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研究生： 楊哲皓
Yang, Che-Hao
論文名稱： 利用可見光至紅外光光譜系統量測仿體及皮膚生理參數
Quantification of the optical properties of tissue phantom and skin properties by using a UV to NIR spectrum system
指導教授： 曾盛豪
Tseng, Sheng-Hao
學位類別： 碩士
Master
系所名稱： 理學院 - 光電科學與工程學系
Department of Photonics
論文出版年： 2012
畢業學年度： 100
語文別： 英文
論文頁數： 79
中文關鍵詞： 生醫光學 、吸收 、散射 、光學物質
外文關鍵詞： Biophotonics, Medicalphotonics, Absorption, Scattering, Optical properties
相關次數： 點閱：80  下載：3 
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    • 我們發展了一套光學系統可以對光學物質量化生理參數濃度及其吸收係數，系統利用了可見光的偵測器和不可見光的偵測器拓展波長的偵測範圍從可見光到紅外光波段，我們的系統不只可以量測光學物質的穿透頻譜也可以量測反射頻譜，量測穿透頻譜我們可以得到物質本身最不同頻率光的吸收，量測反射頻譜我們可以利用演算法去量化物質內參數的濃度，我們利用了兩套光傳波理論分別是擴散理論跟快速蒙地卡羅，由我們的結論在不同的吸收與散射的仿體中，我們可以選擇使用不同的光傳波理論去進行運算來達到最佳化的效果。

    We constructed a spectroscopy system to quantify the absorption of scattering properties in the VIS-NIR range by employing an InGaAs detector and a silicon detector. With our system, we were able to acquire transmission and reflectance spectra from pure absorbing and turbid media in the wavelength range 500 and 1300 nm. The biological chromophore concentrations were estimated by fitting a mathematical model derived from diffusion theory and Scaling Monte Carlo. A scaling Monte Carlo method has developed to calculate diffuse reflectance. Our result suggest that diffusion reflectance in different place can change between Diffusion theory and Scaling Monte Carlo.

    Table of contents Abstract I 摘要 II Acknowledgement III Table of contents IV List of Tables VI List of Figures VII Chapter 1 Introduction 1 1-1 Introduction 1 Chapter2 Theoretical Background 4 2-1 Tissue optics 4 2-1-1 Absorption coefficient 4 2-1-2 Scattering coefficient 5 2-2 Beer's law 6 2-2-1Different concentration 7 2-2-2 Different path length 8 2-3 Monte Carlo Modeling of Light Transport in Multi-layered Tissues 9 2-4 Scaling method for fast Monte Carlo simulation 14 2-5 Radiative Transfer Equation and Diffusion Theory 15 2-5-2 The RTE in the Diffusion Approximation 17 2-5-3 The Diffusion Equation 18 Chapter 3 Method and Material 19 3-1 Experimental setup 19 3-2 Detector analysis and pre-processing 21 3-3 Phantom reflectance measuring and calibration 24 3-4 Mathematical modeling of spectra fitting 28 Chapter 4 Results and Discussion 31 4-1 Analysis the linearity of the response of the detectors 31 4-2 Measure absorption of Lipid and Water 33 4-2-1 CCD (silicon detector) 33 4-2-2 InGaAs detector 44 4-2 Verification between Monte Carlo and Scaling Monte Carlo 49 4-3 Compare the Reflectance spectrum between scaling Monte Carlo, Wang’s Monte Carlo and Diffusion theory 53 4-4 The Result between Diffusion theory and Scaling Monte Carlo after spectrum fitting the measured spectrum. 63 Chapter 5 Conclusion and Future work 75 5-1 Conclusion 75 5-2 Future work 75 Reference 77

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