我們實驗室自坊間宣稱具有抗癌療效的豆科植物中，收集到地方品種Canavailia galadiata種子，利用不同的萃取方法，探討其粗萃取液是否具有抗癌活性。再從具有抗癌活性的部分進行純化分離，找出具有抗癌活性的級分(fraction)或指標成分，並探討其活體生物毒性及抗癌活性的機制。初步篩選到一個級分 (fraction)，命名為IC-1。IC-1在一些人類癌細胞株中，具有良好的毒殺作用，細胞週期分析 (cell cycle analysis) 顯示IC-1對於癌細胞株所產生的細胞毒殺作用，可能是藉由細胞凋亡 (apoptosis) 而來的。使用IC-1和一些抗癌藥(例如:Doxorubucin，5-Fu，VP-16) 進行合併療法 (combination therapy)，得知IC-1具有增強化療藥物的作用。在抑制血管新生的活性上，我們發現IC-1確實能影響到內皮細胞BAEC之移行 (cell migration) 的能力。我們也使用雞胚胎卵黃囊試驗法(chicken chorioallantonic membrane，CAM assay)，來觀察IC-1在活體中抑制血管新生的情形，結果發現IC-1能有效的抑制血管新生。癌細胞移行實驗 ( cell migration assay) 證實IC-1能有效抑制PC-3的移行能力。在動物實驗方面，發現將NIH3T3/7-4 cells 以腹腔注射方式打入Balb/c mice 後，在24hr後立即給予IC-1，能有效的延長存活天數。另一模式為小鼠路易士肺癌轉移模式，目的是測試藥物在體內是否具有抑制腫瘤轉移的能力，其結果為IC-1無論對於原位腫瘤或轉移的腫瘤均具有良好的抑制作用。

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