隨著時代進步，人類對於環保意識的需求逐漸提升，從原物料生產及製程的改良，環保已被默默地包裝成商品融入社會之中。故本研究中著重於針對環境友善的原料生產方式出發點，並試圖以更節省資源的製程方式取代原先製程以期能更有實用價值。色譜方法(Chromatography)為分離琥珀酸的其中一種方法，傳統批式色譜方法在分離成分物的過程中經常產生大量的廢水處本並且效率低落；逆流式移動床儘管改善了以上缺點，但仍須面臨設備移動耗損的缺點。模擬移動床(SMB)成為了新興的取代方法，既能保留逆流式色譜法的優點也同時摒棄了其缺點，也是近年來熱門的研究題材。
本研究方法論中闡述了詳細的模擬移動床設計方法，結合動態數學模型、數值分析、分離理論以及最佳化方法以獲得最少的脫附劑消耗量且能應用於規模放大之模擬移動床模型，並使用Aspen Chromatography作為動態模擬計算軟體以驗證模型準確性。
根據選擇性提出不同的串級模擬移動床可能設計情境，由結果顯示先採用Reillex 425吸附樹脂再採用Amberchrom CG300C吸附樹脂之串級模擬移動床設計能獲得純度99.9%琥珀酸、96.8%之乙酸及99.9%之甲酸，回收率則可達97.7%琥珀酸、99.9%之乙酸及99.5%之甲酸。

With the progress of the times, demand for environmental friendliness has gradually increased. From the improvement of raw material production and process, environmental friendliness has been silently packaged into commodities and integrated into society. Therefore, this study focuses on environmentally friendly raw material production methods and attempts to replace the original process with a more resource-saving process. Chromatography is one of the methods for separating succinic acid. Traditional batch chromatography methods often incur large wastewater treatment costs and low efficiency in the process of separating components; the counter-flow moving bed improves the above shortcomings, but still faces the disadvantage of equipment abrasion due to the movement. Simulated moving bed (SMB) has become a more advanced method, which not only retains the advantages of countercurrent chromatography but also discards its disadvantages and is also a popular research topic in recent years.
In this research, a detailed simulated moving bed design method is described, combined with dynamic mathematical model, numerical analysis, separation theory and optimization methods to obtain the least desorbent consumption and can be applied to a simulated moving bed model for scale-up. Aspen Chromatography is used as the simulation software to validate the model accuracy.
According to the adsorptivity and selectivity of different adsorbents to the components, different possible scenarios of the cascade simulated moving bed are proposed. The results show that the cascade simulated moving bed design using Reillex 425 resin and Amberchrom CG300C resin can separate acid with high purity and recovery.

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