在金奈米粒子(Gold nanoparticles,GNPs)的製造中，物理法與化學法是最為常見的方法，本篇利用化學還原合成法合成出尺寸超過一百奈米的奈米金立方體(Gold nanocubes,GNCs)與奈米金棒(Gold nanorods,GNRs)，並期望其在未來有抗血管生長治療的效果。
同時，近年在癌症治療中的新興藥物，葡萄糖氧化酶(Glucose oxidase,GOx) 藉由消耗細胞中葡萄糖產生雙氧水的特性，使其在達到飢餓治療之外，更可以藉由雙氧水和其他藥物產生協同治療，例如：Fenton reaction、Fenton-like reaction中雙氧水和金屬離子反應產生活性氧物質(Reactive oxygen species,ROS)達到化學動力治療 (Chemodynamic Therapy)，又或者與一氧化碳釋放材料(Carbon monoxide releasing materials,CORM)反應產生出的一氧化碳(CO)，來達到CO治療。
除此之外，利用化學合成法中的熱裂解，製造出氧化錳奈米粒子(Manganese Monoxide Nanoparticles,MnO)，並在外層修飾具孔洞的二氧化矽層(SiO2)與GOx ，且在孔洞中裝載五羰基鐵(Fe(CO)5)作為CORM。在癌細胞的酸性環境下，中心的MnO會被酸蝕並釋放出錳離子(Mn2+)，而GOx消耗葡萄糖產生的H2O2與Mn2+和Fe(CO)5反應，達到飢餓治療與化學動力治療的效果。

In the present works, we have used chemical reduction method to make two different shapes of gold nanoparticles, namely gold nanorods (GNRs) and gold nanocubes (GNCs). Moreover, using thermal decomposition method manganese monoxide nanoparticles (MnO) were synthesized. Both gold nanoparticles size were bigger than 100 nm, because of those special size, it might have application on anti-angiogenic therapy. In another part, we designed a nanoformulation combining manganese monoxide, glucose oxidase (GOx) and Fe(CO)5, for synergistic therapeutic effect by combining chemodynamic therpay (CDT), starvation therapy and CO gas therapy. First, GOx would consume glucose from cell not only had starvation therapy but also produced hydrogen peroxide (H2O2) and hydrogen ions (H+). Subsequently the acidic condition would let MnO be etched and release Mn2+. Furthermore, H2O2 would reacted with Mn2+ and Fe(CO)5, thereby leading to chemodynamic therpay and CO gas therapy, respectively.

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