本研究主要分為三部分，第一部份是發展一套簡易快速的乾式量測系統。利用壓克力及假體進行檢測已評估系統的精確度與準確度，結果顯示出非常高的準確度 (97%) 及低的變異係數 (0.25%)。本系統用來對貼附豬皮的假體進行測試之結果發現，豬皮使得SOS增加。

　　第二部份是發展一套能量測骨組織厚度，並能消除軟組織影響的濕式系統。利用上述的雙探頭技術對貼附豬皮的假體進行量測，結果發現，所量測的骨假體厚度準確度很高(正常骨假體98.7％；疏鬆骨假體98.6％)。修正後的SOS準確度高(正常骨假體98.4％；疏鬆骨假體99％)。

　　第三部份為活體測試，五名受測者各接受兩套系統的測試。結果顯示，本濕式系統可以計算出腳跟骨的厚度並且有效的消除軟組織對SOS量測的影響。

　　綜合以上，假體模擬試驗與人體量測實驗的結果皆顯示出軟組織會導致量測到的SOS增加的趨勢，本研究利用濕式系統的原理可以消除軟組織的效應進而計算出骨組織中的波速。

　The works in this study are divided into three parts. The first part was to develop a convenient and quick dry contact system. We estimate the precision and validity from investigations examining acrylic plastic and bone phantoms. High accuracy (97%) and low stand deviation (0.25%) are show on the results. We apply the dry contact system to the simulation of bone phantom covered with porcine skins. Results show that porcine skin increases the SOS values.

　The second part is to develop a water immersed system which can measure the bone thickness and eliminate influence of soft tissue. We apply the dual transducers technique described above to the simulation of bone phantom covers with porcine skins. The accuracy in measuring bone phantom thickness is high (normal bone phantom：98.7%; osteoporotic bone phantom: 98.6%). The accuracy in modified SOS is high (normal bone phantom：98.4% ; osteoporotic bone phantom : 99%).

　The third part was in vivo test. Five volunteers were tested in this study. With the results, the thickness of calcaneus can be obtained and it is possible to eliminate the influence of soft tissue on phantom SOS measurement.

　Furthermore, there are the same trends of SOS variation in phantom simulation and in vivo measurement. It concludes that soft tissue increase SOS values and it is possible to eliminate the effect of soft tissue on human bone SOS by using the proposed water immersed system.

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