.
99. H. S. Kim; S. Kacew; B. M. Lee, "In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor). " Carcinogenesis, 1999, 20, 1637-1640.
100. H. M. Zhang; W. J. Yao; H. K. Tian, "Effect of fungus Ganoderma lucidum on low-density lipoprotein oxidation and monocyte adhesion to endothelium. " Zhongguo Zhong Xi Yi Jie He Za Zhi, 2002, 22, 534-537.
101. Y. H. You; Z. B. Lin, "Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen species. " Acta Pharmacol. Sin., 2002, 23, 787-791.
102. Y. L. Shi; A. E. James; I. F. Benzie; J. A. Buswell, "Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA. " Teratog. Carcinog. Mutagen., 2002, 22, 103-111.【C.A. 136: 162608（2002）】
103. J. L. Mau; H. C. Lin; C. C. Chen, "Antioxidant properties of several medicinal mushrooms. " J. Agric. Food Chem., 2002, 50, 6072-6077.
104. M. J. Hsu; S. S. Lee; W. W. Lin, "Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway. " J. Leukoc. Biol., 2002, 72, 207-216.【C.A. 137: 153784（2002）】
105. Y. H. You; Z. B. Lin, "Antioxidant effect of Ganoderma polysaccharide peptide. " Yao Xue Xue Bao, 2003, 38, 85-88.
106. B. Lakshmi; T. A. Ajith; N. Sheena; N. Gunapalan; K. K. Janardhanan, "Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India. " Teratog. Carcinog. Mutagen., 2003, Suppl 1, 85-97.【C.A. 140: 117081（2003）】
107. W. Y. Chung; C. M. Yow; I. F. Benzie, "Assessment of membrane protection by traditional Chinese medicines using a flow cytometric technique: preliminary findings. " Redox. Rep., 2003, 8, 31-33.
108. S. Q. Zhang; X. J. Shi, "Experimental study on cardiac protection and anti-oxidation effects of jisheng injection. " Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003, 23, 455-457.
109. K. L. Wong; H. H. Chao; P. Chan; L. P. Chang; C. F. Liu, "Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity. " Phytother. Res., 2004, 18, 1024-1026.
110. S. Wachtel-Galor; B. Tomlinson; I. F. Benzie, "Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. " Br. J. Nutr., 2004, 91, 263-269.
111. S. Wachtel-Galor; Y. T. Szeto; B. Tomlinson; I. F. Benzie, "Ganoderma lucidum ('Lingzhi'); acute and short-term biomarker response to supplementation. " Int. J. Food Sci. Nutr., 2004, 55, 75-83.
112. J. Sun; H. He; B. J. Xie, "Novel antioxidant peptides from fermented mushroom Ganoderma lucidum. " J. Agric. Food Chem., 2004, 52, 6646-6652.
113. C. W. Woo; R. Y. Man; Y. L. Siow; P. C. Choy; E. W. Wan; C. S. Lau; K. O, "Ganoderma lucidum inhibits inducible nitric oxide synthase expression in macrophages. " Mol. Cell. Biochem., 2005, 275, 165-171.
114. S. Wachtel-Galor; S. W. Choi; I. F. Benzie, "Effect of Ganoderma lucidum on human DNA is dose dependent and mediated by hydrogen peroxide. " Redox Rep., 2005, 10, 145-149.
115. K. Acharya; P. Yonzone; M. Rai; A. Rupa, "Antioxidant and nitric oxide synthase activation properties of Ganoderma applanatum. " Indian J. Exp. Biol., 2005, 43, 926-929.
116. J. T. Xie; C. Z. Wang; S. Wicks; J. J. Yin; J. Kong; J. Li; Y. C. Li; C. S. Yuan, "Ganoderma lucidum extract inhibits proliferation of SW 480 human colorectal cancer cells. " Exp. Oncol., 2006, 28, 25-29.【C.A. 135: 388837（2006）】
117. K. N. Lai; L. Y. Chan; S. C. Tang; J. C. Leung, "Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells. " Nephrol. Dial. Transplant., 2006, 21, 1188-1197.
118. J. Tao; K. Y. Feng, "Experimental and clinical studies on inhibitory effect of Ganoderma lucidum on platelet aggregation. " J. Tongji Med. Univ., 1990, 10, 240-243.
119. T. S. Wu; L. S. Shi; S. C. Kuo; C. Y. Chern; S. F. Tung; C. M. Teng, "Platelet aggregation inhibitor from Ganoderma lucidum. . " J. Chin. Chem. Soc., 1997, 44, 157-161.
120. C. Y. Su; M. S. Shiao; C. T. Wang, "Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets. " Biochem. Pharmacol., 1999, 58, 587-595.
121. C. Su; M. Shiao; C. Wang, "Potentiation of ganodermic acid S on prostaglandin E(1)-induced cyclic AMP elevation in human platelets. " Thromb. Res., 2000, 99, 135-145.【C.A. 133: 276072（2000）】
122. A. Argento; E. Tiraferri; M. Marzaloni, "Oral anticoagulants and medicinal plants. An emerging interaction. " Ann. Ital. Med. Int., 2000, 15, 139-143.
123. H. Hikino; C. Konno; Y. Mirin; T. Hayashi, "Isolation and hypoglycemic activity of ganoderans A and B, glycans of Ganoderma lucidum fruit bodies 1. " Planta Med., 1985, 51, 339-340.
124. H. Hikino; M. Ishiyama; Y. Suzuki; C. Konno, "Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies. " Planta Med., 1989, 55, 423-428. 【C.A. 112: 30465（1989）】
125. K. Kino; K. Mizumoto; T. Sone; T. Yamaji; J. Watanabe; A. Yamashita; K. Yamaoka; K. Shimizu; K. Ko; H. Tsunoo, "An immunomodulating protein, ling zhi-8 (LZ-8) prevents insulitis in non-obese diabetic mice. " Diabetologia, 1990, 33, 713-718.
126. H. N. Zhang; J. H. He; L. Yuan; Z. B. Lin, "In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage. " Life Sci., 2003, 73, 2307-2319.
127. N. Futrakul; M. Boonyen; S. Patumraj; P. Siriviriyakul; P. Tosukhowong; P. Futrakul, "Treatment of glomerular endothelial dysfunction in steroid-resistant nephrosis with Ganoderma lucidum, vitamins C, E and vasodilators. " Clin. Hemorheol. Microcirc., 2003, 29, 205-210.
128. H. N. Zhang; Z. B. Lin, "Hypoglycemic effect of Ganoderma lucidum polysaccharides. " Acta. Pharmacol. Sin., 2004, 25, 191-195.
129. S. Lee; S. H. Shim; J. S. Kim; K. H. Shin; S. S. Kang, "Aldose reductase inhibitors from the fruiting bodies of Ganoderma applanatum. " Biol. Pharm. Bull., 2005, 28, 1103-1105.
130. S. H. Jung; Y. S. Lee; S. H. Shim; S. Lee; K. H. Shin; J. S. Kim; Y. S. Kim; S. S. Kang, "Inhibitory effects of Ganoderma applanatum on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. " Phytother. Res., 2005, 19, 477-480.
131. K. H. Jung; E. Ha; M. J. Kim; Y. K. Uhm; H. K. Kim; S. J. Hong; J. H. Chung; S. V. Yim, "Ganoderma lucidum extract stimulates glucose uptake in L6 rat skeletal muscle cells. " Acta Biochim. Pol., 2006, 53, 597-601.
132. C. Y. He; W. D. Li; S. X. Guo; S. Q. Lin; Z. B. Lin, "Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice. " J. Asian Nat. Prod. Res., 2006, 8, 705-711.【C.A. 146: 308922（2006）】
133. A. E. Reade; R. E. McQueen, "Investigation of white-rot fungi for the conversion of poplar into a potential feedstuff for ruminants. " Can. J. Microbiol., 1983, 29, 457-463.
134. K. Tasaka; M. Akagi; K. Miyoshi; M. Mio; T. Makino, "Anti-allergic constituents in the culture medium of Ganoderma lucidum. (I). Inhibitory effect of oleic acid on histamine release. " Agents Actions, 1988, 23, 153-156.【C.A. 108: 198020（1988）】
135. K. Tasaka; M. Mio; K. Izushi; M. Akagi; T. Makino, "Anti-allergic constituents in the culture medium of Ganoderma lucidum. (II). The inhibitory effect of cyclooctasulfur on histamine release. " Agents Actions, 1988, 23, 157-160. 【C.A. 108: 198021（1988）】
136. S. Tanaka; K. Ko; K. Kino; K. Tsuchiya; A. Yamashita; A. Murasugi; S. Sakuma; H. Tsunoo, "Complete amino acid sequence of an immunomodulatory protein, ling zhi-8 (LZ-8). An immunomodulator from a fungus, Ganoderma lucidum, having similarity to immunoglobulin variable regions. " J. Biol. Chem., 1989, 264, 472 - 478.
137. T. Sasaki; Y. Arai; T. Ikekawa; G. Chihara; F. Fukuoka, "Antitumor polysaccharides from some polyporaceae, Ganoderma applanatum (Pers.) Pat. and Phellinus linteus (Berk. et Curt.) Aoshima. " Chem. Pharm. Bull., 1971, 19, 821-826.
138. S. M. Tarlo; B. Bell; J. Srinivasan; J. Dolovich; F. E. Hargreave, "Human sensitization to Ganoderma antigen. " J. Allergy Clin. Immunol., 1979, 64, 43-49.
139. L. S. Lei; Z. B. Lin, "Effect of Ganoderma polysaccharides on T cell subpopulations and production of interleukin 2 in mixed lymphocyte response. " Yao Xue Xue Bao, 1992, 27, 331-335.
140. S. J. Won; M. T. Lin; W. L. Wu, "Ganoderma tsugae mycelium enhances splenic natural killer cell activity and serum interferon production in mice. " Jpn. J. Pharmacol., 1992, 59, 171-176.
141. N. Miyasaka; H. Inoue; T. Totsuka; R. Koike; K. Kino; H. Tsunoo, "An immunomodulatory protein, ling zhi-8, facilitates cellular interaction through modulation of adhesion molecules. " Biochem. Biophys. Res. Commun., 1992, 186, 385-390.
142. L. X. Zhang; H. Mong; X. B. Zhou, "Effect of Japanese Ganoderma lucidum on production of interleukin-2 from murine splenocytes. " Zhongguo Zhong Xi Yi Jie He Za Zhi, 1993, 13, 613-615, 582.
143. L. S. Lei; Z. B. Lin, "Effects of Ganoderma polysaccharides on the activity of DNA polymerase alpha of splenocytes and immune function in aged mice. " Yao Xue Xue Bao, 1993, 28, 577-582.
144. P. G. Xiao; S. T. Xing; L. W. Wang, "Immunological aspects of Chinese medicinal plants as antiageing drugs. " J. Ethnopharmacol., 1993, 38, 167-175.
145. M. Haak-Frendscho; K. Kino; T. Sone; P. Jardieu, "Ling zhi-8: a novel T cell mitogen induces cytokine production and upregulation of ICAM-1 expression. " Cell. Immunol., 1993, 150, 101-113.【C.A. 101: 216956（1993）】
146. A. B. Singh; S. K. Gupta; B. M. Pereira; D. Prakash, "Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. " Clin. Exp. Allergy, 1995, 25, 440-447.
147. W. C. Chen; D. M. Hau; C. C. Wang; I. H. Lin; S. S. Lee, "Effects of Ganoderma lucidum and krestin on subset T-cell in spleen of -irradiated mice. " Am. J. Chin. Med., 1995, 23, 289-298.
148. W. C. Chen; D. M. Hau; S. S. Lee, "Effects of Ganoderma lucidum and krestin on cellular immunocompetence in -ray-irradiated mice. " Am. J. Chin. Med., 1995, 23, 71-80.
149. L. G. van der Hem; J. A. van der Vliet; K. Kino; A. J. Hoitsma; W. J. Tax, "Ling-zhi-8: a fungal protein with immunomodulatory effects. " Transplant. Proc., 1996, 28, 958-959.【C.A. 125: 25831（1996）】
150. S. P. Wasser; A. L. Weis, "Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. " Crit. Rev. Immunol., 1999, 19, 65-96.
151. S. K. Gupta; B. M. Pereira; A. B. Singh, "Ganoderma lucidum: partial characterization of spore and whole body antigenic extracts. " J. Investig. Allergol. Clin. Immunol., 2000, 10, 83-89.
152. M. C. Li; D. S. Liang; Z. M. Xu; L. S. Lei; S. Q. Yang, "Effect of Ganoderma polysaccharides on cAMP in murine peritoneal macrophages. " Zhongguo Zhong Yao Za Zhi, 2000, 25, 41-43.
153. B. S. Min; J. J. Gao; M. Hattori; H. K. Lee; Y. H. Kim, "Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. " Planta Med., 2001, 67, 811-814. 【C.A. 136: 24407（2001）】
154. N. S. Lai; R. H. Lin; R. S. Lai; U. C. Kun; S. C. Leu, "Prevention of autoantibody formation and prolonged survival in New Zealand Black/New Zealand White F1 mice with an ancient Chinese herb, Ganoderma tsugae. " Lupus, 2001, 10, 461-465.
155. J. Zhang; Q. Tang; M. Zimmerman-Kordmann; W. Reutter; H. Fan, "Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum. " Life Sci., 2002, 71, 623-638.
156. J. Luo; Y. Y. Zhao; Z. B. Li, "A new lanostane-type triterpene from the fruiting bodies of Ganoderma lucidum. " J. Asian. Nat. Prod. Res., 2002, 4, 129-134.
157. L. Z. Cao; Z. B. Lin, "Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides. " Immunol. Lett., 2002, 83, 163-169.
158. X. F. Bao; Y. Zhen; L. Ruan; J. N. Fang, "Purification, characterization, and modification of T lymphocyte-stimulating polysaccharide from spores of Ganoderma lucidum. " Chem. Pharm. Bull., 2002, 50, 623-629.
159. X. F. Bao; X. S. Wang; Q. Dong; J. N. Fang; X. Y. Li, "Structural features of immunologically active polysaccharides from Ganoderma lucidum. " Phytochemistry, 2002, 59, 175-181.
160. M. J. Hsu; S. S. Lee; S. T. Lee; W. W. Lin, "Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidum. " Br. J. Pharmacol., 2003, 139, 289-298.
161. Y. Gao; S. Zhou; W. Jiang; M. Huang; X. Dai, "Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. " Immunol. Invest., 2003, 32, 201-215.
162. L. Z. Cao; Z. B. Lin, "Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro. " Acta. Pharmacol. Sin., 2003, 24, 321-326.
163. Q. J. Tang; J. S. Zhang; Y. J. Pan; W. Reutter; H. Fan, "Activation of mouse macrophages by the alkali-extracted polysaccharide from spore of Ganoderma lucidum. " Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2004, 20, 142-144.
164. H. S. Chen; Y. F. Tsai; S. Lin; C. C. Lin; K. H. Khoo; C. H. Lin; C. H. Wong, "Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. " Bioorg. Med. Chem., 2004, 12, 5595-5601.
165. C. M. Chien; J. L. Cheng; W. T. Chang; M. H. Tien; C. M. Tsao; Y. H. Chang; H. Y. Chang; J. F. Hsieh; C. H. Wong; S. T. Chen, "Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood. " Bioorg. Med. Chem., 2004, 12, 5603-5609.
166. H. Y. Hsu; K. F. Hua; C. C. Lin; C. H. Lin; J. Hsu; C. H. Wong, "Extract of reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways. " J. Immunol., 2004, 173, 5989-5999.
167. M. Kohguchi; T. Kunikata; H. Watanabe; N. Kudo; T. Shibuya; T. Ishihara; K. Iwaki; M. Ikeda; S. Fukuda; M. Kurimoto, "Immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi). " Biosci. Biotechnol. Biochem., 2004, 68, 881-887.
168. S. W. Lai; J. H. Lin; S. S. Lai; Y. L. Wu, "Influence of Ganoderma lucidum on blood biochemistry and immunocompetence in horses. " Am. J. Chin. Med., 2004, 32, 931-940.【C.A. 142: 273654（2004）】
169. Z. B. Lin; H. N. Zhang, "Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. " Acta. Pharmacol. Sin., 2004, 25, 1387-1395.
170. B. M. Shao; H. Dai; W. Xu; Z. B. Lin; X. M. Gao, "Immune receptors for polysaccharides from Ganoderma lucidum. " Biochem. Biophys. Res. Commun., 2004, 323, 133-141.
171. X. L. Zhu; Z. B. Lin, "Effects of Ganoderma lucidum polysaccharides on proliferation and cytotoxicity of cytokine-induced killer cells. " Acta. Pharmacol. Sin., 2005, 26, 1130-1137.
172. P. Y. Wang; S. Z. Wang; S. Q. Lin; Z. B. Lin, "Comparison of the immunomodulatory effects of spore polysaccharides and broken spore polysaccharides isolated from Ganoderma lucidum on murine splenic lymphocytes and peritoneal macrophages in vitro. " Beijing Da Xue Xue Bao, 2005, 37, 569-574.
173. R. W. Pero; A. Amiri; Y. Sheng; M. Welther; M. Rich, "Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. " Phytomedicine, 2005, 12, 255-263.
174. Z. B. Lin, "Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum. " J. Pharmacol. Sci., 2005, 99, 144-153.
175. Y. L. Lin; Y. C. Liang; S. S. Lee; B. L. Chiang, "Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-B and p38 mitogen-activated protein kinase pathways. " J. Leukoc. Biol., 2005, 78, 533-543.【C.A. 143: 171288（2005）】
176. Y. Xi Bao; C. Kwok Wong; E. Kwok Ming Li; L. Shan Tam; P. Chung Leung; Y. Bing Yin; C. Wai Kei Lam, "Immunomodulatory effects of lingzhi and san-miao-san supplementation on patients with rheumatoid arthritis. " Immunopharmacol. Immunotoxicol., 2006, 28, 197-200.
177. Y. L. Lin; S. S. Lee; S. M. Hou; B. L. Chiang, "Polysaccharide purified from Ganoderma lucidum induces gene expression changes in human dendritic cells and promotes T helper 1 immune response in BALB/c mice. " Mol. Pharmacol., 2006, 70, 637-644.
178. K. I. Lin; Y. Y. Kao; H. K. Kuo; W. B. Yang; A. Chou; H. H. Lin; A. L. Yu; C. H. Wong, "Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1. " J. Biol. Chem., 2006, 281, 24111-24123.
179. J. Y. Lin; M. L. Chen; B. F. Lin, "Ganoderma tsugae in vivo modulates Th1/Th2 and macrophage responses in an allergic murine model. " Food Chem. Toxicol., 2006, 44, 2025-2032.
180. J. Y. Lin; M. L. Chen; B. L. Chiang; B. F. Lin, "Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model. " Int. Immunopharmacol., 2006, 6, 241-251.
181. T. R. Jinn; C. M. Wu; W. C. Tu; J. L. Ko; J. T. Tzen, "Functional expression of FIP-gts, a fungal immunomodulatory protein from Ganoderma tsugae in Sf21 insect cells. " Biosci. Biotechnol. Biochem., 2006, 70, 2627-2634. 【C.A. 146: 250356（2006）】
182. Y. Yin; W. Fu; M. Fu; G. He; L. Traore, "The immune effects of edible fungus polysaccharides compounds in mice. " Asia. Pac. J. Clin. Nutr., 2007, 16 Suppl, 258-260.
183. X. L. Zhu; A. F. Chen; Z. B. Lin, "Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice. " J. Ethnopharmacol., 2007, 111, 219-226.
184. K. F. Hua; H. Y. Hsu; L. K. Chao; S. T. Chen; W. B. Yang; J. Hsu; C. H. Wong, "Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression. " J. Cell Physiol., 2007, 212, 537-550.
185. W. Cheuk; J. K. Chan; G. Nuovo; M. K. Chan; M. Fok, "Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi) " Int. J. Surg. Patho.l, 2007, 15, 180-186.
186. M. L. Chen; B. F. Lin, "Effects of triterpenoid-rich extracts of Ganoderma tsugae on airway hyperreactivity and Th2 responses in vivo. " Int. Arch. Allergy Immunol., 2007, 143, 21-30.
187. S. Y. Lee; H. M. Rhee, "Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. " Chem. Pharm. Bull., 1990, 38, 1359-1364.
188. Y. Hijikata; S. Yamada, "Effect of Ganoderma lucidum on postherpetic neuralgia. " Am. J. Chin. Med., 1998, 26, 375-381.
189. W. M. Cheung; W. S. Hui; P. W. Chu; S. W. Chiu; N. Y. Ip, "Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. " FEBS Lett., 2000, 486, 291-296. 【C.A. 119: 155775（2000）】
190. H. B. Zhao; S. Q. Lin; J. H. Liu; Z. B. Lin, "Polysaccharide extract isolated from Ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury. " J. Pharmacol. Sci., 2004, 95, 294-298.
191. W. Tang; Y. Gao; G. Chen; H. Gao; X. Dai; J. Ye; E. Chan; M. Huang; S. Zhou, "A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. " J. Med. Food., 2005, 8, 53-58.
192. H. B. Zhao; S. Z. Wang; Q. H. He; L. Yuan; A. F. Chen; Z. B. Lin, "Ganoderma total sterol (GS) and GS1 protect rat cerebral cortical neurons from hypoxia/reoxygenation injury. " Life Sci., 2005, 76, 1027-1037.
193. W. W. Zhu; Z. L. Liu; H. W. Xu; W. Z. Chu; Q. Y. Ye; A. M. Xie; L. Chen; J. R. Li, "Effect of the oil from Ganoderma lucidum spores on pathological changes in the substantia nigra and behaviors of MPTP-treated mice. " Di Yi Jun Yi Da Xue Xue Bao, 2005, 25, 667-671.
194. W. Zhang; Y. S. Zeng; Y. Wang; W. Liu; J. J. Cheng; S. J. Chen, "Primary study on proteomics about Ganoderma lucidum spores promoting survival and axon regeneration of injured spinal motor neurons in rats. " Zhong Xi Yi Jie He Xue Bao, 2006, 4, 298-302.
195. W. Zhang; Y. S. Zeng; Y. Xiong; S. J. Chen; Z. Q. Zhong, "Pre-administration of Ganoderma lucidum spore reduces incidence of neural tube defects induced by retinoic acid in pregnant mice. " Zhong Xi Yi Jie He Xue Bao, 2006, 4, 368-373.
196. J. J. Yang; D. Q. Yu, "Synthesis of Ganoderma alkaloid A and B. " Yao Xue Xue Bao, 1990, 25, 555-559.
197. F. Wan; D. Huang, "Anti-inflammatory and analgesic actions of artificial and fermentative Ganoderma sinense (AFGS). " Zhongguo Zhong Yao Za Zhi, 1992, 17, 619-622, 640.
198. J. M. Lin; C. C. Lin; H. F. Chiu; J. J. Yang; S. G. Lee, "Evaluation of the anti-inflammatory and liver-protective effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats. " Am. J. Chin. Med., 1993, 21, 59-69.
199. J. Patocka, "Anti-inflammatory triterpenoids from mysterious mushroom Ganoderma lucidum and their potential possibility in modern medicine. " Acta Medica, 1999, 42, 123-125.
200. K. J. Hong; D. M. Dunn; C. L. Shen; B. C. Pence, "Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells. " Phytother. Res., 2004, 18, 768-770. 【C.A. 142: 273565（2004）】
201. Y. W. Ho; J. S. Yeung; P. K. Chiu; W. M. Tang; Z. B. Lin; R. Y. Man; C. S. Lau, "Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast. " Mol. Cell. Biochem., 2007.
202. S. Y. Yoon; S. K. Eo; Y. S. Kim; C. K. Lee; S. S. Han, "Antimicrobial activity of Ganoderma lucidum extract alone and in combination with some antibiotics. " Arch. Pharm. Res., 1994, 17, 438-442.
203. B. S. Min; N. Nakamura; H. Miyashiro; K. W. Bae; M. Hattori, "Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. " Chem. Pharm. Bull., 1998, 46, 1607-1612.
204. S. el-Mekkawy; M. R. Meselhy; N. Nakamura; Y. Tezuka; M. Hattori; N. Kakiuchi; K. Shimotohno; T. Kawahata; T. Otake, "Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. " Phytochemistry, 1998, 49, 1651-1657.
205. S. K. Eo; Y. S. Kim; C. K. Lee; S. S. Han, "Antiviral activities of various water and methanol soluble substances isolated from Ganoderma lucidum. " J. Ethnopharmacol., 1999, 68, 129-136.
206. S. K. Eo; Y. S. Kim; C. K. Lee; S. S. Han, "Antiherpetic activities of various protein bound polysaccharides isolated from Ganoderma lucidum. " J. Ethnopharmacol., 1999, 68, 175-181.
207. K. W. Oh; C. K. Lee; Y. S. Kim; S. K. Eo; S. S. Han, "Antiherpetic activities of acidic protein bound polysacchride isolated from Ganoderma lucidum alone and in combinations with acyclovir and vidarabine. " J. Ethnopharmacol., 2000, 72, 221-227.
208. R. A. Mothana; R. Jansen; W. D. Julich; U. Lindequist, "Ganomycins A and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi. " J. Nat. Prod., 2000, 63, 416-418.
209. Y. S. Kim; S. K. Eo; K. W. Oh; C. Lee; S. S. Han, "Antiherpetic activities of acidic protein bound polysacchride isolated from Ganoderma lucidum alone and in combinations with interferons. " J. Ethnopharmacol., 2000, 72, 451-458.
210. S. K. Eo; Y. S. Kim; C. K. Lee; S. S. Han, "Possible mode of antiviral activity of acidic protein bound polysaccharide isolated from Ganoderma lucidum on herpes simplex viruses. " J. Ethnopharmacol., 2000, 72, 475-481.
211. E. F. Smania; F. Delle Monache; A. Smania, Jr.; R. A. Yunes; R. S. Cuneo, "Antifungal activity of sterols and triterpenes isolated from Ganoderma annulare. " Fitoterapia, 2003, 74, 375-377.
212. R. A. Mothana; N. A. Awadh Ali; R. Jansen; U. Wegner; R. Mentel; U. Lindequist, "Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi. " Fitoterapia, 2003, 74, 177-180.
213. K. Iwatsuki; T. Akihisa; H. Tokuda; M. Ukiya; M. Oshikubo; Y. Kimura; T. Asano; A. Nomura; H. Nishino, "Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation. " J. Nat. Prod., 2003, 66, 1582-1585.
214. T. H. Niedermeyer; U. Lindequist; R. Mentel; D. Gordes; E. Schmidt; K. Thurow; M. Lalk, "Antiviral terpenoid constituents of Ganoderma pfeifferi. " J. Nat. Prod., 2005, 68, 1728-1731.
215. Z. Li; J. Liu; Y. Zhao, "Possible mechanism underlying the antiherpetic activity of a proteoglycan isolated from the mycelia of Ganoderma lucidum in vitro. " J. Biochem. Mol. Biol., 2005, 38, 34-40.
216. Y. Hijikata; A. Yasuhara; Y. Sahashi, "Effect of an herbal formula containing Ganoderma lucidum on reduction of herpes zoster pain: a pilot clinical trial. " Am. J. Chin. Med., 2005, 33, 517-523.
217. S. S. Cheng; H. Y. Lin; S. T. Chang, "Chemical composition and antifungal activity of essential oils from different tissues of Japanese Cedar (Cryptomeria japonica). " J. Agric. Food Chem., 2005, 53, 614-619.
218. M. Al-Fatimi; M. Wurster; H. Kreisel; U. Lindequist, "Antimicrobial, cytotoxic and antioxidant activity of selected basidiomycetes from Yemen. " Pharmazie, 2005, 60, 776-780.
219. H. X. Wang; T. B. Ng, "A laccase from the medicinal mushroom Ganoderma lucidum. " Appl. Microbiol. Biotechnol., 2006, 72, 508-513.
220. H. Wang; T. B. Ng, "Ganodermin, an antifungal protein from fruiting bodies of the medicinal mushroom Ganoderma lucidum. " Peptides, 2006, 27, 27-30.
221. A. Smania Jr.; E. F. Smania; F. Della Monache; M. G. Pizzolatti; G. Delle Monache, "Derivatization does not influence antimicrobial and antifungal activities of applanoxidic acids and sterols from Ganoderma spp. " Z. Naturforsch. [C]. 2006, 61, 31-34.
222. M. F. Moradali; H. Mostafavi; G. A. Hejaroude; A. S. Tehrani; M. Abbasi; S. Ghods, "Investigation of potential antibacterial properties of methanol extracts from fungus Ganoderma applanatum. " Chemotherapy, 2006, 52, 241-244.
223. C. H. Su; C. S. Sun; S. W. Juan; C. H. Hu; W. T. Ke; M. T. Sheu, "Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes. " Biomaterials, 1997, 18, 1169-1174.
224. C. H. Su; C. S. Sun; S. W. Juan; H. O. Ho; C. H. Hu; M. T. Sheu, "Development of fungal mycelia as skin substitutes: effects on wound healing and fibroblast. " Biomaterials, 1999, 20, 61-68.
225. W. S. Hung; C. L. Fang; C. H. Su; W. F. Lai; Y. C. Chang; Y. H. Tsai, "Cytotoxicity and immunogenicity of sacchachitin and its mechanism of action on skin wound healing. " J. Biomed. Mater. Res., 2001, 56, 93-100.
226. C. H. Su; S. H. Liu; S. Y. Yu; Y. L. Hsieh; H. O. Ho; C. H. Hu; M. T. Sheu, "Development of fungal mycelia as a skin substitute: characterization of keratinocyte proliferation and matrix metalloproteinase expression during improvement in the wound-healing process. " J. Biomed. Mater. Res. A, 2005, 72, 220-227.
227. M. Kandefer-Szerszen; Z. Kawecki; M. Guz, "Fungal nucleic acids as interferon inducers. " Acta Microbiol. Pol., 1979, 28, 277-291.
228. R. L. Khva; A. V. Vasil'ev; A. N. Orekhov; V. V. Tertov; V. A. Tutel'ian, "Anti-atherosclerotic properties of higher mushrooms (a clinico-experimental investigation). " Vopr. Pitan., 1989, 16-19.
229. Y. Komoda; M. Shimizu; Y. Sonoda; Y. Sato, "Ganoderic acid and its derivatives as cholesterol synthesis inhibitors. " Chem. Pharm. Bull. 1989, 37, 531-533.
230. H. Y. Hsu; S. L. Lian; C. C. Lin, "Radioprotective effect of Ganoderma lucidum (Leyss. ex. Fr.) Karst after X-ray irradiation in mice. " Am. J. Chin. Med., 1990, 18, 61-69.
231. Z. Wen; J. Li; S. He; S. Xiong; X. He, "Effect of Ganoderma japonicum (Fr.) Lloyd mixture on experimental thrombosis. " Hunan Yi Ke Da Xue Xue Bao, 1997, 22, 15-18.
232. K. Koyama; T. Imaizumi; M. Akiba; K. Kinoshita; K. Takahashi; A. Suzuki; S. Yano; S. Horie; K. Watanabe; Y. Naoi, "Antinociceptive components of Ganoderma lucidum. " Planta Med., 1997, 63, 224-227.【C.A. 127: 399798（1997）】
233. A. Berger; D. Rein; E. Kratky; I. Monnard; H. Hajjaj; I. Meirim; C. Piguet-Welsch; J. Hauser; K. Mace; P. Niederberger, "Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. " Lipids Health Dis., 2004, 3, 2.
234. N. Futrakul; T. Panichakul; P. Butthep; P. Futrakul; P. Jetanalin; S. Patumraj; P. Siriviriyakul, "Ganoderma lucidum suppresses endothelial cell cytotoxicity and proteinuria in persistent proteinuric focal segmental glomerulosclerosis (FSGS) nephrosis. " Clin. Hemorheol. Microcirc., 2004, 31, 267-272.
235. Y. Gao; W. Tang; H. Gao; E. Chan; J. Lan; S. Zhou, "Ganoderma lucidum polysaccharide fractions accelerate healing of acetic acid-induced ulcers in rats. " J. Med. Food., 2004, 7, 417-421.
236. W. S. Hung; W. F. Lai; B. Leu; C. H. Su; C. L. Fang; Y. H. Tsai, "Effect of sacchachitin on keratinocyte proliferation and the expressions of type I collagen and tissue-transglutaminase during skin wound healing. " J. Biomed. Mater. Res. B Appl. Biomater., 2004, 70, 122-129.
237. W. Q. Chen; S. H. Luo; H. Z. Ll; H. Yang, "Effects of Ganoderma lucidum polysaccharides on serum lipids and lipoperoxidation in experimental hyperlipidemic rats. " Zhongguo Zhong Yao Za Zhi, 2005, 30, 1358-1360.
238. M. Yang; H. Sun; D. W. Yu; Z. Y. Cui; J. Tian, "Effects of the polysaccharides isolated from Ganoderma applanatum (PGA) on the level of PGE2 and gastric mucosal blood flow (GMBF) and gastric mucus secretion of rats with gastric mucosa injury. " Zhongguo Zhong Yao Za Zhi, 2005, 30, 1176-1178.
239. Y. Kwok; K. F. Ng; C. C. Li; C. C. Lam; R. Y. Man, "A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. " Anesth. Analg., 2005, 101, 423-426, table of contents.
240. N. Kubo; Y. Myojin; F. Shimamoto; N. Kashimoto; E. Kyo; K. Kamiya; H. Watanabe, "Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei Murill. against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death. " Int. J. Mol. Med., 2005, 15, 401-406.
241. B. X. Wang; S. Q. Wang; W. B. Qin; S. X. Wang; X. R. Ma; T. Zhang, "Effects of Ganoderma lucidum spores on cytochrome C and mitochondrial calcium in the testis of NIDDM rats. " Zhonghua Nan Ke Xue, 2006, 12, 1072-1075.
242. C. Li; Y. Li; H. H. Sun, "New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum. " Nat. Prod. Res., 2006, 20, 985-991.
243. S. H. Lee; S. H. Shim; J. S. Kim; S. S. Kang, "Constituents from the fruiting bodies of Ganoderma applanatum and their aldose reductase inhibitory activity. " Arch. Pharm. Res., 2006, 29, 479-483.
244. Q. P. Chu; L. E. Wang; X. Y. Cui; H. Z. Fu; Z. B. Lin; S. Q. Lin; Y. H. Zhang, "Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. " Pharmacol. Biochem. Behav., 2007, 86, 693-698.
245. J. Ma; Q. Ye; Y. Hua; D. Zhang; R. Cooper; N. Chang Michael; Y. Chang Joseph; H. Sun Hao, "New lanostanoids from the mushroom Ganoderma lucidum. " J. Nat. Prod., 2002, 65, 72-75.
246. M. S. Shiao; L. J. Lin; S. F. Yeh, "Triterpenes from Ganoderma lucidum. " Phytochemistry, 1988, 27, 2911-2914.【C.A. 109: 208287（1988）】
247. J. Rosecke; W. A. Konig, "Constituents of various wood-rotting basidiomycetes. " Phytochemistry, 2000, 54, 603-610.
248. K.-H. Gan; S.-H. Kuo; C.-N. Lin, "Steroidal constituents of Ganoderma applanatum and Ganoderma neo-japonicum. " J. Nat. Prod., 1998, 61, 1421-1422.
249. D. Kac; G. Barbieri; M. R. Falco; A. M. Seldes; E. G. Gros, "The major sterols from three species of Polyporaceae. " Phytochemistry, 1984, 23, 2686-2687.【C.A. 101: 226980（1984）】
250. C. N. Lin; S. H. Kuo; S. J. Won, "Steroids of Formosan Ganoderma amboinense. " Phytochemistry, 1993, 32, 1549-1551.
251. Chairul; T. Tokuyama; Y. Hayashi; M. Nishizawa; H. Tokuda; S. M. Chairul; Y. Hayashi, "Applanoxidic acids A, B, C and D, biologically active tetracyclic triterpenes from Ganoderma applanatum. " Phytochemistry, 1991, 30, 4105-4109.
252. Chairul; S. M. Chairul; Y. Hayashi, "Lanostanoid triterpenes from Ganoderma applanatum. " Phytochemistry, 1994, 35, 1305-1308.
253. F. Leon; M. Valencia; A. Rivera; I. Nieto; J. Quintana; F. Estevez; J. Bermejo, "Novel cytostatic lanostanoid triterpenes from Ganoderma australe. " Helv. Chim. Acta, 2003, 86, 3088-3095.
254. L. I. Strigina; Y. N. Elkin; G. B. Elkyakov, "Steroid metabolites of Ganoderma applanatum basidiomycete. " Phytochemistry, 1971, 10, 2361-2365. 【C.A. 76: 1641（1971）】
255. S. H. Shim; J. Ryu; J. S. Kim; S. S. Kang; Y. Xu; S. H. Jung; Y. S. Lee; S. Lee; K. H. Shin, "New lanostane-type triterpenoids from Ganoderma applanatum. " J. Nat. Prod., 2004, 67, 1110-1113.
256. Y. Komoda; H. Nakamura; S. Ishihara; M. Uchida; H. Kohda; K. Yamasaki, "Structures of new terpenoid constituents of Ganoderma lucidum (Fr.) Karst (Polyporaceae). " Chem. Pharm. Bull., 1985, 33, 4829-4835.
257. D. Ming; J. Chilton; F. Fogarty; G. H. N. Towers, "Chemical constituents of Ganoderma applanatum of British Columbia forests. " Fitoterapia, 2002, 73, 147-152.
258. T. Nishitoba; S. Goto; H. Sato; S. Sakamura, "Bitter triterpenoids from the fungus Ganoderma applanatum. " Phytochemistry, 1989, 28, 193-197.
259. L. J. Lin; M. S. Shiao; S. F. Yeh, "Triterpenes from Ganoderma lucidum. " Phytochemistry, 1988, 27, 2269-2271.【C.A. 109: 187268（1988）】
260. T. Kikuchi; S. Kanomi; S. Kadota; Y. Murai; K. Tsubono; Z. Ogita, "Constituents of the fungus Ganoderma lucidum (Fr.) Karst. I. Structures of ganoderic acids C2, E, I, and K, lucidenic acid F and related compounds. " Chem. Pharm. Bull., 1986, 34, 3695-3712.
261. M. Hirotani; T. Furuya; M. Shiro, "Studies on the metabolites of higher fungi. Part 4. A ganoderic acid derivative, a highly oxygenated lanostane-type triterpenoid from Ganoderma lucidum. " Phytochemistry, 1985, 24, 2055-2061.
262. J. Protiva; H. Skorkovska; J. Urban; A. Vystrcil, "Triterpenes. LXIII. Triterpenes and steroids from Ganoderma applanatum. " Collect. Czech. Chem. Commun., 1980, 45, 2710-2713.
263. A. Morigiwa; K. Kitabatake; Y. Fujimoto; N. Ikekawa, "Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidum. " Chem. Pharm. Bull., 1986, 34, 3025-3028.
264. C. N. Lin; W. P. Tome; S. J. Won, "A lanostanoid of Formosan Ganoderma lucidum. " Phytochemistry, 1990, 29, 673-675.
265. A. C. Jain; S. K. Gupta, "The isolation of lanosta-7,9(11),24-trien-3b,21-diol from the fungus Ganoderma australe. " Phytochemistry, 1984, 23, 686-687.
266. H. Ripperger; H. Budzikiewicz, "Steroids from Ganoderma applanatum. " Phytochemistry, 1975, 14, 2297-2298.
267. X. A. Dominguez; D. BuTruille; A. Zamudio; C. Reyes G; J. Castillo T, "Ergosterol and L-mannitol from parasitic fungi. " Phytochemistry, 1972, 11, 2616-2617.
268. S. Lee; H. Shim Sang; S. Kim Ju; H. Shin Kuk; S. Kang Sam, "Aldose reductase inhibitors from the fruiting bodies of Ganoderma applanatum. " Biol. Pharm. Bull., 2005, 28, 1103-1105. 【C.A. 143: 260264（2005）】
269. L. Lukacs; J. Zellner, "Chemistry of the higher fungi. XXII. Ganoderma lucidum Leiss, Hydnum imbricatum L. and Cantharellus clavatus Pers. " Monatshefte fuer. Chemie., 1933, 62, 214-219. 【C.A. 27: 50966（1933）】
270. S. F. Hussain; G. A. Miana; S. Rahman, "Mannitol from Fomes fomentarius and Ganoderma lucidum. " Pakistan J. Sci. Indust. Res., 1971, 14, 58. 【C.A. 75: 106383（1971）】
271. T. Kubota; Y. Asaka; I. Miura; H. Mori, "Structures of ganoderic acid A and B, two new lanostane type bitter triterpenes from Ganoderma lucidum (Fr.) Karst. " Helv. Chim. Acta, 1982, 65, 611-619.【C.A. 96: 214298（1982）】
272. A. C. Keller; J. Keller; M. P. Maillard; K. Hostettmann, "A lanostane-type steroid from the fungus Ganoderma carnosum. " Phytochemistry, 1997, 46, 963-965.
273. P. Kleinwachter; N. Anh; T. T. Kiet; B. Schlegel; H. M. Dahse; A. Hartl; U. Grafe, "Colossolactones, new triterpenoid metabolites from a Vietnamese mushroom Ganoderma colossum. " J. Nat. Prod., 2001, 64, 236-239.
274. J. O. Toth; B. Luu; G. Ourisson, "Ganoderic acid T and Z: cytotoxic triterpenes from Ganoderma lucidum (Polyporaceae). " Tetrahedron Lett., 1983, 24, 1081-1084.
275. T. Kikuchi; S. Kanomi; Y. Murai; S. Kadota; K. Tsubono; Z. Ogita, "Constituents of the fungus Ganoderma lucidum (Fr.) Karst. II. Structures of ganoderic acids F, G, and H, lucidenic acids D2 and E2, and related compounds. " Chem. Pharm. Bull., 1986, 34, 4018-4029.
276. S. El-Mekkawy; M. R. Meselhy; N. Nakamura; Y. Tezuka; M. Hattori; N. Kakiuchi; K. Shimotohno; T. Kawahata; T. Otake, "Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. " Phytochemistry, 1998, 49, 1651-1657.
277. M. Hirotani; C. Ino; T. Furuya; M. Shiro, "Studies on the metabolites of higher fungi. Part 6. Ganoderic acids T, S and R, new triterpenoids from the cultured mycelia of Ganoderma lucidum. " Chem. Pharm. Bull., 1986, 34, 2282-2285.
278. Chairul; T. Tokuyama; M. Nishizawa; M. Shiro; H. Tokuda; Y. Hayashi, "Malonate half-esters of homolanostanoid from an Asian Ganoderma fungus. " Phytochemistry, 1990, 29, 923-928.
279. M. Hirotani; T. Furuya; M. Shiro, "Studies on the metabolites of higher fungi. Part 10. Cryptoporic acids H and I, drimane sesquiterpenes from Ganoderma neo-japonicum and Cryptoporus volvatus. " Phytochemistry, 1991, 30, 1555-1559.
280. M. Hirotani; C. Ino; A. Hatano; H. Takayanagi; T. Furuya, "Ganomastenols A, B, C and D, cadinene sesquiterpenes, from Ganoderma mastoporum. " Phytochemistry, 1995, 40, 161-165.
281. H. Kohda; W. Tokumoto; K. Sakamoto; M. Fujii; Y. Hirai; K. Yamasaki; Y. Komoda; H. Nakamura; S. Ishihara; M. Uchida, "The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes. " Chem. Pharm. Bull., 1985, 33, 1367-1374.
282. T. Nishitoba; H. Sato; T. Kasai; H. Kawagishi; S. Sakamura, "New bitter C27 and C30 terpenoids from the fungus Ganoderma lucidum (Reishi). " Agric. Biol. Chem., 1985, 49, 1793-1798.
283. T. Nishitoba; H. Sato; S. Sakamura, "New terpenoids, ganoderic acid J and ganolucidic acid C, from the fungus Ganoderma lucidum. " Agric. Biol. Chem., 1985, 49, 3637-3638.
284. T. Nishitoba; H. Sato; S. Sakamura, "New terpenoids, ganolucidic acid D, ganoderic acid L, lucidone C and lucidenic acid G, from the fungus Ganoderma lucidum. " Agric. Biol. Chem., 1986, 50, 809-811.
285. T. Nishitoba; K. Oda; H. Sato; S. Sakamura, "Novel triterpenoids from the fungus Ganoderma lucidum. " Agric. Biol. Chem., 1988, 52, 367-372.
286. J. O. Toth; B. Luu; J. P. Beck; G. Ourisson, "Ganoderma lucidum. " J. Chem. Res. Miniprint, 1983, 12, 2722-2787.
287. M. Hirotani; C. Ino; T. Furuya, "Studies on the metabolites of higher fungi. Part 12. Comparative study on the strain-specific triterpenoid components of Ganoderma lucidum. " Phytochemistry, 1993, 33, 379-382.
288. T. Nishitoba; H. Sato; S. Sakamura, "Novel mycelial components, ganoderic acid Mg, Mh, Mi, Mj and Mk, from the fungus Ganoderma lucidum. " Agric. Biol. Chem., 1987, 51, 1149-1153.
289. T. Nishitoba; H. Sato; S. Shirasu; S. Sakamura, "Novel triterpenoids from the mycelial mat at the previous stage of fruiting of Ganoderma lucidum. " Agric. Biol. Chem., 1987, 51, 619-622.
290. M. Hirotani; I. Asaka; C. Ino; T. Furuya; M. Shiro, "Studies on the metabolites of higher fungi. Part 7. Ganoderic acid derivatives and ergosta-4,7,22-triene-3,6-dione from Ganoderma lucidum. " Phytochemistry, 1987, 26, 2797-2803.
291. M. S. Shaio; L. J. Lin; S. F. Yeh, "Triterpenes in Ganoderma lucidum. " Phytochemistry, 1988, 27, 873-875.
292. L. J. Lin; K. R. Lee; M. S. Shiao, "Partition coefficients in octanol-water and liquid chromatographic behavior of eight oxygenated triterpenes which are paired stereo- and positional isomers. " J.Chin.Chem.Soc., 1995, 42, 981-986.
293. T. Nishitoba; H. Sato; S. Sakamura, "Triterpenoids from the fungus Ganoderma lucidum. " Phytochemistry, 1987, 26, 1777-1784.
294. T. Kikuchi; S. Matsuda; S. Kadota; Y. Murai; Z. Ogita, "Ganoderic acid D, E, F, and H and lucidenic acid D, E, and F, new triterpenoids from Ganoderma lucidum. " Chem. Pharm. Bull., 1985, 33, 2624-2627.
295. M. Hirotani; T. Furuya, "Studies on the metabolites of higher fungi. Part 5. Ganoderic acid derivatives, highly oxygenated lanostane-type triterpenoids, from Ganoderma lucidum. " Phytochemistry, 1986, 25, 1189-1193.
296. T. Kikuchi; S. Matsuda; Y. Murai; Z. Ogita, "Ganoderic acid G and I and ganolucidic acid A and B, new triterpenoids from Ganoderma lucidum. " Chem. Pharm. Bull., 1985, 33, 2628-2631.
297. T. Kikuchi; S. Kanomi; Y. Murai; S. Kadota; K. Tsubono; Z. Ogita, "Constituents of the fungus Ganoderma lucidum (Fr.) Karst. III. Structures of ganolucidic acids A and B, new lanostane-type triterpenoids. " Chem. Pharm. Bull., 1986, 34, 4030-4036.
298. A. G. Gonzalez; F. Leon; A. M. Rivera, Claudia M.; J. Bermejo, "Lanostanoid triterpenes from Ganoderma lucidum "J. Nat. Prod., 1999, 62, 1700 - 1701.
299. H. Sato; T. Nishitoba; S. Shirasu; K. Oda; S. Sakamura, "Ganoderiol A and B, new triterpenoids from the fungus Ganoderma lucidum (Reishi). " Agric. Biol. Chem., 1986, 50, 2887-2890.
300. 陳若雲; 于德泉, "用二維核磁共振技術研究赤芝孢子內酯A和B的結構. " 藥學學報, 1991, 26, 430-436頁.
301. T. Nishitoba; H. Sato; S. Sakamura, "New terpenoids from Ganoderma lucidum and their bitterness. " Agric. Biol. Chem., 1985, 49, 1547-1549.
302. T. S. Wu; L. S. Shi; S. C. Kuo; C. Y. Cherng; S. F. Tung; C. M. Teng, "Platelet aggregation inhibitor from Ganoderma lucidum "J. Chin. Chem. Soc., 1997, 44, 157-162.
303. M. Hirotani; T. Furuya, "Studies on the metabolites of higher fungi. Part 8. Changes of the triterpenoid patterns during formation of the fruit body in Ganoderma lucidum. " Phytochemistry, 1990, 29, 3767-3771.
304. H. Kawagishi; F. Fukuhara; M. Sazuka; A. Kawashima; T. Mitsubori; T. Tomita, "5'-Deoxy-5'-methylsulphinyladenosine, a platelet aggregation inhibitor from Ganoderma lucidum. " Phytochemistry, 1993, 32, 239-241.
305. C. Li; Y. Li; H. H. Sun, "New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum. "c, 2006, 20, 985–991.
306. K. M. Jenkins; P. R. Jensen; W. Fenical, "Thraustochytrosides A-C: new glycosphingolipids form a unique marine protist, Thraustochytrium globosum. " Tetrahedron Lett., 1999, 40, 7637-7640.
307. M. S. Ali; Y. Tezuka; S. Awale; A. H. Banskota; S. Kadota, "Six new diarylheptanoids from the seeds of Alpinia blepharocalyx " J. Nat. Prod., 2001, 64, 289-293.
308. T. Morikawa; S. A. Jing Tao; H. Matsuda; M. Yoshikawa, "Absolute stereostructures of new arborinane-type triterpenoids and inhibitors of nitric oxide production from Rubia yunnanensis. " J. Nat. Prod., 2003, 66, 638-645.
309. Y. H. Kuo; P. H. Lee; Y. S. Wein, "Four new compounds from the seeds of Cassia fistula. " J. Nat. Prod., 2002, 65, 1165-1167.
310. P. W. Hsieh; F. R. Chang; K. H. Lee; T. L. Hwang; S. M. Chang; Y. C. Wu, "A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid,diandraflavone, from Drymaria diandra. " J. Nat. Prod., 2004, 67, 1175-1177.
311. M. M. Abou-Zaida; C. Nozzolillo, "1-O-galloyl--L-rhamnose from Acer rubrum. " Phytochemistry, 1999, 52, 1629-1631.